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Recombinant Human EPOR and JAK2 Fusion Protein, His/FLAG-tagged

Cat.No. : JAK2-36H
Product Overview : Complex of Human EPOR, also known as Erythropoietin receptor, GenBank Accession No. NM_000121, a.a. 273-338 with N-terminal His-tag, MW=9 kDa, and JAK2, also known as Janus Kinase 2, with V617F, Y1007F and Y1008F mutations, GenBank Accession No. NM_004972, a.a. 36-1132(end), with N-terminal FLAG-tag, MW=128 kDa. The proteins were expressed as single fusion protein with a (GSSG)6  linker in a Baculovirus infected Sf9 cell expression system.
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Source : Insect cell
Species : Human
Tag : EPOR: N-terminal His-tag
JAK2: N-terminal FLAG-tag
Form : Aqueous buffer solution
Molecular Mass : EPOR: 9 kDa, JAK2: 128 kDa
Protein length : EPOR: 273-338, JAK2: 36-1132(end)
Purity : 89%
Storage : At least 6 months at –80 centigrade.
Storage Buffer : 50 mM Tris-HCl, pH 8.0, 500 mM NaCl, 10% glycerol, 3 mM DTT.
Gene Name : JAK2 Janus kinase 2 [ Homo sapiens (human) ]
Official Symbol : JAK2
Synonyms : JAK2; Janus kinase 2; JTK10; tyrosine-protein kinase JAK2; JAK-2; Janus kinase 2 (a protein tyrosine kinase); EC 2.7.10.2; jak; jh1
Gene ID : 3717
mRNA Refseq : NM_004972
Protein Refseq : NP_004963
MIM : 147796
UniProt ID : O60674

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does JAK2 play in myeloproliferative neoplasms (MPNs)? 11/17/2022

JAK2 mutations, particularly JAK2 V617F, are hallmarks of several MPNs, including polycythemia vera, essential thrombocythemia, and primary myelofibrosis. These mutations lead to uncontrolled cell proliferation.

How does JAK2 activation lead to downstream signal transduction? 02/26/2022

Upon cytokine binding to its receptor, JAK2 becomes activated through phosphorylation. This activation leads to the phosphorylation and activation of STAT (Signal Transducers and Activators of Transcription) proteins, which then translocate to the nucleus and regulate gene expression.

What is the primary function of the JAK2 protein in cellular signaling? 10/19/2021

JAK2 is a non-receptor tyrosine kinase that plays a pivotal role in cytokine signaling, mediating cellular responses to growth factors and various cytokines.

How is JAK2 involved in hematopoiesis and blood cell development? 04/21/2021

JAK2 is crucial for hematopoiesis, especially in the signaling pathways of erythropoietin and thrombopoietin, which are essential for red blood cell and platelet production, respectively.

How does JAK2 interact with cytokine receptors, and what is its significance? 10/29/2020

JAK2 associates with the intracellular domains of specific cytokine receptors. Upon cytokine binding, JAK2 becomes activated, leading to downstream signaling events. This interaction is vital for mediating cellular responses to various cytokines.

Are there therapeutic agents that target JAK2, and in what contexts are they used? 03/11/2019

Yes, there are several JAK2 inhibitors, such as ruxolitinib and fedratinib, which are used to treat MPNs. They work by inhibiting the kinase activity of JAK2, thereby reducing aberrant cell proliferation.

Are there known mutations in the JAK2 gene, and what are their implications? 02/06/2018

Yes, one of the most well-known mutations is JAK2 V617F, which results in constitutive activation of the kinase. This mutation is associated with various myeloproliferative neoplasms (MPNs).

Customer Reviews (3)

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Reviews
10/03/2020

    Quick response from customer service.

    05/12/2020

      Product performed as expected.

      08/07/2018

        Satisfied with product quality.

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