Active Native Bovine TSH Protein

Cat.No. : TSH-1312B
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Description : Thyroid-stimulating hormone (TSH) is a pituitary hormone that stimulates the thyroid gland to produce thyroxine, and then triiodothyronine which stimulates the metabolism of almost every tissue in the body. It is a glycoprotein hormone synthesized and secreted by thyrotrope cells in the anterior pituitary gland, which regulates the endocrine function of the thyroid.
Source : Bovine
Species : Bovine
Form : Lyophilized powder
Bio-activity : ≥25 U/mg
Storage : Store at 2 centigrade to 8 centigrade
Reconstitution : Reconsititute with PBS or other buffer solutions.
Tag : Non
Official Symbol : TSH
Official Symbol : TSH

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (8)

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Reviews
07/11/2022

    Good for Bimo-lecular fluorescence complementation control.

    06/01/2020

      TSH manufacturer's products are consistently of the highest quality, with a strong commitment to purity, potency, and consistency.

      05/17/2020

        Work great in Western blot analysis.

        12/02/2019

          The purity is truly exceptional, with no visible impurities or contaminants.

          03/18/2019

            TSH is ideal for Western-blot analysis, with strong bands and clear specificity.

            04/09/2018

              Can save materials and shorten the experiment time in luci-ferase complementation assay.

              04/03/2018

                It was accurately quantified in expression analysis.

                03/11/2017

                  It is appropriate for T cell killing analysis.

                  Q&As (16)

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                  What the TSHR signal transduction, regulation, and maturation? 04/14/2023

                  The TSHR, long known to signal via cAMP, can induce both the phospholipase C (PLC) and the protein kinase A signal transduction systems. Intracellular Ca2+ and PLC regulate iodide efflux, H2O2 production, and thyroglobulin iodination, while adenylate cyclase and cAMP regulate iodide uptake and transcription of thyroglobulin (Tg), thyroid peroxidase (TPO), and the sodium-iodide symporter.

                  Why the puzzling size diversity of TSHRs detected by western blotting? 04/14/2023

                  Presumably by protein disulfide isomerase leading to release of the α subunit from the membrane-bound receptor.

                  What is associated with a high TSH value? 04/14/2023

                  High-normal TSH-values are associated with an adverse lipid profile, high blood pressure, high body mass index (BMI), metabolic syndrome and fatal coronary heart disease.

                  How is TSH level regulated in brain? 04/14/2023

                  It is known that the majority of the metabolically active T3 in the brain is not derived from the circulation, but produced locally by the effect of D2 on T4. Locally produced T3 largely acts on the hypothalamus and pituitary glands to control TSH levels.

                  Are TSH receptors expressed in places other than the thyroid gland? 04/14/2023

                  Thyroid stimulating hormone receptors have been identified in mammalian heart, bone, kidneys, brain, skin, adipose, hair follicles, thymus, lymphocytes, astrocyte cultures and in fish testes.

                  How can thyroid cancer be treated by inhibiting thyrotropin? 04/14/2023

                  Levothyroxine is recommended for long-term TSH suppression.

                  What cells or organs does TSH work on? 04/14/2023

                  Including thyroid,lymphocytes, the pituitary, thymus, testes, kidney, brain, adipose tissue, and fibroblasts.

                  What is the biological function of thyroid stimulating hormone (TSH)? 04/14/2023

                  The only established biologic function of thyroid stimulating hormone (TSH) is to regulate the synthesis and secretion of thyroid hormone from thyroid follicular cells.

                  How to achieve TSH transcription? 04/14/2023

                  In response to low circulating thyroid hormone levels, the basal medial hypothalamus releases thyrotropin-releasing hormone (TRH) which then stimulates production of thyroid-stimulating hormone (TSH) from the thyrotropes of the anterior pituitary gland.

                  Besides TSH, what other substances can stimulate the release of prolactin? 04/14/2023

                  Other substances like serotonin, gonadotropin-releasing hormone, and estrogen can also stimulate prolactin release.

                  What is the role of TSH protein in thyroid cancer? 12/24/2019

                  In thyroid cancer, the TSH protein may have a role in promoting the proliferation and growth of cancer cells. Therefore, for some high-risk groups, such as patients with postoperative thyroidectomy, inhibition of TSH protein production and activity can reduce the risk of cancer recurrence.

                  What factors regulate the secretion of TSH protein? 11/12/2019

                  The secretion of TSH protein is regulated by a variety of factors, including negative feedback regulation of the hypothalamic-pituitary-thyroid axis, thyroxine levels, and the regulatory mechanism of anterior pituitary cells.

                  Does the TSH protein have polymorphisms? 10/03/2019

                  The polymorphisms of the TSH protein are partly related to the genetic variation of individuals. TSH proteins of different genotypes may affect an individual's sensitivity to TSH and regulation of thyroid function.

                  How does TSH protein regulate thyroid function? 07/30/2019

                  TSH protein activates intracellular signaling pathways by binding to TSH receptors on the surface of thyroid cells, promoting thyroxine synthesis and secretion. It enhances the production of thyroxine by positively regulating iodine uptake, thyroglobulin synthesis, and thyroid peroxidase activity.

                  What are the applications of TSH protein in clinical diagnosis? 06/05/2019

                  The TSH protein plays a key role in clinical diagnosis. By measuring serum TSH levels, it is possible to assess whether the thyroid gland is functioning normally for diagnosis and follow-up of thyroid-related diseases.

                  Does the TSH protein interact with other proteins? 04/26/2019

                  Yes, the TSH protein can interact with TSH receptors on the surface of thyroid cells, triggering a series of signaling. In addition, TSH protein interacts with other cytokines and regulators to regulate thyroid function.

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