Recombinant Human Transforming Growth Factor, Alpha

• Cat.No.: TGFA-5521H
• Product Overview: Recombinant Human TGFAcomprises the human TGF-alpha amino acid sequence plus a 14 amino acidN-terminal extension peptide.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: This product is alow cost, potent analog of human TGF-alpha. The recombinant growth factor canbe used as a supplement for serum-free or low serum cell culture. It is alsosuitable for cultured fibroblasts, particularly from avian species used inthe production of viral vaccines.
• Form: Lyophilized whitepowder. Dried from 0.1 M acetic acid and stored under nitrogen at a slightvacuum.
• Purity: > 90% (byN-terminal sequence analysis).
• Molecular Weight: 7113Daltons-confirmed by Mass Spectrometry (minor N-terminal formylated form of7142 Daltons).
• N-terminal SequenceAnalysis: 18 residues > 96% single sequence.
• Biological Activity: Cell proliferationin Balb/c 3T3 fibroblasts: ED50 <20 ng/ml (in the presence of100 ng/ml Long TMR3IGF-I).
• Endotoxin: < 0.1 EU/μg
• Reconstitution: Handling of GroPepLONG™EGF and LONG™TGF-α.
• Storage: At least 2 years at2 - 4°C (lyophilized).
• OfficialSymbol: TGFA
• Pathways: Direct p53effectors; ErbB receptor signaling network; ErbB signaling pathway; FOXM1transcription factor network; Glioma; Non-small cell lung cancer; Pancreaticcancer; Pathways in cancer; Prostate cancer; Renal cell carcinoma

Gene Information

• Gene Name: TGFA transforming growth factor,alpha [ Homo sapiens ]
• Synonyms: TGFA; transforminggrowth factor, alpha; TFGA; protransforming growth factor alpha;TGF-alpha; OTTHUMP00000160075; OTTHUMP00000203300; OTTHUMP00000203301;OTTHUMP00000203345; OTTHUMP00000203352; OTTHUMP00000225517; Protransforming growth factor alpha;Transforming growth factor alpha
• Gene ID: 7039
• mRNA Refseq: NM_001099691
• Protein Refseq: NP_001093161
• MIM: 190170
• UniProt ID: P01135
• Chromosome Location: 2p13
• Function: MAP kinase kinaseactivity; epidermal growth factor receptor binding; glycoprotein binding;growth factor activity; protein binding; signal transducer activity