JAK2 Protein

JAK2

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JAK2

Official Full Name JAK2 Janus kinase 2
Synonyms JAK2; Janus kinase 2; tyrosine-protein kinase JAK2; JTK10; JAK-2; Janus kinase 2 (a protein tyrosine kinase); THCYT3;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Human cells
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Sf9 Insect Cell
    • Tag :
    • DYKDDDDK
    • EPOR: N-terminal His-tag JAK2: N-terminal FLAG-tag
    • Flag
    • FLAG/Avi
    • GST
    • GST/Avi
    • His
    • His (Fc)-Avi
    • His/Avi
    • His/GST
    • MBP
    • JAK2: N-terminal FLAG-tag EPOR: N-terminal His-tag
    • Myc/DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human JAK2-336H Active Recombinant Human JAK2 protein, GST-tagged Insect Cell GST Inquiry
    Human JAK2-81H Active Recombinant Human JAK2, GST-tagged Sf9 Insect Cell GST Inquiry
    Human JAK2-1420H Recombinant Human AMPX Protein, His-tagged Insect Cell His Inquiry
    Human JAK2-157H Recombinant Human JAK2 protein, His/MBP-tagged E.coli His/MBP Inquiry
    Human JAK2-158H Recombinant Human JAK2 protein, His/MBP-tagged E.coli His/MBP Inquiry
    Human JAK2-2487H Recombinant human Jak2, His-tagged E.coli His Inquiry
    Human JAK2-250H Recombinant Human JAK2 Mammalian Cell His Inquiry
    Human JAK2-26H Recombinant Human JAK2 (W659A, W777A, F794H) (JH2 Domain) Protein, His/Avi-tagged, Biotin-labeled Insect Cell His/Avi Inquiry
    Human JAK2-27628TH Recombinant Human JAK2, His-tagged His Inquiry
    Human JAK2-27629TH Recombinant Human JAK2, His-tagged His Inquiry
    Human JAK2-28H Recombinant Human JAK2 Protein, FLAG/Avi-tagged, Biotin-labeled HEK293 FLAG/Avi Inquiry
    Human JAK2-532H Recombinant Human Janus Kinase 2, His-tagged Sf9 Insect Cell His Inquiry
    Human JAK2-5439H Recombinant Human Janus Kinase 2, GST-tagged Insect Cell GST Inquiry
    Human JAK2-5441H Recombinant Human Janus Kinase 2, GST-His-tagged Sf9 Insect Cell GST/His Inquiry
    Human JAK2-57H Recombinant Human JAK2 protein, Flag-tagged, Biotinylated Insect Cell Flag Inquiry
    Human JAK2-598H Recombinant Human JAK2 protein, His-tagged E.coli His Inquiry
    Rat JAK2-3136R Recombinant Rat JAK2 Protein Mammalian Cell His Inquiry
    Rhesus Macaque JAK2-2327R Recombinant Rhesus monkey JAK2 Protein, His-tagged Mammalian Cell His Inquiry
    Chicken JAK2-2252C Recombinant Chicken JAK2 Mammalian Cell His Inquiry
    Human JAK2-1228H Recombinant Human JAK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human JAK2-151H Recombinant Human JAK2 Protein, DYKDDDDK-tagged Human cells DYKDDDDK Inquiry
    Human JAK2-177HFL Recombinant Full Length Human JAK2 Protein, C-Flag-tagged Mammalian cells Flag Inquiry
    Rhesus Macaque JAK2-2148R Recombinant Rhesus Macaque JAK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human JAK2-22H Recombinant Human JAK2 (JH1, JH2 domain) Protein, His/GST-tagged Insect Cell His/GST Inquiry
    Human JAK2-23H Recombinant Human JAK2 (JH1 domain) Protein, His-tagged Insect Cell His Inquiry
    Human JAK2-24H Recombinant Human JAK2 (V617F) (JH1, JH2 Domain) Protein, GST/Avi-tagged, Biotin-labeled HEK293 GST/Avi Inquiry
    Human JAK2-25H Recombinant Human JAK2 (JH2 Domain) Protein, His/Avi-tagged, Biotin-labeled Insect Cell His/Avi Inquiry
    Rat JAK2-2792R Recombinant Rat JAK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human JAK2-27H Recombinant Human JAK2 (V617F) Protein, FLAG/Avi-tagged, Biotin-labeled HEK293 FLAG/Avi Inquiry
    Human JAK2-29H Recombinant Human JAK2 (JH1, JH2 domain) Protein, GST/Avi-tagged, Biotin-labeled HEK293 GST/Avi Inquiry
    Human JAK2-30H Recombinant Human JAK2 (V617F) (JH2 Domain) Protein, His/Avi-tagged, Biotin-labeled Insect Cell His/Avi Inquiry
    Human JAK2-3128H Recombinant Human JAK2 protein, His-tagged E.coli His Inquiry
    Human JAK2-3184H Recombinant Human JAK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human JAK2-31H Recombinant Human JAK2 (V617F) (JH1, JH2 Domain) Protein, GST/Avi-tagged HEK293 GST/Avi Inquiry
    Human JAK2-32H Recombinant Human JAK2 (JH2 Domain) (E596A, V617F, W659A, W777A, F794H) Protein, His-tagged Insect Cell His Inquiry
    Human JAK2-33H Recombinant Human JAK2 (JH2 Domain) (W659A, W777A,F794H) Protein, His-tagged Insect Cell His Inquiry
    Human JAK2-34H Recombinant Human JAK2 (V617F, W659A, W777A, F794H) Mutation Protein, His-tagged Insect Cell His Inquiry
    Human JAK2-35H Recombinant Human JAK2 and EPOR Fusion Protein, FLAG/His-tagged Insect Cell JAK2: N-terminal FLAG-tag EPOR: N-terminal His-tag Inquiry
    Human JAK2-36H Recombinant Human EPOR and JAK2 Fusion Protein, His/FLAG-tagged Insect Cell EPOR: N-terminal His-tag JAK2: N-terminal FLAG-tag Inquiry
    Human JAK2-37H Recombinant Human JAK2 (V617F, W659A, W777A, F794H) Mutation Protein, His/Avi-Tag, Biotin-Labeled Insect Cell His/Avi Inquiry
    Human JAK2-01H Recombinant Human JAK2 Protein, His-tagged E. coli His Inquiry
    Human JAK2-254H Recombinant Human JAK2 Protein, His-tagged E.coli His Inquiry
    Human JAK2-3372H Recombinant Human JAK2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Mouse Jak2-255M Recombinant Mouse Jak2 Protein, His-tagged E.coli His Inquiry
    Mouse Jak2-3627M Recombinant Mouse Jak2 Protein, Myc/DDK-tagged HEK293T Myc/DDK Inquiry
    Rat Jak2-257R Recombinant Rat Jak2 Protein, His-tagged E.coli His Inquiry

