| Species : |
Clostridium difficile |
| Source : |
Clostridium difficile |
| Description : |
Toxin B from Clostridium difficile, also known as TcdB, is a cytotoxin that has glucosyltransferase and cysteine protease activities. It inactivates host Rho family GTPases by glucosylation, altering cytoskeletal structure, cell division, and cell-cell adhesion. Toxin B can induce activation of the inflammasome and apoptosis. While both toxin A and toxin B inactivate Rho family GTPases, toxin B more potently induces mammalian cell rounding in culture. |
| Bio-activity : |
EC50 of 1 pg/mL as tested on Vero cells. |
| Purity : |
≥90% estimated by SDS-PAGE |
| Storage : |
2-8 centigrade (as supplied) |
| Concentration : |
0.2 mg/mL |
| Storage Buffer : |
50 mM Tris, 100 mM NaCl, pH 7.5 |
