| Description : |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients |
| Source : |
CHO-K1 |
| Species : |
Human |
| Form : |
Lyophilized powder |
| Endotoxin : |
<20 EU/mg |
| Bio-activity : |
>2.0 x 10^4 IU/mg |
| Purity : |
>95.0% by high performance liquid chromatography (SEC-HPLC) and SDS-PAGE. |
| Storage Buffer : |
10mM Phosphate-Buffered Saline (pH 7.2) |
| Storage : |
Stable storage at 4℃ for 7-10 days; for long-term storage, please store at -20℃ after dispensing. |
| Sterility : |
Sterility |
| Instructions : |
It is recommended that lyophilized GMP rhBMP2 be dissolved in water for injection or sterilized ultrapure water at a concentration of not less than 100 μg/ml, pending further dilution to working concentration. |
