| Species : |
HPV18 |
| Source : |
E. coli |
| Tag : |
His |
| Protein Length : |
1-105 aa |
| Description : |
Human papillomavirus (HPV) E6 and E7 viral oncoproteins play the pivotal role in driving the cells toward oncogenesis. In their process of replicating the viral genome, they can induce all the hallmarks of a cancer cell, i.e., uncontrolled cellular proliferation, angiogenesis, invasion, metastasis, and unrestricted telomerase activity along with the evasion of apoptosis and growth suppressors’ activity. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Also plays a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta). |
| Form : |
Supplied as 0.2 μm filtered solution in 50 mM Tris, 500 mM NaCl, pH7.5 with glycerol as protectant. |
| Bio-activity : |
Immobilized HPV18 E7 Protein, His Tag at 1 μg/mL (100 μL/well) can bind HPV18 E7 antibody, Mouse lgG with a linear range of 0.05-3 ng/mL. |
| Molecular Mass : |
The protein has a calculated MW of 14.0 kDa. The protein migrates as 14-17 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE). |
| Purity : |
>90% as determined by SDS-PAGE. |
| Storage : |
This product is stable after storage at: The product MUST be stored at -70 centigrade or lower upon receipt; -70 centigrade for 3 months under sterile conditions. Please avoid repeated freeze-thaw cycles. |
| Concentration : |
0.2 mg/mL |
| Shipping : |
This product is supplied and shipped with dry ice, please inquire the shipping cost. |
