JAK2

  • Official Full Name

    JAK2 Janus kinase 2

  • Synonyms

    JAK2; Janus kinase 2; tyrosine-protein kinase JAK2; JTK10; JAK-2; Janus kinase 2 (a protein tyrosine kinase); THCYT3;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Human cells
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • C
  • His
  • DYKDDDDK
  • EPOR: N
  • terminal His
  • tag JAK2: N
  • terminal FLAG
  • tag
  • Flag
  • FLAG
  • Avi
  • GST
  • GST|His
  • His (Fc)
  • His|MBP
  • JAK2: N
  • tag EPOR: N
  • Myc
  • DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human JAK2-336H Active Recombinant Human JAK2 protein, GST-tagged Insect Cell GST
Human JAK2-81H Active Recombinant Human JAK2, GST-tagged Sf9 Insect Cell GST
Human JAK2-116H Active Recombinant Human JAK2(808-end) Protein, C-His-tagged Sf21 His 808-end
Human JAK2-157H Recombinant Human JAK2 protein, His/MBP-tagged E.coli His/MBP 1053-1132 aa
Human JAK2-532H Recombinant Human Janus Kinase 2, His-tagged Sf9 Insect Cell His
Human JAK2-27628TH Recombinant Human JAK2, His-tagged His
Human JAK2-27629TH Recombinant Human JAK2, His-tagged His
Human JAK2-158H Recombinant Human JAK2 protein, His/MBP-tagged E.coli His/MBP 121-361 aa
Human JAK2-57H Recombinant Human JAK2 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human JAK2-2487H Recombinant human Jak2, His-tagged E.coli His
Human JAK2-5441H Recombinant Human Janus Kinase 2, GST-His-tagged Sf9 Insect Cell GST/His
Human JAK2-28H Recombinant Human JAK2 Protein, FLAG/Avi-tagged, Biotin-labeled HEK293 FLAG/Avi 1-1132
Human JAK2-26H Recombinant Human JAK2 (W659A, W777A, F794H) (JH2 Domain) Protein, His/Avi-tagged, Biotin-labeled Insect Cell His/Avi 536-812
Human JAK2-5439H Recombinant Human Janus Kinase 2, GST-tagged Insect Cell GST
Human JAK2-598H Recombinant Human JAK2 protein, His-tagged E.coli His Asn508~Ala800
Human JAK2-250H Recombinant Human JAK2 Mammalian Cell His
Human JAK2-1420H Active Recombinant Human AMPX Protein, His-tagged Insect Cell His
Human JAK2-01H Recombinant Human JAK2 Protein, His-tagged E.coli His
Human JAK2-254H Recombinant Human JAK2 Protein, His-tagged E.coli His Asn508~Ala800
Human JAK2-3372H Recombinant Human JAK2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human JAK2-3128H Recombinant Human JAK2 protein, His-tagged E.coli His 752-1132aa
Human JAK2-151H Recombinant Human JAK2 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human JAK2-27H Recombinant Human JAK2 (V617F) Protein, FLAG/Avi-tagged, Biotin-labeled HEK293 FLAG/Avi 1-1132
Human JAK2-29H Recombinant Human JAK2 (JH1, JH2 domain) Protein, GST/Avi-tagged, Biotin-labeled HEK293 GST/Avi 513-1132
Human JAK2-33H Recombinant Human JAK2 (JH2 Domain) (W659A, W777A,F794H) Protein, His-tagged Insect Cell His 536-812
Human JAK2-22H Recombinant Human JAK2 (JH1, JH2 domain) Protein, His/GST-tagged Insect Cell His/GST 532-1132
Human JAK2-30H Recombinant Human JAK2 (V617F) (JH2 Domain) Protein, His/Avi-tagged, Biotin-labeled Insect Cell His/Avi 513-827
Human JAK2-31H Recombinant Human JAK2 (V617F) (JH1, JH2 Domain) Protein, GST/Avi-tagged HEK293 GST/Avi 513-1132
Human JAK2-34H Recombinant Human JAK2 (V617F, W659A, W777A, F794H) Mutation Protein, His-tagged Insect Cell His 536-812
Human JAK2-23H Active Recombinant Human JAK2 (JH1 domain) Protein, His-tagged Insect Cell His 808-1132
Human JAK2-32H Recombinant Human JAK2 (JH2 Domain) (E596A, V617F, W659A, W777A, F794H) Protein, His-tagged Insect Cell His 535-812
Human JAK2-36H Recombinant Human EPOR and JAK2 Fusion Protein, His/FLAG-tagged Insect Cell EPOR: N-terminal His-tag JAK2: N-terminal FLAG-tag EPOR: 273-338, JAK2: 36-1132(end)
Human JAK2-37H Recombinant Human JAK2 (V617F, W659A, W777A, F794H) Mutation Protein, His/Avi-Tag, Biotin-Labeled Insect Cell His/Avi 536-812
Human JAK2-24H Recombinant Human JAK2 (V617F) (JH1, JH2 Domain) Protein, GST/Avi-tagged, Biotin-labeled HEK293 GST/Avi 513-1132
Human JAK2-3184H-B Recombinant Human JAK2 Protein Pre-coupled Magnetic Beads HEK293
Human JAK2-3184H Recombinant Human JAK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human JAK2-35H Recombinant Human JAK2 and EPOR Fusion Protein, FLAG/His-tagged Insect Cell JAK2: N-terminal FLAG-tag EPOR: N-terminal His-tag JAK2: 26-1132(end), EPOR: 273-338
Human JAK2-25H Recombinant Human JAK2 (JH2 Domain) Protein, His/Avi-tagged, Biotin-labeled Insect Cell His/Avi 513-827
Human JAK2-177HFL Recombinant Full Length Human JAK2 Protein, C-Flag-tagged Mammalian cells Flag
Human JAK2-2477H Recombinant Human JAK2 protein(841-1130 aa), C-His-tagged E.coli C-His 841-1130 aa
Mouse Jak2-3627M Recombinant Mouse Jak2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Jak2-255M Recombinant Mouse Jak2 Protein, His-tagged E.coli His Phe120~Ser367
Rat JAK2-3136R Recombinant Rat JAK2 Protein Mammalian Cell His
Rat JAK2-2792R Recombinant Rat JAK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Jak2-257R Recombinant Rat Jak2 Protein, His-tagged E.coli His Thr689~Ser807
Rat JAK2-2792R-B Recombinant Rat JAK2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque JAK2-2327R Recombinant Rhesus monkey JAK2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque JAK2-2148R Recombinant Rhesus Macaque JAK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque JAK2-2148R-B Recombinant Rhesus Macaque JAK2 Protein Pre-coupled Magnetic Beads HEK293
Chicken JAK2-2252C Recombinant Chicken JAK2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • JAK2 Related Signal Pathway

