Active Recombinant Rat IL25 Protein

• Cat.No.: IL25-5209R
• Product Overview: Rat IL25 recombinant protein expressed in Escherichia coli.

Specification

• Description: The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. This cytokine can induce NF-kappaB activation, and stimulate the production of IL8. Both this cytokine and IL17B are ligands for the cytokine receptor IL17BR. Studies of the similar gene in mice suggested that this cytokine may be a proinflammatory cytokine favoring Th2-type immune response. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
• Source: E. coli
• Species: Rat
• Form: Lyophilized
• Bio-activity: The activity is determined by the dose-dependent induction of human IL-8 production from human PBMCs. The expected ED50 for this effect is 25-37.5 ng/mL.
• Molecular Mass: 35.5 kDa
• AA Sequence: MCSHLPRCCPSKQQEFPEEWLKWNP APVSPPEPLRHTHHPESCRASKDGP LNSRAISPWSYELDRDLNRVPQDLY HARCLCPHCVSLQTGSHMDPMGNSV PLYHNQTVFYRRPCHGEQGAHGRYC LERRLYRVSLACVCVRPRMMA
• Endotoxin: < 0.1 EU/μg
• Applications: Functional Study
  SDS-PAGE
• Storage: Store at -20 centigrade on dry atmosphere. After reconstitution with sterilized 20 mM HCl, store at -20 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: No additive
• Tag: Non

Gene Information

• Gene Name: Il25 interleukin 25 [ Rattus norvegicus ]
• Official Symbol: IL25
• Synonyms: IL25; interleukin 25; interleukin-25; RGD1561632
• Gene ID: 501996
• mRNA Refseq: NM_001192007
• Protein Refseq: NP_001178936

Reviews

01/29/2021

The activity is very strong and can meet my research needs.

08/31/2019

Price is very reasonable and good value for money.

01/05/2019

It is very stable and can be stored and used for a long time.

Q&As

Is there any research showing that IL-25 is effective in tumor treatment?

There is a lack of conclusive evidence that IL-25 has a clear effect in tumor treatment, but there are some studies underway.

Are there any side effects to IL-25?

There are no clear studies on the side effects of IL-25, but the patient response needs to be closely monitored during research and clinical application.

Has the study found potential applications of IL-25 in the treatment of other diseases?

In addition to treating asthma and inflammatory bowel disease, IL-25 may also have potential applications in the treatment of lung infections, urticaria and other diseases.

What is the mechanism of action of IL-25?

IL-25 activates specific signaling pathways by binding to specific receptors, thereby regulating the activity of immune cells and the degree of inflammation in the body.

Is there any research showing that IL-25 is effective against certain diseases?

Some studies have shown that recombinant IL-25 can improve symptoms of diseases such as asthma and inflammatory bowel disease, but more research is needed to verify its efficacy.

Does IL-25 therapy need to be administered by injection?

Yes, in general, IL-25 therapy needs to be administered by injection to ensure that the protein can enter the body and work.