    JAK2 involved in several pathways and played different roles in them. We selected most pathways JAK2 participated on our site, such as AGE/RAGE pathway, ARMS-mediated activation, Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with JAK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    AGE/RAGE pathway ATF2; EGFR; MAPK14; DIAPH1; DDOST; TIRAP; LGALS3; CHUK; JUN; AGER
    ARMS-mediated activation FGF8B; CSF2RA; SPTA1; SLC14A2; CSK; FGF18B; PSME3; NRG4; NRG3; SPNA2
    Adipocytokine signaling pathway IRS4; AKT3A; NFKBIAA; JAK2; NFKBIB; ACSBG1; RXRG; AKT2L; MAPK8; CAMKK2
    Axon guidance ABLIM3; RGS3; NFATC4; COL6A2; RAC2; CFL2; SDCBP; GDNF; FGFR1B; PEA15A
    BDNF signaling pathway SYN1; MAP3K2; DOK5; YBX1; EIF4EBP1; EEF2; JAK2; CSNK2A1; EIF4E; GNB2L1
    CXCR4-mediated signaling events CRK; ADRBK1; PAG1; CFL1; GNA13; MAPKAP1; GNB2L1; JAK2; DNM1; BLK
    Chemokine signaling pathway GM1987; GM13306; GNGT2; PARD3; STAT5B; VAV3; CCR1; STAT1; CXCR2; CXCL14
    Cholinergic synapse MAPK1; CHRNA4; CHRM1; GNG13; GNAQ; CHRM5; PRKACB; KCNQ1; KRAS; PIK3CG

