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Active Recombinant Mouse Il25 Protein, His-Tagged

Cat.No. : Il25-01M
Product Overview : Recombinant mouse Il25 Protein, His-tagged was expressed in E. coli cell
  • Specification
  • Gene Information
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Description : Interleukin-25 (IL-25) is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. IL-25 is a member of the IL-17 family of cytokines. However, unlike the other members of this family, IL-25 promotes T helper (Th) 2 responses. IL-25 also regulates the development of autoimmune inflammation mediated by IL-17–producing T cells. IL-25 and IL-17, being members of the same cytokine family, play opposing roles in the pathogenesis of organ-specific autoimmunity.
Source : Escherichia coli
Species : Mouse
Tag : His
Form : Lyophilized powder
AA Sequence : MVSLRIQEGCSHLPSCCPSKEQEPP EEWLKWSSASVSPPEPLSHTHHAES CRASKDGPLNSRAISPWSYELDRDL NRVPQDLYHARCLCPHC
VSLQTGSHMDPLGNSVPLYHNQTVF YRRPCHGEEGTHRRYCLERRLYRVS LACVCVRPRVMA with polyhistidine tag at the C-terminus
Endotoxin : <0.1 EU per 1 μg of the protein by the LAL method.
Bio-activity : Measured by its ability to induce CXCL1 secretion in HT‑29 cells. The ED50 for this effect is <1 ng/mL.
Purity : >98% as determined by SDS-PAGE. Ni-NTA chromatography
Storage Buffer : The protein was lyophilized from a solution containing 20 mM sodium citrate, 0.2 M NaCl, pH 4.5.
Reconstitution : It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
Storage : Lyophilized protein should be stored at -20°C. Upon reconstitution, protein aliquots should be stored at -20°C or -80°C.
Notes : Please use within one month after protein reconstitution.
Gene Name : Il25 interleukin 25 [ Mus musculus (house mouse) ]
Official Symbol : Il25
Synonyms : Il17e; IL-17e
Gene ID : 140806
mRNA Refseq : NM_080729.3
Protein Refseq : NP_542767.1
UniProt ID : Q8VHH8

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Is there any research showing that IL-25 is effective in tumor treatment? 12/10/2022

There is a lack of conclusive evidence that IL-25 has a clear effect in tumor treatment, but there are some studies underway.

Are there any side effects to IL-25? 09/22/2021

There are no clear studies on the side effects of IL-25, but the patient response needs to be closely monitored during research and clinical application.

Has the study found potential applications of IL-25 in the treatment of other diseases? 01/18/2021

In addition to treating asthma and inflammatory bowel disease, IL-25 may also have potential applications in the treatment of lung infections, urticaria and other diseases.

What is the mechanism of action of IL-25? 12/18/2020

IL-25 activates specific signaling pathways by binding to specific receptors, thereby regulating the activity of immune cells and the degree of inflammation in the body.

Is there any research showing that IL-25 is effective against certain diseases? 08/17/2020

Some studies have shown that recombinant IL-25 can improve symptoms of diseases such as asthma and inflammatory bowel disease, but more research is needed to verify its efficacy.

Does IL-25 therapy need to be administered by injection? 03/28/2019

Yes, in general, IL-25 therapy needs to be administered by injection to ensure that the protein can enter the body and work.

Customer Reviews (3)

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Reviews
01/29/2021

    The activity is very strong and can meet my research needs.

    08/31/2019

      Price is very reasonable and good value for money.

      01/05/2019

        It is very stable and can be stored and used for a long time.

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