Recombinant Full Length Human JAG1 Protein, C-Flag-tagged

• Cat.No.: JAG1-1115HFL
• Product Overview: Recombinant Full Length Human JAG1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter is involved in signaling processes. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 133.6 kDa
• AA Sequence: MRSPRTRGRSGRPLSLLLALLCALR AKVCGASGQFELEILSMQNVNGELQ NGNCCGGARNPGDRKCTRDE CDTYFKVCLKEYQSRVTAGGPCSFG SGSTPVIGGNTFNLKASRGNDRNRI VLPFSFAWPRSYTLLVEAWD SSNDTVQPDSIIEKASHSGMINPSR QWQTLKQNTGVAHFEYQIRVTCDDY YYGFGCNKFCRPRDDFFGHY ACDQNGNKTCMEGWMGPECNRAICR QGCSPKHGSCKLPGDCRCQYGWQGL YCDKCIPHPGCVHGICNEPW QCLCETNWGGQLCDKDLNYCGTHQP CLNGGTCSNTGPDKYQCSCPEGYSG PNCEIAEHACLSDPCHNRGS CKETSLGFECECSPGWTGPTCSTNI DDCSPNNCSHGGTCQDLVNGFKCVC PPQWTGKTCQLDANECEAKP CVNAKSCKNLIASYYCDCLPGWMGQ NCDININDCLGQCQNDASCRDLVNG YRCICPPGYAGDHCERDIDE CASNPCLNGGHCQNEINRFQCLCPT GFSGNLCQLDIDYCEPNPCQNGAQC YNRASDYFCKCPEDYEGKNC SHLKDHCRTTPCEVIDSCTVAMASN DTPEGVRYISSNVCGPHGKCKSQSG GKFTCDCNKGFTGTYCHENI NDCESNPCRNGGTCIDGVNSYKCIC SDGWEGAYCETNINDCSQNPCHNGG TCRDLVNDFYCDCKNGWKGK TCHSRDSQCDEATCNNGGTCYDEGD AFKCMCPGGWEGTTCNIARNSSCLP NPCHNGGTCVVNGESFTCVC KEGWEGPICAQNTNDCSPHPCYNSG TCVDGDNWYRCECAPGFAGPDCRIN INECQSSPCAFGATCVDEIN GYRCVCPPGHSGAKCQEVSGRPCIT MGSVIRDGAKWDDDCNTCQCLNGRI ACSKVWCGPRPCLLHKGHSE CPSGQSCIPILDDQCFVHPCTGVGE CRSSSLQPVKTKCTSDSYYQDNCAN ITFTFNKEMMSPGLTTEHIC SELRNLNILKNVSAEYSIYIACEPS PSANNEIHVAISAEDIRDDGNPIKE ITDKIIDLVSKRDGNSSLIA AVAEVRVQRRPLKNRTDFLVPLLSS VLTVAWICCLVTAFYWCLRKRRKPG SHTHSASEDNTTNNVREQLN QIKNPIEKHGANTVPIKDYENKNSK MSKIRTHNSEVEEDDMDKHQQKARF AKQPAYTLVDREEKPPNGTL
  TKHPNWTNKQDNRDLESAQSLNRME YIVTRTRPLEQKLISEEDLAANDIL DYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Notch signaling pathway

Gene Information

• Gene Name: JAG1 jagged canonical Notch ligand 1 [ Homo sapiens (human) ]
• Official Symbol: JAG1
• Synonyms: AGS; AHD; AWS; HJ1; AGS1; DCHE; CD339; JAGL1; CMT2HH
• Gene ID: 182
• mRNA Refseq: NM_000214.3
• Protein Refseq: NP_000205.1
• MIM: 601920
• UniProt ID: P78504