JAK2 involved in several pathways and played different roles in them. We selected most pathways JAK2 participated on our site, such as AGE/RAGE pathway, ARMS-mediated activation, Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with JAK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AGE/RAGE pathwayDDOST;JAK2;TIRAP;CHUK;LGALS3;EGFR;MMP13;JUN;DIAPH1
ARMS-mediated activationDUSP1;DUSP7;JAK2;DUSP4;EGF;FGFR1B;SPTA1;PSMD10;PSMD14
Adipocytokine signaling pathwaySLC2A4;SOCS3B;ACSL4A;CHUK;G6PC;PPARA;TNFRSF1B;ADIPOQ;LEPR
Axon guidanceITGB1;CSNK2B;SEMA4C;AP2A2;COL6A2;SEMA4A;PAK4;SPTB;TRPC4
BDNF signaling pathwayIGF2BP1;EGR1;GNB2L1;LINGO1;YBX1;JAK2;EGR2;MAP3K2;FRS2
CXCR4-mediated signaling eventsPAG1;MAPKAP1;CSK;GNA13;JAK2;CFL1;ARR3;CRK;DNM1
Chemokine signaling pathwayPLCB3;CXCL2;CCL3L3;NFKBIA;GNAI2;CXCL6;GNAI3;RLN1;ITK
Cholinergic synapseGNB2;CREB3L4;GNAI3;KCNQ4;PIK3CG;GNG8;CAMK2B;ITPR3;PRKCA

