JAK2

  • Official Full Name

    JAK2 Janus kinase 2

  • Synonyms

    JAK2; Janus kinase 2; tyrosine-protein kinase JAK2; JTK10; JAK-2; Janus kinase 2 (a protein tyrosine kinase); THCYT3;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human cells
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • DYKDDDDK
  • EPOR: N
  • terminal His
  • tag JAK2: N
  • terminal FLAG
  • tag
  • Flag
  • FLAG
  • Avi
  • GST
  • GST|His
  • His
  • His (Fc)
  • His|MBP
  • JAK2: N
  • tag EPOR: N
  • Myc
  • DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human JAK2-336H Active Recombinant Human JAK2 protein, GST-tagged Insect Cell GST
Human JAK2-81H Active Recombinant Human JAK2, GST-tagged Sf9 Insect Cell GST
Human JAK2-157H Recombinant Human JAK2 protein, His/MBP-tagged E.coli His/MBP 1053-1132 aa
Human JAK2-532H Recombinant Human Janus Kinase 2, His-tagged Sf9 Insect Cell His
Human JAK2-27628TH Recombinant Human JAK2, His-tagged His
Human JAK2-27629TH Recombinant Human JAK2, His-tagged His
Human JAK2-158H Recombinant Human JAK2 protein, His/MBP-tagged E.coli His/MBP 121-361 aa
Human JAK2-57H Recombinant Human JAK2 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human JAK2-2487H Recombinant human Jak2, His-tagged E.coli His
Human JAK2-5441H Recombinant Human Janus Kinase 2, GST-His-tagged Sf9 Insect Cell GST/His
Human JAK2-28H Recombinant Human JAK2 Protein, FLAG/Avi-tagged, Biotin-labeled HEK293 FLAG/Avi 1-1132
Human JAK2-26H Recombinant Human JAK2 (W659A, W777A, F794H) (JH2 Domain) Protein, His/Avi-tagged, Biotin-labeled Insect Cell His/Avi 536-812
Human JAK2-5439H Recombinant Human Janus Kinase 2, GST-tagged Insect Cell GST
Human JAK2-598H Recombinant Human JAK2 protein, His-tagged E.coli His Asn508~Ala800
Human JAK2-250H Recombinant Human JAK2 Mammalian Cell His
Human JAK2-1420H Active Recombinant Human AMPX Protein, His-tagged Insect Cell His
Human JAK2-01H Recombinant Human JAK2 Protein, His-tagged E. coli His
Human JAK2-254H Recombinant Human JAK2 Protein, His-tagged E.coli His Asn508~Ala800
Human JAK2-3372H Recombinant Human JAK2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human JAK2-3128H Recombinant Human JAK2 protein, His-tagged E.coli His 752-1132aa
Human JAK2-151H Recombinant Human JAK2 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human JAK2-27H Recombinant Human JAK2 (V617F) Protein, FLAG/Avi-tagged, Biotin-labeled HEK293 FLAG/Avi 1-1132
Human JAK2-29H Recombinant Human JAK2 (JH1, JH2 domain) Protein, GST/Avi-tagged, Biotin-labeled HEK293 GST/Avi 513-1132
Human JAK2-33H Recombinant Human JAK2 (JH2 Domain) (W659A, W777A,F794H) Protein, His-tagged Insect Cell His 536-812
Human JAK2-22H Recombinant Human JAK2 (JH1, JH2 domain) Protein, His/GST-tagged Insect Cell His/GST 532-1132
Human JAK2-30H Recombinant Human JAK2 (V617F) (JH2 Domain) Protein, His/Avi-tagged, Biotin-labeled Insect Cell His/Avi 513-827
Human JAK2-31H Recombinant Human JAK2 (V617F) (JH1, JH2 Domain) Protein, GST/Avi-tagged HEK293 GST/Avi 513-1132
Human JAK2-34H Recombinant Human JAK2 (V617F, W659A, W777A, F794H) Mutation Protein, His-tagged Insect Cell His 536-812
Human JAK2-23H Active Recombinant Human JAK2 (JH1 domain) Protein, His-tagged Insect Cell His 808-1132
Human JAK2-32H Recombinant Human JAK2 (JH2 Domain) (E596A, V617F, W659A, W777A, F794H) Protein, His-tagged Insect Cell His 535-812
Human JAK2-36H Recombinant Human EPOR and JAK2 Fusion Protein, His/FLAG-tagged Insect Cell EPOR: N-terminal His-tag JAK2: N-terminal FLAG-tag EPOR: 273-338, JAK2: 36-1132(end)
Human JAK2-37H Recombinant Human JAK2 (V617F, W659A, W777A, F794H) Mutation Protein, His/Avi-Tag, Biotin-Labeled Insect Cell His/Avi 536-812
Human JAK2-24H Recombinant Human JAK2 (V617F) (JH1, JH2 Domain) Protein, GST/Avi-tagged, Biotin-labeled HEK293 GST/Avi 513-1132
Human JAK2-3184H-B Recombinant Human JAK2 Protein Pre-coupled Magnetic Beads HEK293
Human JAK2-3184H Recombinant Human JAK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human JAK2-35H Recombinant Human JAK2 and EPOR Fusion Protein, FLAG/His-tagged Insect Cell JAK2: N-terminal FLAG-tag EPOR: N-terminal His-tag JAK2: 26-1132(end), EPOR: 273-338
Human JAK2-25H Recombinant Human JAK2 (JH2 Domain) Protein, His/Avi-tagged, Biotin-labeled Insect Cell His/Avi 513-827
Human JAK2-177HFL Recombinant Full Length Human JAK2 Protein, C-Flag-tagged Mammalian cells Flag
Mouse Jak2-3627M Recombinant Mouse Jak2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Jak2-255M Recombinant Mouse Jak2 Protein, His-tagged E.coli His Phe120~Ser367
Rat JAK2-3136R Recombinant Rat JAK2 Protein Mammalian Cell His
Rat JAK2-2792R Recombinant Rat JAK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Jak2-257R Recombinant Rat Jak2 Protein, His-tagged E.coli His Thr689~Ser807
Rat JAK2-2792R-B Recombinant Rat JAK2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque JAK2-2327R Recombinant Rhesus monkey JAK2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque JAK2-2148R Recombinant Rhesus Macaque JAK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque JAK2-2148R-B Recombinant Rhesus Macaque JAK2 Protein Pre-coupled Magnetic Beads HEK293
Chicken JAK2-2252C Recombinant Chicken JAK2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • JAK2 Related Articles
  • JAK2 Related Gene Family
  • JAK2 Related Research Area
  • JAK2 Related Signal Pathway

