JAK2 Protein

JAK2

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JAK2

Official Full Name JAK2 Janus kinase 2
Synonyms JAK2; Janus kinase 2; tyrosine-protein kinase JAK2; JTK10; JAK-2; Janus kinase 2 (a protein tyrosine kinase); THCYT3;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Human cells
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • DYKDDDDK
    • EPOR: N-terminal His-tag JAK2: N-terminal FLAG-tag
    • Flag
    • FLAG/Avi
    • GST
    • GST/Avi
    • His
    • His/Avi
    • His/GST
    • MBP
    • JAK2: N-terminal FLAG-tag EPOR: N-terminal His-tag
    • Myc/DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human JAK2-1420H Recombinant Human AMPX Protein, His-tagged Insect Cell His
    Human JAK2-157H Recombinant Human JAK2 protein, His/MBP-tagged E.coli His/MBP
    Human JAK2-158H Recombinant Human JAK2 protein, His/MBP-tagged E.coli His/MBP
    Human JAK2-2487H Recombinant human Jak2, His-tagged E.coli His
    Human JAK2-250H Recombinant Human JAK2 Mammalian Cell His
    Human JAK2-26H Recombinant Human JAK2 (W659A, W777A, F794H) (JH2 Domain) Protein, His/Avi-tagged, Biotin-labeled Insect Cell His/Avi
    Human JAK2-27628TH Recombinant Human JAK2, His-tagged His
    Human JAK2-27629TH Recombinant Human JAK2, His-tagged His
    Human JAK2-28H Recombinant Human JAK2 Protein, FLAG/Avi-tagged, Biotin-labeled HEK293 FLAG/Avi
    Human JAK2-336H Recombinant Human JAK2 protein, GST-tagged Insect Cell GST
    Human JAK2-532H Recombinant Human Janus Kinase 2, His-tagged Sf9 Insect Cell His
    Human JAK2-5439H Recombinant Human Janus Kinase 2, GST-tagged Insect Cell GST
    Human JAK2-5441H Recombinant Human Janus Kinase 2, GST-His-tagged Sf9 Insect Cell GST/His
    Human JAK2-57H Recombinant Human JAK2 protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human JAK2-598H Recombinant Human JAK2 protein, His-tagged E.coli His
    Human JAK2-81H Recombinant Human JAK2, GST-tagged Sf9 Insect Cell GST
    Rat JAK2-3136R Recombinant Rat JAK2 Protein Mammalian Cell His
    Rhesus Macaque JAK2-2327R Recombinant Rhesus monkey JAK2 Protein, His-tagged Mammalian Cell His
    Chicken JAK2-2252C Recombinant Chicken JAK2 Mammalian Cell His
    Human JAK2-151H Recombinant Human JAK2 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
    Human JAK2-22H Recombinant Human JAK2 (JH1, JH2 domain) Protein, His/GST-tagged Insect Cell His/GST
    Human JAK2-23H Recombinant Human JAK2 (JH1 domain) Protein, His-tagged Insect Cell His
    Human JAK2-24H Recombinant Human JAK2 (V617F) (JH1, JH2 Domain) Protein, GST/Avi-tagged, Biotin-labeled HEK293 GST/Avi
    Human JAK2-25H Recombinant Human JAK2 (JH2 Domain) Protein, His/Avi-tagged, Biotin-labeled Insect Cell His/Avi
    Human JAK2-27H Recombinant Human JAK2 (V617F) Protein, FLAG/Avi-tagged, Biotin-labeled HEK293 FLAG/Avi
    Human JAK2-29H Recombinant Human JAK2 (JH1, JH2 domain) Protein, GST/Avi-tagged, Biotin-labeled HEK293 GST/Avi
    Human JAK2-30H Recombinant Human JAK2 (V617F) (JH2 Domain) Protein, His/Avi-tagged, Biotin-labeled Insect Cell His/Avi
    Human JAK2-3128H Recombinant Human JAK2 protein, His-tagged E.coli His
    Human JAK2-31H Recombinant Human JAK2 (V617F) (JH1, JH2 Domain) Protein, GST/Avi-tagged HEK293 GST/Avi
    Human JAK2-32H Recombinant Human JAK2 (JH2 Domain) (E596A, V617F, W659A, W777A, F794H) Protein, His-tagged Insect Cell His
    Human JAK2-33H Recombinant Human JAK2 (JH2 Domain) (W659A, W777A,F794H) Protein, His-tagged Insect Cell His
    Human JAK2-34H Recombinant Human JAK2 (V617F, W659A, W777A, F794H) Mutation Protein, His-tagged Insect Cell His
    Human JAK2-35H Recombinant Human JAK2 and EPOR Fusion Protein, FLAG/His-tagged Insect Cell JAK2: N-terminal FLAG-tag EPOR: N-terminal His-tag
    Human JAK2-36H Recombinant Human EPOR and JAK2 Fusion Protein, His/FLAG-tagged Insect Cell EPOR: N-terminal His-tag JAK2: N-terminal FLAG-tag
    Human JAK2-37H Recombinant Human JAK2 (V617F, W659A, W777A, F794H) Mutation Protein, His/Avi-Tag, Biotin-Labeled Insect Cell His/Avi
    Human JAK2-01H Recombinant Human JAK2 Protein, His-tagged E. coli His
    Human JAK2-254H Recombinant Human JAK2 Protein, His-tagged E.coli His
    Human JAK2-3372H Recombinant Human JAK2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Jak2-255M Recombinant Mouse Jak2 Protein, His-tagged E.coli His
    Mouse Jak2-3627M Recombinant Mouse Jak2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat Jak2-257R Recombinant Rat Jak2 Protein, His-tagged E.coli His