JAK2 has several biochemical functions, for example, ATP binding, SH2 domain binding, acetylcholine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by JAK2 itself. We selected most functions JAK2 had, and list some proteins which have the same functions with JAK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingFGFR2;CDK19;OBSCN;SGK2;UBE2D1;ABCC8;TNNI3K;NADKD1;NARS
SH2 domain bindingSKAP1;PTK2;SRC;SIT1;AFAP1L2;SH3PXD2B;SYNGR3;PAG1;NUP62
acetylcholine receptor bindingJAK2;RIC3;RER1;NRXN1;RAPSN;APP;DLG4;UBXN2A;KCNS1
growth hormone receptor bindingJAK2;TYK2;GH1;JAK1;SOCS2;Gh
heme bindingCYP21A2;PTGS1;CYP2U1;CYP2W1;CYP2C38;CYB5R4;HBZ;HBB;HBAA1
histone bindingUHRF1;HIST1H4N;SMARCA2;HIST1H3H;H2AFX;WDTC1;HIST1H4F;H3F3A;HIST3H3
histone kinase activity (H3-Y41 specific)
insulin receptor substrate bindingIGF1RA;INSRR;GRB2;INSR;PIK3CB;PTPN11;PIK3CA;JAK2;IGF1R
interleukin-12 receptor bindingIL12A;JAK2;IL12B;IL12BA
non-membrane spanning protein tyrosine kinase activityJAK2A;PTK2;JAK1;MELK;FER;FGR;PTK6B;RIPK2;DYRK1A
peptide hormone receptor bindingNPPA;JAK2;NPPC;LEP;PTH;PTHLHA;PTPN11;PTHLH;FYN
phosphatidylinositol 3-kinase bindingINSRB;IGF1RB;DAB1;CALM3;IRS1;CALM1;JAK2;LCK;INSR
protein C-terminus bindingJAK2;NIPBL;EFHC1;LIG4;VTA1;ITGB3BP;TJP2;PPP2CB;IFT52
protein bindingPPP2R5B;DOCK1;TTC25;MMS22L;CRYAA;BCL7B;SNAPIN;ZBTB43;CPNE1
protein kinase activityJAK2A;DYRK1A;PTK2AA;FGFR1A;TRIO;LIMK1;KITA;CCL8;PIK3CG
protein kinase bindingLCK;STK11IP;BCL2L14;SPRY2;NEK6;KCNA5;NEFH;CCNK;RAB8A
protein tyrosine kinase activityPTK2AB;ALK;AXL;FYNB;KIT;FYN;CSK;SHC1;PTK7
receptor bindingTMEM38A;SMARCD1;RND1;FIS1;TMED1;HMGCL;HACL1;SLC9A3R1;ICOSLG
type 1 angiotensin receptor bindingTYK2;BDKRB2;GNG3;GNA13B;JAK2;AGT;ARAP1;GNB1;GNA13A

JAK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JAK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of JAK2.

PTPN1; CSF2RB; MPL; SH2B1; saicar; EGFR; PKM

Gene Family

TGF Cytokines

Research Area

Related articles

Rath, T; Billmeier, U; et al. From physiology to disease and targeted therapy: interleukin-6 in inflammation and inflammation-associated carcinogenesis. ARCHIVES OF TOXICOLOGY 89:541-554(2015).
Lan, HN; Jiang, HL; et al. Development and Characterization of a Novel Anti-idiotypic Monoclonal Antibody to Growth Hormone, Which Can Mimic Physiological Functions of Growth Hormone in Primary Porcine Hepatocytes. ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES 28:573-583(2015).
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  • Q&As

Customer Reviews (3)

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10/03/2020

    Quick response from customer service.

    05/12/2020

      Product performed as expected.

      08/07/2018

        Satisfied with product quality.

        Q&As (7)

        Ask a question
        What role does JAK2 play in myeloproliferative neoplasms (MPNs)? 11/17/2022

        JAK2 mutations, particularly JAK2 V617F, are hallmarks of several MPNs, including polycythemia vera, essential thrombocythemia, and primary myelofibrosis. These mutations lead to uncontrolled cell proliferation.

        How does JAK2 activation lead to downstream signal transduction? 02/26/2022

        Upon cytokine binding to its receptor, JAK2 becomes activated through phosphorylation. This activation leads to the phosphorylation and activation of STAT (Signal Transducers and Activators of Transcription) proteins, which then translocate to the nucleus and regulate gene expression.

        What is the primary function of the JAK2 protein in cellular signaling? 10/19/2021

        JAK2 is a non-receptor tyrosine kinase that plays a pivotal role in cytokine signaling, mediating cellular responses to growth factors and various cytokines.

        How is JAK2 involved in hematopoiesis and blood cell development? 04/21/2021

        JAK2 is crucial for hematopoiesis, especially in the signaling pathways of erythropoietin and thrombopoietin, which are essential for red blood cell and platelet production, respectively.

        How does JAK2 interact with cytokine receptors, and what is its significance? 10/29/2020

        JAK2 associates with the intracellular domains of specific cytokine receptors. Upon cytokine binding, JAK2 becomes activated, leading to downstream signaling events. This interaction is vital for mediating cellular responses to various cytokines.

        Are there therapeutic agents that target JAK2, and in what contexts are they used? 03/11/2019

        Yes, there are several JAK2 inhibitors, such as ruxolitinib and fedratinib, which are used to treat MPNs. They work by inhibiting the kinase activity of JAK2, thereby reducing aberrant cell proliferation.

        Are there known mutations in the JAK2 gene, and what are their implications? 02/06/2018

        Yes, one of the most well-known mutations is JAK2 V617F, which results in constitutive activation of the kinase. This mutation is associated with various myeloproliferative neoplasms (MPNs).

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