Active GMP Recombinant Mouse Fgf21 Protein, His-Tagged

Cat.No. : Fgf21-01M
Product Overview : GMP Recombinant Mouse Fgf21 Protein, His-Tagged was expressed in Escherichia coli cell-derived in an animal component free process under cGMP guidelines.
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Description : Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; cerebellum; integumental system; limb; and skeleton. Orthologous to human FGF21 (fibroblast growth factor 21)
Source : Escherichia coli
Species : Mouse
Tag : His
Form : Lyophilized
Bio-activity : Measure by its ability to induce proliferation in NIH‑3T3 mouse embryonic fibroblast cells in the presence of mouse Klotho beta and heparin. The ED50 for this effect is < 2 μg/mL.
AA Sequence : AYPIPDSSPLLQFGGQVRQRYLYTD DDQDTEAHLEIREDGTVVGAAHRSP ESLLELKALKPGVIQILGVKASRFL CQQPDGALYGSPHFDPEACSFRELL LEDGYNVYQSEAHGLPLRLPQKDSP NQDATSWGPVRFLPMPGLLHEPQDQ AGFLPPEPPDVGSSDPLSMVEPLQG RSPSYAS with polyhistidine tag at the N-terminus
Endotoxin : <0.1 EU per 1 μg of the protein by the LAL method.
Purity : >98% as determined by SDS-PAGE analysis. Purified by Ni-NTA chromatography.
Notes : Please use within one month after protein reconstitution.
Storage : Lyophilized protein should be stored at -20°C. Upon reconstitution, protein aliquots should be stored at -20°C or -80°C.
Storage Buffer : The protein was lyophilized from a solution containing 1X PBS, pH 8.0.
Reconstitution : It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.
SDS-PAGE:
Gene Name : Fgf21 fibroblast growth factor 21 [ Mus musculus (house mouse) ]
Official Symbol : Fgf21
Synonyms : Fgf8c
Gene ID : 56636
mRNA Refseq : NM_020013.4
Protein Refseq : NP_064397.1
UniProt ID : Q9JJN1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How is FGF21 expression regulated in adipose tissue? 10/31/2022

FGF21 expression in adipose tissue is regulated by various factors, including peroxisome proliferator-activated receptor gamma (PPARγ) activation.

What are the effects of FGF21 on lipid metabolism? 08/27/2020

FGF21 influences lipid metabolism by promoting the utilization of fatty acids for energy, contributing to the regulation of lipid homeostasis.

Can FGF21 be a biomarker for metabolic health? 08/07/2019

FGF21 levels are being explored as potential biomarkers for metabolic health, reflecting conditions such as insulin resistance and metabolic syndrome.

Is FGF21 involved in the regulation of insulin sensitivity? 03/03/2019

Yes, FGF21 plays a role in improving insulin sensitivity, making it a potential target for interventions in insulin resistance-associated conditions.

Does FGF21 have roles in energy expenditure? 11/11/2018

Yes, FGF21 influences energy expenditure by promoting thermogenesis in brown adipose tissue, contributing to overall metabolic regulation.

Are there gender-specific differences in FGF21 levels? 08/30/2017

Gender-specific differences in FGF21 levels have been reported, with some studies suggesting higher circulating FGF21 concentrations in females.

What signaling pathways does FGF21 activate? 01/09/2016

FGF21 activates signaling pathways such as the AMP-activated protein kinase (AMPK) pathway, which contributes to its metabolic effects.

Customer Reviews (3)

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Reviews
01/04/2022

    The manufacturer's history of producing high-quality products contributed to our trust in this protein.

    06/27/2021

      Collaboration with other research groups was made easier by the product's standardized use in the scientific community.

      03/03/2016

        The product's role in promoting collaboration and teamwork positively impacted the quality of our research.

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