Recombinant Human Transforming Growth Factor, Alpha

• Cat.No.: TGFA-5521H
• Product Overview: Recombinant Human TGFAcomprises the human TGF-alpha amino acid sequence plus a 14 amino acidN-terminal extension peptide.

Specification

• Cat. No.: TGFA-5521H
• Description: This product is alow cost, potent analog of human TGF-alpha. The recombinant growth factor canbe used as a supplement for serum-free or low serum cell culture. It is alsosuitable for cultured fibroblasts, particularly from avian species used inthe production of viral vaccines.
• Source: E. coli
• Species: Human
• Form: Lyophilized whitepowder. Dried from 0.1 M acetic acid and stored under nitrogen at a slightvacuum.
• Purity: > 90% (byN-terminal sequence analysis).
• Molecular Weight: 7113Daltons-confirmed by Mass Spectrometry (minor N-terminal formylated form of7142 Daltons).
• N-terminal SequenceAnalysis: 18 residues > 96% single sequence.
• Biological Activity: Cell proliferationin Balb/c 3T3 fibroblasts: ED50 <20 ng/ml (in the presence of100 ng/ml Long TMR3IGF-I).
• Endotoxin: < 0.1 EU/μg
• Reconstitution: Handling of GroPepLONG™EGF and LONG™TGF-α.
• Storage: At least 2 years at2 - 4°C (lyophilized).
• OfficialSymbol: TGFA
• Pathways: Direct p53effectors; ErbB receptor signaling network; ErbB signaling pathway; FOXM1transcription factor network; Glioma; Non-small cell lung cancer; Pancreaticcancer; Pathways in cancer; Prostate cancer; Renal cell carcinoma
• Tag: Non

Gene Information

• Gene Name: TGFA transforming growth factor,alpha [ Homo sapiens ]
• Synonyms: TGFA; transforminggrowth factor, alpha; TFGA; protransforming growth factor alpha;TGF-alpha; OTTHUMP00000160075; OTTHUMP00000203300; OTTHUMP00000203301;OTTHUMP00000203345; OTTHUMP00000203352; OTTHUMP00000225517; Protransforming growth factor alpha;Transforming growth factor alpha
• Gene ID: 7039
• mRNA Refseq: NM_001099691
• Protein Refseq: NP_001093161
• MIM: 190170
• UniProt ID: P01135
• Chromosome Location: 2p13
• Function: MAP kinase kinaseactivity; epidermal growth factor receptor binding; glycoprotein binding;growth factor activity; protein binding; signal transducer activity

Reviews

05/03/2020

Swift and accurate service, essential for research success.

04/14/2020

Invaluable support for insights, a research cornerstone.

12/21/2018

Trustworthy results, supports research consistency.

Q&As

How does TGFA contribute to cell growth and proliferation?

It stimulates cell proliferation and survival, playing a key role in tissue development.

How do genetic variations in TGFA affect tissue repair?

Genetic mutations in TGFA can lead to impaired wound healing and tissue regeneration.

What is the impact of altered TGFA activity on cancer development?

Altered TGFA activity is linked with cancer progression, as it can stimulate uncontrolled cell growth.

What is the primary role of TGFA in cell signaling?

TGFA, a growth factor, is vital for activating signaling pathways that control cell growth and differentiation.

What potential therapeutic applications arise from targeting TGFA in regenerative medicine and oncology?

Targeting TGFA offers potential for treating wounds and cancer by modulating growth factor signaling.

How does TGFA interact with other growth factors and receptors?

TGFA interacts with epidermal growth factor receptors, influencing various cellular processes.

What role does TGFA play in wound healing?

TGFA is important in wound healing, promoting the regeneration of skin and other tissues.