Active Recombinant Human Tumor Necrosis Factor

• Cat.No.: TGFA-7H
• Product Overview: Human TNF- alpha (Cachectin) is produced in genetically engineered yeast, and purified by sequential chromatography.

Specification

• Description: Human Tumor necrosis factor (TNF- alpha), also known as Cachectin, is a cytokine composed of 157 amino acid residues, having a molecular weight of 17 kDa (monomer). There is 79% homology between human and murine TNF- alpha, including conserved cysteine residues which form an intrachain disulfide bridge. Biological effects of this cytokine include antitumor activity in vivo and in vitro, activation of polymorphonuclear leukocytes, antiviral activity, and the induction of the release if Interleukin-1 or colony stimulating factors from a variety of sources.
• Source: yeast
• Species: Human
• Form: At concentration of 1 mg/ml in 0.02M Tris-HCl/ 0.15 M NaCl (pH 8.0)
• Bio-activity: The cell cytolytic activity is determined in the L929 cells (3 x 104 cells/assay) and it is 2-4 x 108 U/mg.
• Molecular Mass: 17 KDa
• Purity: Over 95% pure by SDS gel electrophoresis.
• Stability: At least 1 year at -80°C.
• Storage: Store at -80°C.
• Tag: Non

Gene Information

• Gene Name: TGFA?transforming growth factor, alpha [?Homo sapiens?(human) ]
• Official Symbol: TGFA
• Synonyms: TGFA; transforming growth factor, alpha; TFGA; protransforming growth factor alpha; transforming growth factor-alpha; TGF-alpha; EGF-like TGF; TGF type 1; ETGF
• Gene ID: 7039
• mRNA Refseq: NM_001099691
• Protein Refseq: NP_001093161
• MIM: 190170
• UniProt ID: P01135
• Chromosome Location: 2p13
• Pathway: ErbB signaling pathway; Glioma; Non-small cell lung cancer; Pancreatic cancer; Pathways in cancer; Prostate cancer; Renal cell carcinoma
• Function: MAP kinase kinase activity; epidermal growth factor receptor binding; growth factor activity; protein binding; signal transducer activity

Reviews

05/03/2020

Swift and accurate service, essential for research success.

04/14/2020

Invaluable support for insights, a research cornerstone.

12/21/2018

Trustworthy results, supports research consistency.

Q&As

How does TGFA contribute to cell growth and proliferation?

It stimulates cell proliferation and survival, playing a key role in tissue development.

How do genetic variations in TGFA affect tissue repair?

Genetic mutations in TGFA can lead to impaired wound healing and tissue regeneration.

What is the impact of altered TGFA activity on cancer development?

Altered TGFA activity is linked with cancer progression, as it can stimulate uncontrolled cell growth.

What is the primary role of TGFA in cell signaling?

TGFA, a growth factor, is vital for activating signaling pathways that control cell growth and differentiation.

What potential therapeutic applications arise from targeting TGFA in regenerative medicine and oncology?

Targeting TGFA offers potential for treating wounds and cancer by modulating growth factor signaling.

How does TGFA interact with other growth factors and receptors?

TGFA interacts with epidermal growth factor receptors, influencing various cellular processes.

What role does TGFA play in wound healing?

TGFA is important in wound healing, promoting the regeneration of skin and other tissues.