    JAK2 involved in several pathways and played different roles in them. We selected most pathways JAK2 participated on our site, such as AGE/RAGE pathway, ARMS-mediated activation, Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with JAK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    AGE/RAGE pathway AGER; TIRAP; CHUK; MMP13; EGFR; DIAPH1; LGALS3; MAPK14; JAK2; DDOST
    ARMS-mediated activation DUSP1; KLB; LAMTOR2; SPTA1; DUSP10; DUSP5; PSMA8; CSF2RA; NETO2; NRG3
    Adipocytokine signaling pathway MTOR; CPT1C; MAPK8A; CHUK; IRS4; ACSL4; RXRGA; NFKBIAA; NFKBIB; PRKAA2
    Axon guidance SPTBN1; CAP2; ABLIM2; SPTBN2; NRG4; SEMA3G; TRPC5; CXCR4; PTK2; RHOA
    BDNF signaling pathway EIF2S1; EEF2; DPYSL2; EGR1; CSNK2A1; CDK5; KCNN2; EGR2; GRIP1; SYN1
    CXCR4-mediated signaling events JAK2; BLK; CRK; ARR3; ADRBK1; MAPKAP1; GNB2L1; PAG1; DNM1; CSK
    Chemokine signaling pathway CCR9; CXCL3; PREX1; GRK4; RASGRP2; ARRB1; CXCL13; PARD3; GM13304; BRAF
    Cholinergic synapse KCNQ5; CHRNA6; PRKCA; CAMK2B; GNAI1; CHAT; KCNQ4; GNAO1; ITPR3; FOS

    JAK2 has several biochemical functions, for example, ATP binding, SH2 domain binding, acetylcholine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by JAK2 itself. We selected most functions JAK2 had, and list some proteins which have the same functions with JAK2. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding DDX49; EPHA4; ACTR2B; RFC4; ABCC5; STK10; PRKCDA; ABCA1; PIK3C2B; ERBB3
    SH2 domain binding TRPV4; NLK; INPPL1; CTR9; DAG1; SKAP1; SYP; DLC1; GNB2L1; ARHGAP5
    acetylcholine receptor binding NRXN1; RAPSN; RIC3; RER1; UBXN2A; DLG4; JAK2; KCNS1; APP
    growth hormone receptor binding Gh; TYK2; JAK1; JAK2; GH1; SOCS2
    heme binding CYP2J5; CYP2C19; CYP4F12; TDO2; CYP3A25; CYP2C18; HBBE3; CYP26C1; HBE; NGB
    histone binding CTCFL; HIST1H4E; CTSL1; HIST2H4; RNF168; NASP; HIST1H3F; HIST1H4H; CHAF1B; SMARCA2
    histone kinase activity (H3-Y41 specific) JAK2
    insulin receptor substrate binding PIK3CA; PIK3R1; IGF1R; PRKCD; PTPN11; INSR; INSRR; INSRB; GRB2; PRKCZ
    interleukin-12 receptor binding IL12BA; IL12A; JAK2; IL12B
    non-membrane spanning protein tyrosine kinase activity PTK2AB; ABL1; YES1; STK16; RIPK2; JAK2B; FER; PTK2B; PTK2; PTK2BB
    peptide hormone receptor binding FYN; NPPA; JAK2; NPPC; PTH; PTPN11; LEP; PTHLH; ADCYAP1; PTHLHA
    phosphatidylinositol 3-kinase binding INSR; JAK2; IGF1RA; INSRB; INSRA; LCK; TYRO3; CORO1A; IGF1R; HCST
    protein C-terminus binding PEX10; ZBTB16; VTA1; HIC2; DLG3; PROP1; SAE1; TNNI3K; CAV3; BLOC1S2A
    protein binding AGXT2L2; CALM1; AMOTL2; ZNRF1; ZBTB25; RPS6KA1; RTN4R; SPEF1; TMEM106B; VGLL2
    protein kinase activity PKZ; PRKCBA; CAMK2D1; CDKL5; CDKL2; STK4; IGF1RB; NEK1; CAMK1GA; BSK146
    protein kinase binding TPRKB; CDC25B; KIF13B; PRKCZ; EEF1A1; PTPRK; STX1B; PLCG1; SQSTM1; PPP1CB
    protein tyrosine kinase activity FES; KITA; MAP3K9; FGFR1OP; ZAP70; MAP2K3; JAK2A; CSK; DYRK3; IGF1RB
    receptor binding ACOX3; HNF4A; TGFB2; FGF11; FGF8A; CNTFR; KCNJ10; F2R; HLA-E; SEMA4D
    type 1 angiotensin receptor binding JAK2; TYK2; AGT; GNG3; BDKRB2; ARRB2; GNA13A; GNA13B; ARAP1; GNB1

    JAK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JAK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of JAK2.

    PTPN1; CSF2RB; MPL; SH2B1; saicar; EGFR; PKM

    Rath, T; Billmeier, U; et al. From physiology to disease and targeted therapy: interleukin-6 in inflammation and inflammation-associated carcinogenesis. ARCHIVES OF TOXICOLOGY 89:541-554(2015).
    Lan, HN; Jiang, HL; et al. Development and Characterization of a Novel Anti-idiotypic Monoclonal Antibody to Growth Hormone, Which Can Mimic Physiological Functions of Growth Hormone in Primary Porcine Hepatocytes. ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES 28:573-583(2015).

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