Recombinant Human MMP2

Cat.No. : MMP2-169H
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Cat. No. : MMP2-169H
Overview : Recombinant Human MMP-2 (catalytic domain) was expressed in yeast and used for Studying enzyme kinetics, cleaving target substrates, and screening for inhibitors.
Description : Active recombinant matrix metalloproteinase-2 (MMP-2, gelatinase A, 72kDa type IV collagenase) cloned from human cDNA. The enzyme consists of residues Tyr110-Asp452 (NM_004530), which comprises the catalytic/fibronectin domain of human MMP-2, with a C-terminal purification tag. This represents a naturally occurring active form of MMP-2 which lacks the C-terminal hemopexin domain. MMPs lacking this domain cannot cleave native collagens; however, activity toward other targets such as gelatin, casein, or peptide substrates is unaffected.
Source : yeast
Species : Human
Predicted MolecularMass : 40 kDa
Purity : >95% by SDS-PAGE.
Long Term Storage : -80°C
Note : When stored under the above conditions, this enzyme is stable at the concentration supplied, in its current storage buffer. Procedures such as dilution of the enzyme followed by refreezing could lead to loss of activity.
OfficialSymbol : MMP2
Gene Name : MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) [ Homo sapiens ]
Synonyms : MMP 2; Matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); 72 kDa gelatinase; 72kD type IV collagenase; CLG 4; CLG 4A; CLG4; CLG4A; Collagenase Type 4 alpha; Collagenase type IV A; Gelatinase A; Gelatinase alpha; Gelatinase neutrophil; Matrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenase; Matrix Metalloproteinase 2; Matrix metalloproteinase II; Matrix metalloproteinase-2; MMP II; MMP-2; MMP2; MONA; Neutrophil gelatinase; PEX; TBE 1; TBE-1; MMP-II; collagenase type IV-A; matrix metalloproteinase-II; EC 3.4.24.24; EC 3.4.24
Gene ID : 4313
mRNA Refseq : NM_004530
Protein Refseq : NP_004521
MIM : 120360
UniProt ID : P08253
Chromosome Location : 16q13-q21
Pathway : ATF-2 transcription factor network; Angiopoietin receptor Tie2-mediated signaling; Bladder cancer; Diabetes pathways; Disease; GnRH signaling pathway; LPA receptor mediated events; Osteopontin-mediated events; amb2 Integrin signaling; Syndecan-2-mediated signaling events
Function : metalloendopeptidase activity; serine-type endopeptidase activity; zinc ion binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How to regulate the activity of MMP2 in tumor therapy? 10/20/2022

The activity of MMP2 is regulated by inhibitors and antibodies against it to inhibit tumor metastasis and invasion.

How is MMP2 related to metastases that promote disease progression? 05/04/2022

MMP2 interacts with some transfer factors, such as VEGF and EGF, to promote tumor metastasis and invasion.

What are the application prospects of MMP2 inhibitors? 02/20/2022

Inhibitors of MMP2 can be used as potential drug targets for the treatment of tumors, cardiovascular diseases and other related diseases.

Does MMP2 interact with the tumor microenvironment? 09/15/2021

MMP2 interacts with tumor cells, immune cells, blood vessels, etc. in the tumor microenvironment to affect tumor progression and treatment effect.

What is the role of MMP2 in embryonic development? 10/18/2020

It is involved in important processes such as morphogenesis, organ development and intraembryonic lymphatic vessel formation during embryonic development.

What are the effects of MMP2 mutations in human disease? 10/13/2020

Mutations in MMP2 may affect its protein structure and function, leading to the occurrence and progression of related diseases.

Customer Reviews (3)

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06/19/2021

    The solubility and ion exchange ability are very good, which is convenient for subsequent experimental treatment and purification.

    05/13/2021

      Kinetic parameters such as enzymatic reaction rate and binding affinity were tested in the early stage, and it was found that the protein performed well.

      03/16/2021

        MMP2 products undergo strict quality control to ensure the consistency and stability of each batch.

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