JAK2 involved in several pathways and played different roles in them. We selected most pathways JAK2 participated on our site, such as AGE/RAGE pathway, ARMS-mediated activation, Adipocytokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with JAK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AGE/RAGE pathwayDIAPH1;AGER;TIRAP;MMP13;EGFR;JUN;MAPK14;ATF2;CHUK
ARMS-mediated activationPAQR3A;PEA15;DUSP1;NEFLB;FGF10B;KBTBD7;JAK3;CSF2RB;CSF2RA
Adipocytokine signaling pathwayPCK1;TRAF2;ACACB;PRKAB1B;NFKBIB;RXRG;IRS2;MAPK8B;SOCS3
Axon guidanceSEMA3E;FRS2B;SEMA6C;LOC608458;RND1;RHOB;CLTC;SDCBP;GFRA4
BDNF signaling pathwayEIF4E;JAK2;CDKL5;CSNK2A1P;FRS3;CNR1;DPYSL2;DOK5;CFL1
CXCR4-mediated signaling eventsCRK;PAG1;GNB2L1;GNA13;MAPKAP1;ARR3;DNM1;CFL1;CSK
Chemokine signaling pathwayRAC2;PXN;CCL19;RAP1A;STAT1;Ccl9;CCL27;XCL1;VAV1
Cholinergic synapseAKT2;FYN;ACHE;GNB1;GNG10;ITPR3;MAPK3;KCNQ1;KCNJ4

