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Recombinant Mouse Interleukin 25, His-tagged

Cat.No. : Il25-748M
Product Overview : A DNA sequence encoding the mature form of mouse Il25 was expressed with a N-terminal polyhistidine tag. The secreted recombinant mouse Il25 consists of 175 amino acids and has a calculated molecular mass of 20 kDa.
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Description : Interleukin 25 (Il25), also known as IL17E, is a cytokine that belongs to the IL17 cytokine family and is secreted by type 2 helper T cells (Th2) and mast cells.Il25 induces the production of other cytokines, including IL-4, IL-5 and IL-13 in multiple tissues, then induces Th2 immune responses such as blood eosinophilia and increased serum immunoglobulin E levels.This cytokine is an important molecule controlling immunity of the gut and has been implicated in chronic inflammation associated with the gastrointestinal tract. Further, the Il25 gene has been identified in a chromosomal region associated with autoimmune diseases of the gut such as inflammatory bowel disease (IBD). In addition, studies shown that enforced expression of Il25 in the lung significantly enhances antigen-induced Th2 cytokine production and eosinophil recruitment into the airways, thus suggesting an important role of Il25in enhancing allergic airway inflammation by a CD4+ T-cell-dependent mechanism.
Source : Human Cells
Species : Mouse
Tag : His
Predicted N Terminal : Gly
Form : Lyophilized from sterile PBS , pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Molecular Mass : The secreted recombinant mouse IL25 consists of 175 amino acids and has a calculated molecular mass of 20 kDa. As a result of glycosylation, rmIL25 migrates with the MW of approximately 30-35 kDa in SDS-PAGE under reducing conditions.
Protein length : 175 amino acids
Endotoxin : < 1.0 eu per 1μg of the protein as determined by the lal
Purity : >95%, as determined by SDS-PAGE
Stability : Samples are stable for up to twelve months from date of receipt at -70 °C.
Storage : Store it under sterile conditions at -70°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Gene Name : Il25 interleukin 25 [ Mus musculus ]
Official Symbol : Il25
Synonyms : IL25; interleukin 25; interleukin-25; interleukin 17E; Il17e; IL-17e;
Gene ID : 140806
mRNA Refseq : NM_080729
Protein Refseq : NP_542767
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function : cytokine activity; interleukin-17E receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Is there any research showing that IL-25 is effective in tumor treatment? 12/10/2022

There is a lack of conclusive evidence that IL-25 has a clear effect in tumor treatment, but there are some studies underway.

Are there any side effects to IL-25? 09/22/2021

There are no clear studies on the side effects of IL-25, but the patient response needs to be closely monitored during research and clinical application.

Has the study found potential applications of IL-25 in the treatment of other diseases? 01/18/2021

In addition to treating asthma and inflammatory bowel disease, IL-25 may also have potential applications in the treatment of lung infections, urticaria and other diseases.

What is the mechanism of action of IL-25? 12/18/2020

IL-25 activates specific signaling pathways by binding to specific receptors, thereby regulating the activity of immune cells and the degree of inflammation in the body.

Is there any research showing that IL-25 is effective against certain diseases? 08/17/2020

Some studies have shown that recombinant IL-25 can improve symptoms of diseases such as asthma and inflammatory bowel disease, but more research is needed to verify its efficacy.

Does IL-25 therapy need to be administered by injection? 03/28/2019

Yes, in general, IL-25 therapy needs to be administered by injection to ensure that the protein can enter the body and work.

Customer Reviews (3)

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Reviews
01/29/2021

    The activity is very strong and can meet my research needs.

    08/31/2019

      Price is very reasonable and good value for money.

      01/05/2019

        It is very stable and can be stored and used for a long time.

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