Recombinant Rat MMP2 Protein (110-662 aa), His-SUMO-tagged
Cat.No. : | MMP2-657R |
Product Overview : | Recombinant Rat MMP2 Protein (110-662 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Protein Description: Full Length of Mature Protein. |
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- Gene Information
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Description : | Ubiquitinous metalloproteinase that is involved in diverse functions such as rodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading Extracellular domain matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues .PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrin alpha-v/beta3 on the surface of blood vessels. |
Source : | E. coli |
Species : | Rat |
Tag : | His-SUMO |
Form : | Tris-based buffer, 50% glycerol |
Molecular Mass : | 78.1 kDa |
Protein length : | 110-662 aa |
AA Sequence : | YNFFPRKPKWDKNQITYRIIGYTPD LDPETVDDAFARALKVWSDVTPLRF SRIHDGEADIMINFGRWEHGDGYPF DGKDGLLAHAFAPGTGVGGDSHFDD DELWTLGEGQVVRVKYGNADGEYCK FPFLFNGREYSSCTDTGRSDGFLWC STTYNFEKDGKYGFCPHEALFTMGG NGDGQPCKFPFRFQGTSYNSCTTEG RTDGYRWCGTTEDYDRDKKYGFCPE TAMSTVGGNSEGAPCVFPFTFLGNK YESCTSAGRSDGKVWCATTTNYDDD RKWGFCPDQGYSLFLVAAHEFGHAM GLEHSQDPGALMAPIYTYTKNFRLS NDDIKGIQELYGPSPDADTDTGTGP TPTLGPVTPEICKQDIVFDGIAQIR GEIFFFKDRFIWRTVTPRDKPTGPL LVATFWPELPEKIDAVYEAPQEEKA VFFAGNEYWVYSASTLERGYPKPLT SLGLPPDVQQVDAAFNWSKNKKTYI FSGDKFWRYNEVKKKMDPGFPKLIA DSWNAIPDNLDAVVDLQGGGHSYFF KGAYYLKLENQSLKSVKFGSIKSDW LGC |
Purity : | > 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Concentration : | A hardcopy of COA with concentration instruction is sent along with the products. |
Gene Name : | Mmp2 matrix metallopeptidase 2 [ Rattus norvegicus ] |
Official Symbol : | MMP2 |
Synonyms : | MMP2; MMP-2; gelatinase A; 72 kDa gelatinase; |
Gene ID : | 81686 |
mRNA Refseq : | NM_031054 |
Protein Refseq : | NP_112316 |
UniProt ID : | P33436 |
Products Types
◆ Recombinant Protein | ||
Mmp2-1784M | Recombinant Mouse Mmp2 Protein, His-tagged | +Inquiry |
MMP2-220H | Active Recombinant Human MMP2 Protein (Tyr120-Cys660), C-His tagged, Animal-free, Carrier-free | +Inquiry |
MMP2-1122C | Recombinant Chicken MMP2 Protein, His-tagged | +Inquiry |
Mmp2-44M | Recombinant Mouse MMP-2/TIMP-2 Complex | +Inquiry |
MMP2-562H | Recombinant Human MMP2 Protein, MYC/DDK-tagged | +Inquiry |
◆ Native Protein | ||
MMP2-46H | Native Human MMP-2 | +Inquiry |
MMP2-47H | Native Human MMP-2/TIMP-2 Complex | +Inquiry |
MMP2-29475TH | Native Human MMP2 | +Inquiry |
◆ Lysates | ||
MMP2-2380HCL | Recombinant Human MMP2 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0320C | MMP2 Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThe activity of MMP2 is regulated by inhibitors and antibodies against it to inhibit tumor metastasis and invasion.
MMP2 interacts with some transfer factors, such as VEGF and EGF, to promote tumor metastasis and invasion.
Inhibitors of MMP2 can be used as potential drug targets for the treatment of tumors, cardiovascular diseases and other related diseases.
MMP2 interacts with tumor cells, immune cells, blood vessels, etc. in the tumor microenvironment to affect tumor progression and treatment effect.
It is involved in important processes such as morphogenesis, organ development and intraembryonic lymphatic vessel formation during embryonic development.
Mutations in MMP2 may affect its protein structure and function, leading to the occurrence and progression of related diseases.
Customer Reviews (3)
Write a reviewThe solubility and ion exchange ability are very good, which is convenient for subsequent experimental treatment and purification.
Kinetic parameters such as enzymatic reaction rate and binding affinity were tested in the early stage, and it was found that the protein performed well.
MMP2 products undergo strict quality control to ensure the consistency and stability of each batch.
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