JAK2
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Official Full Name
JAK2 Janus kinase 2
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Synonyms
JAK2; Janus kinase 2; tyrosine-protein kinase JAK2; JTK10; JAK-2; Janus kinase 2 (a protein tyrosine kinase); THCYT3;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Human
- Mouse
- Rat
- Rhesus Macaque
- E. coli
- E.coli
- HEK293
- HEK293T
- Human cells
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf21
- Sf9 Insect Cell
- C
- His
- DYKDDDDK
- EPOR: N
- terminal His
- tag JAK2: N
- terminal FLAG
- tag
- Flag
- FLAG
- Avi
- GST
- GST|His
- His (Fc)
- His|MBP
- JAK2: N
- tag EPOR: N
- Myc
- DDK
- Involved Pathway
- Protein Function
- Interacting Protein
- JAK2 Related Articles
- JAK2 Related Gene Family
- JAK2 Related Research Area
- JAK2 Related Signal Pathway
JAK2 involved in several pathways and played different roles in them. We selected most pathways JAK2 participated on our site, such as AGE/RAGE pathway, ARMS-mediated activation, Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with JAK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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AGE/RAGE pathway | CHUK;TIRAP;JUN;EGFR;MMP13;LGALS3;ATF2;DIAPH1;JAK2 |
ARMS-mediated activation | DUSP10;JAK2;PEA15;CSK;DUSP7;DUSP9;PSMD5;RASGEF1A;SPRED2 |
Adipocytokine signaling pathway | PPARGC1A;AGRP;ACSL3A;SLC2A1;JAK2A;ACACB;AKT1;IKBKG;PTPN11 |
Axon guidance | GFRA4;ITGB1B.1;ST8SIA2;RASA1;CNKSR1;SDCBP;SEMA6C;SLIT2;RASGRP4 |
BDNF signaling pathway | SYN1;DPYSL2;MAP3K2;EEF2;CDKL5;CDK5;LINGO1;SIRPA;CSNK2A1P |
CXCR4-mediated signaling events | CRK;ADRBK1;GNB2L1;BLK;ARR3;CFL1;GNA13;PAG1;DNM1 |
Chemokine signaling pathway | CXCL10;GNG7;PIK3CD;CRK;RAC2;GNGT1;PXN;GM2506;IKBKG |
Cholinergic synapse | PRKACG;GNG11;CHRM5;PIK3R5;GNB1;SLC5A7;GNG7;PIK3CB;PIK3CA |
JAK2 has several biochemical functions, for example, ATP binding, SH2 domain binding, acetylcholine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by JAK2 itself. We selected most functions JAK2 had, and list some proteins which have the same functions with JAK2. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | PKM2;EIF4A1A;SMC6;SRPK2;RPS6KA1;DDX58;PTK2AB;SMARCA2;GATB |
SH2 domain binding | PTK2;DLC1;CTR9;IRS1;GNB2L1;SHCBP1;LAX1;SQSTM1;AFAP1L2 |
acetylcholine receptor binding | UBXN2A;KCNS1;RER1;JAK2;DLG4;APP;NRXN1;RAPSN;RIC3 |
growth hormone receptor binding | Gh;GH1;JAK2;TYK2;SOCS2;JAK1 |
heme binding | HBAD;MB;CYP20A1;HBG2;PGRMC2;GUCY1A3;CYP2W1;IDO1;CYP4V8 |
histone binding | TBL1XR1;NCL;HIST1H4L;SNCA;CHD2;ANP32B;WDTC1;HIST1H3G;HIST1H3I |
histone kinase activity (H3-Y41 specific) | |
insulin receptor substrate binding | PTPN11;PRKCD;PIK3CA;INSRR;PIK3R1;GRB2;PIK3CB;IGF1RB;IGF1RA |
interleukin-12 receptor binding | JAK2;IL12BA;IL12A;IL12B |
non-membrane spanning protein tyrosine kinase activity | LCK;BAZ1B;MELK;STYK1;MATK;FER;SRMS;FYNA;YRK |
peptide hormone receptor binding | ADCYAP1;NPPA;PTHLH;FYN;NPPC;PTHLHA;JAK2;PTH;RUNDC3A |
phosphatidylinositol 3-kinase binding | INSRA;PDGFRB;CORO1A;ATP1A1;IRS1;PIK3R1;INSR;IGF1RA;IGF1R |
protein C-terminus binding | VTA1;TOP2B;BLOC1S2;DYNLL1;SCLT1;PEX12;DGKZ;SDC1;RABAC1 |
protein binding | NOS1;SPSB3;STOML2;RAB25;GCHFR;FABP3;DAZAP2;CASP9;NCBP1 |
protein kinase activity | CAMKK1B;CDC42BPB;RNASEL;MAP3K3;STK26;RAF1B;MAP3K11;ROCK2A;ARAF |
protein kinase binding | PARK2;DBF4B;PPP1R12B;GATA4;MAPK8IP2;FBXO7;BORA;LATS1;DPYSL2 |
protein tyrosine kinase activity | EPHA4B;FYN;ERBB4;CLK3;MAP2K5;INSR;BTK;Fert2;BCR |
receptor binding | F2R;WIPI1;PPP2R4;HFE;BMP3;PGR;NRG1;ZAP70;SRMS |
type 1 angiotensin receptor binding | AGT;ARRB2;ARAP1;GNG3;GNA13B;TYK2;GNA13;GNA13A;JAK2 |
JAK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JAK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of JAK2.
PTPN1; CSF2RB; MPL; SH2B1; saicar; EGFR; PKM
- Q&As
- Reviews
Q&As (7)
Ask a questionJAK2 mutations, particularly JAK2 V617F, are hallmarks of several MPNs, including polycythemia vera, essential thrombocythemia, and primary myelofibrosis. These mutations lead to uncontrolled cell proliferation.
Upon cytokine binding to its receptor, JAK2 becomes activated through phosphorylation. This activation leads to the phosphorylation and activation of STAT (Signal Transducers and Activators of Transcription) proteins, which then translocate to the nucleus and regulate gene expression.
JAK2 is a non-receptor tyrosine kinase that plays a pivotal role in cytokine signaling, mediating cellular responses to growth factors and various cytokines.
JAK2 is crucial for hematopoiesis, especially in the signaling pathways of erythropoietin and thrombopoietin, which are essential for red blood cell and platelet production, respectively.
JAK2 associates with the intracellular domains of specific cytokine receptors. Upon cytokine binding, JAK2 becomes activated, leading to downstream signaling events. This interaction is vital for mediating cellular responses to various cytokines.
Yes, there are several JAK2 inhibitors, such as ruxolitinib and fedratinib, which are used to treat MPNs. They work by inhibiting the kinase activity of JAK2, thereby reducing aberrant cell proliferation.
Yes, one of the most well-known mutations is JAK2 V617F, which results in constitutive activation of the kinase. This mutation is associated with various myeloproliferative neoplasms (MPNs).
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