Recombinant Mouse Tnfrsf9 Protein, His-tagged

• Cat.No.: Tnfrsf9-453M
• Product Overview: Recombinant Mouse Tnfrsf9 Protein (Val24-Pro179) with N-His tag was expressed in E. coli.

Specification

• Description: Enables cytokine binding activity; identical protein binding activity; and signaling receptor activity. Acts upstream of or within negative regulation of interleukin-10 production; negative regulation of interleukin-12 production; and regulation of cell population proliferation. Located in external side of plasma membrane and extracellular space. Is expressed in renal vasculature. Orthologous to human TNFRSF9 (TNF receptor superfamily member 9).
• Source: E. coli
• Species: Mouse
• Tag: N-His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 20.5 kDa
  Accurate Molecular Mass: 20 kDa
• Protein length: Val24-Pro179
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1 mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 [ Mus musculus (house mouse) ]
• Official Symbol: Tnfrsf9
• Synonyms: TNFRSF9; tumor necrosis factor receptor superfamily, member 9; tumor necrosis factor receptor superfamily member 9; CD137 antigen; T-cell antigen 4-1BB; 4-1BB ligand receptor; secreted CD137 antigen; ILA; Ly63; 4-1BB; Cd137; CDw137; AA408498; AI325004; A930040I11Rik
• Gene ID: 21942
• mRNA Refseq: NM_001077508
• Protein Refseq: NP_001070976
• UniProt ID: P20334

Reviews

03/11/2022

Good heat resistance, long time treatment at high temperature, still has activity.

10/11/2021

The results obtained by SDS-PAGE or Western blot analysis were good.

07/30/2021

The purity is good, and the experimental results obtained are accurate.

Q&As

What diseases are associated with abnormal expression levels of TNFRSF9?

Studies have found that abnormal expression levels of TNFRSF9 may be associated with certain tumors, autoimmune diseases, and inflammatory diseases.

What is the association of TNFRSF9 with other cytokines?

It has a variety of associations with other proteins and cytokines. For example, it may interact with the NF-kB signaling pathway to regulate the inflammatory response, and it may also interact with apoptosis-related proteins to regulate the apoptosis process.

What are the main functions of TNFRSF9 in the human body?

TNFRSF9 mainly plays an important role in the immune system, as an activating signaling molecule, it is able to stimulate the activation, proliferation and survival of T cells and NK cells.

Are there potential therapeutic applications for TNFRSF9 inhibitors or activators?

Inhibitors or activators targeting TNFRSF9 may have potential applications for the treatment of certain tumors, autoimmune diseases, and inflammatory diseases.

How does TNFRSF9 bind to its ligands?

The extracellular domain of TNFRSF9 can bind to its ligand, such as 4-1BBL, to initiate signal transduction, which in turn activates downstream signaling pathways.

How is TNFRSF9 related to immuno-oncology?

TNFRSF9 has some potential in tumor immunotherapy. Several antibody drugs have been developed to use the stimulating effects of TNFRSF9 to enhance the activity of immune cells to fight tumors.