| Description : |
Toxin A from Clostridium difficile, also known as TcdA, is an enterotoxin that has glucosyltransferase and cysteine protease activities. It inactivates host Rho family GTPases by glucosylation, altering cytoskeletal structure, cell division, and cell-cell adhesion. Toxin A can induce activation of the inflammasome and apoptosis. While both toxin A and toxin B inactivate Rho family GTPases, toxin A has a higher binding affinity for epithelial cell surface carbohydrates. |
| Source : |
Clostridium difficile |
| Species : |
Clostridium difficile |
| Bio-activity : |
EC50 of < 0.2 ng/mL, as tested on Vero cells. |
| Purity : |
≥80% estimated by SDS-PAGE |
| Stability : |
≥ 2 years |
| Storage : |
At 4 centigrade. |
| Storage Buffer : |
50 mM Tris, 50 mM NaCl, pH 7.5, and 0.1% trahalose |
| Reconstitution : |
0.5 mL of water |
| Synonyms : |
TcdA; Toxin A |
| UniProt ID : |
P16154 |
