Recombinant Mouse Mmp2 Protein, His-tagged
Cat.No. : | Mmp2-1784M |
Product Overview : | Recombinant Mouse Mmp2 Protein (Tyr445-Cys662) with N-His tag was expressed in E. coli. |
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Description : | This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that hydrolyzes collagens, gelatins, laminin, fibronectin and elastin. Mice lacking the encoded protein exhibit suppressed angiogenesis and attenuated features of human multicentric osteolysis with arthritis including abnormal skeletal and craniofacial development. |
Source : | E. coli |
Species : | Mouse |
Tag : | His |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 25.8 kDa Accurate Molecular Mass: 27 kDa |
Protein length : | Tyr445-Cys662 |
Purity : | > 97% |
Applications : | Positive Control; Immunogen; SDS-PAGE; WB. |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months. |
Storage Buffer : | 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300. |
Reconstitution : | Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex. |
Gene Name : | Mmp2 matrix metallopeptidase 2 [ Mus musculus (house mouse) ] |
Official Symbol : | Mmp2 |
Synonyms : | MMP2; matrix metallopeptidase 2; 72 kDa type IV collagenase; gelatinase A; 72kD gelatinase; 72kDa gelatinase; 72 kDa gelatinase; 72kD type IV collagenase; 72kDa type IV collagenase; matrix metalloproteinase 2; matrix metalloproteinase-2; GelA; Clg4a; MMP-2; |
Gene ID : | 17390 |
mRNA Refseq : | NM_008610 |
Protein Refseq : | NP_032636 |
UniProt ID : | P33434 |
Products Types
◆ Recombinant Protein | ||
Mmp2-10593M | Recombinant Mouse Mmp2 Protein, His (Fc)-Avi-tagged | +Inquiry |
MMP2-657R | Recombinant Rat MMP2 Protein (110-662 aa), His-SUMO-tagged | +Inquiry |
Mmp2-1786R | Recombinant Rat Mmp2 Protein, His-tagged | +Inquiry |
Mmp2-1783M | Recombinant Mouse Mmp2 Protein, His-tagged | +Inquiry |
MMP2-562H | Recombinant Human MMP2 Protein, MYC/DDK-tagged | +Inquiry |
◆ Native Protein | ||
MMP2-46H | Native Human MMP-2 | +Inquiry |
MMP2-29475TH | Native Human MMP2 | +Inquiry |
MMP2-8455M | Native Mouse MMP2 | +Inquiry |
◆ Lysates | ||
MMP2-2380HCL | Recombinant Human MMP2 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0320C | MMP2 Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
Not For Human Consumption!
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Customer Reviews (3)
Write a reviewThe solubility and ion exchange ability are very good, which is convenient for subsequent experimental treatment and purification.
Kinetic parameters such as enzymatic reaction rate and binding affinity were tested in the early stage, and it was found that the protein performed well.
MMP2 products undergo strict quality control to ensure the consistency and stability of each batch.
Q&As (6)
Ask a questionThe activity of MMP2 is regulated by inhibitors and antibodies against it to inhibit tumor metastasis and invasion.
MMP2 interacts with some transfer factors, such as VEGF and EGF, to promote tumor metastasis and invasion.
Inhibitors of MMP2 can be used as potential drug targets for the treatment of tumors, cardiovascular diseases and other related diseases.
MMP2 interacts with tumor cells, immune cells, blood vessels, etc. in the tumor microenvironment to affect tumor progression and treatment effect.
It is involved in important processes such as morphogenesis, organ development and intraembryonic lymphatic vessel formation during embryonic development.
Mutations in MMP2 may affect its protein structure and function, leading to the occurrence and progression of related diseases.
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