Active Native Clostridium difficile Toxin B Protein
| Cat.No. : | TcdB-189C |
| Product Overview : | Native Toxin B purified from Clostridium difficile. |
- Specification
- Gene Information
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| Description : | Toxin B from Clostridium difficile, also known as TcdB, is a cytotoxin that has glucosyltransferase and cysteine protease activities. It inactivates host Rho family GTPases by glucosylation, altering cytoskeletal structure, cell division, and cell-cell adhesion. Toxin B can induce activation of the inflammasome and apoptosis. While both toxin A and toxin B inactivate Rho family GTPases, toxin B more potently induces mammalian cell rounding in culture. |
| Source : | Clostridium difficile |
| Species : | Clostridium difficile |
| Bio-activity : | EC50 of 1 pg/mL as tested on Vero cells. |
| Purity : | ≥90% estimated by SDS-PAGE |
| Storage : | 2-8 centigrade (as supplied) |
| Concentration : | 0.2 mg/mL |
| Storage Buffer : | 50 mM Tris, 100 mM NaCl, pH 7.5 |
| Synonyms : | TcdB; Toxin B |
| UniProt ID : | P18177 |
| Synonyms : | TcdB; Toxin B |
| UniProt ID : | P18177 |
Products Types
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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