    JAK2 has several biochemical functions, for example, ATP binding, SH2 domain binding, acetylcholine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by JAK2 itself. We selected most functions JAK2 had, and list some proteins which have the same functions with JAK2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding STK32C; CHUK; KIF3A; RAD54L; EHD2; UBE2I; NLRP14; GM7168; NME4; CLK2B
    SH2 domain binding INPPL1; ARHGAP5; KHDRBS2; TRPV4; NLK; SKAP1; LILRB1; CRK; SYP; PAG1
    acetylcholine receptor binding APP; RIC3; KCNS1; RAPSN; RER1; DLG4; NRXN1; UBXN2A; JAK2
    growth hormone receptor binding JAK2; Gh; JAK1; SOCS2; GH1; TYK2
    heme binding CYP21A2; DUOX2; CYP1B1; CYP4F11; CYP7A1; HBAE1; MFSD7C; CYP19A1B; CYP4F14; MB
    histone binding H3F3A; ZMYND11; BAZ2A; CTSL1; SUPT6H; PRKCBP1L; CHD2; HINFP; WDTC1; RCC1
    histone kinase activity (H3-Y41 specific) JAK2
    insulin receptor substrate binding PRKCD; INSR; GRB2; INSRB; PIK3R1; IGF1RA; PIK3CB; PRKCZ; IGF1R; INSRR
    interleukin-12 receptor binding JAK2; IL12A; IL12BA; IL12B
    non-membrane spanning protein tyrosine kinase activity YRK; LCK; RIPK2; SYK; TNK2; ABL2; WEE2; BMX; DYRK1A; JAK2A
    peptide hormone receptor binding RUNDC3A; PTHLH; FYN; LEP; NPPA; ADCYAP1; JAK2; NPPC; PTPN11; PTH
    phosphatidylinositol 3-kinase binding IGF1RB; BECN1; IRS1; ATP1A1; DAB1; FYN; FLT3; HCST; IGF1R; IRS4
    protein C-terminus binding VIM; ZBTB16; PCGF1; NPAT; PIAS3; SNX17; SIRT1; JAK2; NEIL1; PDZD11
    protein binding STX3; AMFR; LHX4; POLR1B; CHRAC1; PSMB9; URI1; SPTSSA; LANCL1; HYPM
    protein kinase activity RIPK1L; EPHA4; EPHA1; DCLK2; SRPK1A; MAP3K12; GC3; CDK8; PAK4; MMD2
    protein kinase binding LLGL1; SLC12A4; HDAC4; RFFL; H2AFY; BCAR1; ERRFI1; CDK5RAP2; AXIN1; PAK2
    protein tyrosine kinase activity JAK3; MET; TESK1; EPHA2A; HCK; ZAP70; ERBB4A; MATK; PTK2BB; MAP2K4
    receptor binding APOL2; ANKRD13C; ACOX3; TENM2; EDA; EFNA1; PLAUR; WNT11R; CLCF1; GLA
    type 1 angiotensin receptor binding GNA13A; BDKRB2; ARRB2; GNB1; ARAP1; TYK2; GNA13B; GNA13; AGT; JAK2

    JAK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JAK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of JAK2.

    PTPN1; CSF2RB; MPL; SH2B1; saicar; EGFR; PKM

    Rath, T; Billmeier, U; et al. From physiology to disease and targeted therapy: interleukin-6 in inflammation and inflammation-associated carcinogenesis. ARCHIVES OF TOXICOLOGY 89:541-554(2015).
    Lan, HN; Jiang, HL; et al. Development and Characterization of a Novel Anti-idiotypic Monoclonal Antibody to Growth Hormone, Which Can Mimic Physiological Functions of Growth Hormone in Primary Porcine Hepatocytes. ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES 28:573-583(2015).

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