JAK2 has several biochemical functions, for example, ATP binding, SH2 domain binding, acetylcholine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by JAK2 itself. We selected most functions JAK2 had, and list some proteins which have the same functions with JAK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingKIF2A;TSSK6;CHD4;WEE2;CDK10;FGFR1;ZAP70;CAMK2D2;IARS2
SH2 domain bindingLILRB1;JAK2;SHCBP1;KHDRBS2;IRS1;INPPL1;SYNGR3;MS4A2;SKAP1
acetylcholine receptor bindingRAPSN;NRXN1;JAK2;DLG4;RER1;APP;UBXN2A;KCNS1;RIC3
growth hormone receptor bindingGH1;TYK2;SOCS2;JAK2;JAK1;Gh
heme bindingPTGS2B;NGB;CYP2AA1;BA1;CYP2AA7;CYP20A1;HBE;CYP2J5;PGRMC1
histone bindingHIST1H3F;NFKBIL2;ASF1A;TBL1X;DTX3L;NAP1L2;ATAD2;SMARCA4A;PRKCB
histone kinase activity (H3-Y41 specific)
insulin receptor substrate bindingGRB2;INSR;PRKCD;IGF1RB;PIK3R1;PIK3CA;INSRR;PIK3CB;JAK2
interleukin-12 receptor bindingJAK2;IL12B;IL12BA;IL12A
non-membrane spanning protein tyrosine kinase activityPTK2B;SYK;PTK6;PTK2AA;TNK2;ZNF143B;CSK;STYK1;BTK
peptide hormone receptor bindingJAK2;RUNDC3A;PTPN11;NPPC;NPPA;LEP;ADCYAP1;PTHLHA;PTHLH
phosphatidylinositol 3-kinase bindingTYRO3;CALM3;CALM2;IGF1R;ATP1A1;IGF1RB;IRS2;INSRA;FYN
protein C-terminus bindingNCF2;TAX1BP3;ERCC2;NCL;SIRT1;SNX17;PEX10;DLG4;XRCC6
protein bindingNCALD;TUBA1B;SPON1;GOPC;CST5;MLLT10;RPUSD4;CPNE7;UACA
protein kinase activityTEX14;GRK1B;TSSK5;NRBP1;RBM4.3;DCLK1A;MAP3K11;ACVR1L;FASTKD1
protein kinase bindingRPTOR;IFNAR2;C10orf46;RPS6KA3;PPP1CB;CCNK;DVL1;RHEB;ARHGEF7
protein tyrosine kinase activityDYRK3;TESK1;TTN;ROS1;BCR;FGFR2;KDR;MUSK;RET
receptor bindingC5;GDNF;PANX1;PLAT;FGF6B;GUSB;FGF1B;CXCL10;CCL17
type 1 angiotensin receptor bindingGNG3;GNA13;ARRB2;BDKRB2;GNA13A;GNA13B;JAK2;GNB1;TYK2

JAK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with JAK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of JAK2.

PTPN1; CSF2RB; MPL; SH2B1; saicar; EGFR; PKM

Rath, T; Billmeier, U; et al. From physiology to disease and targeted therapy: interleukin-6 in inflammation and inflammation-associated carcinogenesis. ARCHIVES OF TOXICOLOGY 89:541-554(2015).
Lan, HN; Jiang, HL; et al. Development and Characterization of a Novel Anti-idiotypic Monoclonal Antibody to Growth Hormone, Which Can Mimic Physiological Functions of Growth Hormone in Primary Porcine Hepatocytes. ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES 28:573-583(2015).
  • Q&As
  • Reviews

Q&As (7)

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What role does JAK2 play in myeloproliferative neoplasms (MPNs)? 11/17/2022

JAK2 mutations, particularly JAK2 V617F, are hallmarks of several MPNs, including polycythemia vera, essential thrombocythemia, and primary myelofibrosis. These mutations lead to uncontrolled cell proliferation.

How does JAK2 activation lead to downstream signal transduction? 02/26/2022

Upon cytokine binding to its receptor, JAK2 becomes activated through phosphorylation. This activation leads to the phosphorylation and activation of STAT (Signal Transducers and Activators of Transcription) proteins, which then translocate to the nucleus and regulate gene expression.

What is the primary function of the JAK2 protein in cellular signaling? 10/19/2021

JAK2 is a non-receptor tyrosine kinase that plays a pivotal role in cytokine signaling, mediating cellular responses to growth factors and various cytokines.

How is JAK2 involved in hematopoiesis and blood cell development? 04/21/2021

JAK2 is crucial for hematopoiesis, especially in the signaling pathways of erythropoietin and thrombopoietin, which are essential for red blood cell and platelet production, respectively.

How does JAK2 interact with cytokine receptors, and what is its significance? 10/29/2020

JAK2 associates with the intracellular domains of specific cytokine receptors. Upon cytokine binding, JAK2 becomes activated, leading to downstream signaling events. This interaction is vital for mediating cellular responses to various cytokines.

Are there therapeutic agents that target JAK2, and in what contexts are they used? 03/11/2019

Yes, there are several JAK2 inhibitors, such as ruxolitinib and fedratinib, which are used to treat MPNs. They work by inhibiting the kinase activity of JAK2, thereby reducing aberrant cell proliferation.

Are there known mutations in the JAK2 gene, and what are their implications? 02/06/2018

Yes, one of the most well-known mutations is JAK2 V617F, which results in constitutive activation of the kinase. This mutation is associated with various myeloproliferative neoplasms (MPNs).

Customer Reviews (3)

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Reviews
10/03/2020

    Quick response from customer service.

    05/12/2020

      Product performed as expected.

      08/07/2018

        Satisfied with product quality.

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