Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 9, His-tagged

• Cat.No.: TNFRSF9-5598H
• Product Overview: Recombinant humanTNFRSF9 protein, fused to His-tag at N-terminus, was expressed in E.coli andpurified by using conventional chromatography techniques.

Specification

• Cat. No.: TNFRSF9-5598H
• Description: TNFRSF9, also knownas CD137 or ILA, is a member of the TNF superfamily of receptors. Thisprotein is mainly expressed on the surface of a variety of T cells, but alsofound in B cells, monocytes, and various transformed cell lines. TNFRSF9 isexpressed on activated T cells and binds an inducible ligand that is found onB cells, macrophages and dendritic cells.
• Source: E. coli
• Species: Human
• Form: Liquid. In 20mMTris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol,1mM DTT.
• Molecular Weight: 20 kDa (193aa),confirmed by MALDI-TOF.
• Purity: > 90% by SDS - PAGE.
• Concentration: 0.5 mg/ml(determined by Bradford assay).
• Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MGSMFERTRS LQDPCSNCPA GTFCDNNRNQ ICSPCPPNSF SSAGGQRTCD ICRQCKGVFRTRKECSSTSN AECDCTPGFH CLGAGCSMCE QDCKQGQELT KKGCKDCCFG TFNDQKRGIC RPWTNCSLDGKSVLVNGTKE RDVVCGPSPA DLSPGASSVT PPAPAREPGH SPQ
• Storage: Can be stored at+4°C short term (1-2 weeks). For long term storage, aliquot and store at-20°C or -70°C. Avoid repeated freezing and thawing cycles.
• OfficialSymbol: TNFRSF9

Gene Information

• Gene Name: TNFRSF9 tumor necrosis factorreceptor superfamily, member 9 [ Homo sapiens ]
• Synonyms: TNFRSF9; tumornecrosis factor receptor superfamily, member 9; ILA; 4-1BB; CD137;CDw137;tumor necrosis factor receptor superfamily member 9; CD137 antigen; Tcell antigen ILA; T-cell antigen ILA; 4-1BB ligand receptor; homolog of mouse4-1BB; receptor protein 4-1BB; T-cell antigen 4-1BB homolog; induced bylymphocyte activation (ILA); interleukin-activated receptor, homolog of mouseLy63
• Gene ID: 3604
• mRNA Refseq: NM_001561
• Protein Refseq: NP_001552
• MIM: 602250
• UniProt ID: Q07011
• Chromosome Location: 1p36
• Pathway: Cytokine-cytokinereceptor interaction; Downstream signaling in naive CD8+ T cells
• Function: binding; receptoractivity

Reviews

03/11/2022

Good heat resistance, long time treatment at high temperature, still has activity.

10/11/2021

The results obtained by SDS-PAGE or Western blot analysis were good.

07/30/2021

The purity is good, and the experimental results obtained are accurate.

Q&As

What diseases are associated with abnormal expression levels of TNFRSF9?

Studies have found that abnormal expression levels of TNFRSF9 may be associated with certain tumors, autoimmune diseases, and inflammatory diseases.

What is the association of TNFRSF9 with other cytokines?

It has a variety of associations with other proteins and cytokines. For example, it may interact with the NF-kB signaling pathway to regulate the inflammatory response, and it may also interact with apoptosis-related proteins to regulate the apoptosis process.

What are the main functions of TNFRSF9 in the human body?

TNFRSF9 mainly plays an important role in the immune system, as an activating signaling molecule, it is able to stimulate the activation, proliferation and survival of T cells and NK cells.

Are there potential therapeutic applications for TNFRSF9 inhibitors or activators?

Inhibitors or activators targeting TNFRSF9 may have potential applications for the treatment of certain tumors, autoimmune diseases, and inflammatory diseases.

How does TNFRSF9 bind to its ligands?

The extracellular domain of TNFRSF9 can bind to its ligand, such as 4-1BBL, to initiate signal transduction, which in turn activates downstream signaling pathways.

How is TNFRSF9 related to immuno-oncology?

TNFRSF9 has some potential in tumor immunotherapy. Several antibody drugs have been developed to use the stimulating effects of TNFRSF9 to enhance the activity of immune cells to fight tumors.