Recombinant Mouse MMP-2/TIMP-2 Complex

Cat.No. : Mmp2-44M
Product Overview : Matrix Metalloproteinase 2 - TIMP-2 Complex (MMP-2, Gelatinase A, 72 kDa Type IV Collagenase, EC 3.4.24.24) from mouse fibroblasts.
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Source : Mouse fibroblasts
Species : Mouse
Form : Liquid, in 50 mM Tris/HCl, pH 7.0, 200 mM NaCl, 5 mM CaCl2, 1 μM ZnCl2, 0.05% NaN3, 0.05% Brij 35
Purity : >95%, homogenous by electrophoresis and Western Blotting analysis
Storage : if stored at -70°C. The enzyme can be kept at -20°C for several weeks without significant loss of activity. Repeated freezing and thawing must be avoided. Do always keep the enzyme on ice. If kept at room temperature for hours without substrate the enzyme looses significant activity!
Gene Name : Mmp2 matrix metallopeptidase 2 [ Mus musculus ]
Official Symbol : Mmp2
Synonyms : MMP2; matrix metallopeptidase 2; 72 kDa type IV collagenase; gelatinase A; 72kD gelatinase; 72kDa gelatinase; 72 kDa gelatinase; 72kD type IV collagenase; 72kDa type IV collagenase; matrix metalloproteinase 2; matrix metalloproteinase-2; GelA; Clg4a; MMP-2;
Gene ID : 17390
mRNA Refseq : NM_008610
Protein Refseq : NP_032636
Pathway : Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; GnRH signaling pathway, organism-specific biosystem; GnRH signaling pathway, conserved biosystem; IL-3 Signaling Pathway, organism-specific biosystem;
Function : fibronectin binding; hydrolase activity; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How to regulate the activity of MMP2 in tumor therapy? 10/20/2022

The activity of MMP2 is regulated by inhibitors and antibodies against it to inhibit tumor metastasis and invasion.

How is MMP2 related to metastases that promote disease progression? 05/04/2022

MMP2 interacts with some transfer factors, such as VEGF and EGF, to promote tumor metastasis and invasion.

What are the application prospects of MMP2 inhibitors? 02/20/2022

Inhibitors of MMP2 can be used as potential drug targets for the treatment of tumors, cardiovascular diseases and other related diseases.

Does MMP2 interact with the tumor microenvironment? 09/15/2021

MMP2 interacts with tumor cells, immune cells, blood vessels, etc. in the tumor microenvironment to affect tumor progression and treatment effect.

What is the role of MMP2 in embryonic development? 10/18/2020

It is involved in important processes such as morphogenesis, organ development and intraembryonic lymphatic vessel formation during embryonic development.

What are the effects of MMP2 mutations in human disease? 10/13/2020

Mutations in MMP2 may affect its protein structure and function, leading to the occurrence and progression of related diseases.

Customer Reviews (3)

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06/19/2021

    The solubility and ion exchange ability are very good, which is convenient for subsequent experimental treatment and purification.

    05/13/2021

      Kinetic parameters such as enzymatic reaction rate and binding affinity were tested in the early stage, and it was found that the protein performed well.

      03/16/2021

        MMP2 products undergo strict quality control to ensure the consistency and stability of each batch.

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