Active Recombinant Cynomolgus CTLA4 Protein, His-tagged, Alexa Fluor 647 conjugated
Cat.No. : | CTLA4-109CAF647 |
Product Overview : | Alexa Fluor 647 conjugated recombinant Cynomolgus CTLA4(Met1-Asp161) fused with His tag at C-terminal was expressed in HEK293. |
Unit | |
Price | |
Qty |
- Specification
- Gene Information
- Related Products
Description : | CTLA4 played an important role in many functions. |
Source : | HEK293 |
Species : | Monkey |
Tag : | His |
Form : | Lyophilized |
Bio-activity : | Immobilized Cynomolgus CTLA4-His at 10 μg/mL (100 μL/well) can bind Cynomolgus CD80-Fc, The EC50 of Cynomolgus CD80-Fc is 0.02-0.04 μg/mL. |
Molecular Mass : | The recombinant cynomolgus CTLA4 comprises 136 amino acids and has a calculated molecular mass of 14.9 kDa. The apparent molecular mass of it is approximately 24 and 21 kDa respectively in SDS-PAGE. |
Protein length : | Met1-Asp161, 136 |
N-terminal Sequence Analysis : | Ala 37 |
Endotoxin : | < 1.0 EU/ μg of the protein as determined by the LAL method. |
Purity : | (73.4+23.7) % as determined by SDS-PAGE |
Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 647 via amines Excitation = 650 nm Emission = 668 nm |
Stability : | Samples are stable for up to 12 months from date of receipt at -70 centigrade. |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. |
Shipping : | Shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Gene Name : | CTLA4 cytotoxic T-lymphocyte associated protein 4 [ Macaca fascicularis ] |
Official Symbol : | CTLA4 |
Synonyms : | CTLA4; cytotoxic T-lymphocyte associated protein 4 |
Gene ID : | 102115124 |
Products Types
◆ Recombinant Protein | ||
CTLA4-2073P | Recombinant CTLA4 Protein, His-Flag-StrepII-tagged | +Inquiry |
CTLA4-647C | Recombinant Cynomolgus monkey CTLA4 Protein | +Inquiry |
Ctla4-038M | Active Recombinant Mouse Ctla4 Protein, Fc-tagged | +Inquiry |
CTLA4-654M | Recombinant Mouse CTLA4 Protein, Fc-tagged | +Inquiry |
Ctla4-652H | Recombinant Human Ctla4 Protein, Strep-tagged | +Inquiry |
◆ Lysates | ||
CTLA4-2179MCL | Recombinant Mouse CTLA4 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1713 | CTLA4[Biotinylated]:B7-2 Inhibitor Screening Assay Kit | +Inquiry |
Kit-1712 | CTLA4:B7-1[Biotinylated] Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, several clinical trials are investigating the combination of CTLA-4 inhibitors with PD-1 inhibitors and other immunotherapies to improve the overall effectiveness of cancer treatment.
CTLA-4 is expressed on various immune cells, including T cells, regulatory T cells (Tregs), and some B cells, contributing to its diverse immunoregulatory functions.
Modulating CTLA-4 may have applications in organ transplantation by suppressing the immune response against transplanted tissues and reducing the risk of rejection.
CTLA-4 is involved in the suppression of autoreactive T cells, contributing to the prevention of autoimmune responses by maintaining immune tolerance.
While both CTLA-4 and PD-1/PD-L1 inhibitors enhance anti-tumor immune responses, they target different checkpoints in the immune system. CTLA-4 primarily regulates T-cell activation in the early stages, whereas PD-1/PD-L1 acts later in the immune response.
Customer Reviews (3)
Write a reviewIt has become an indispensable tool in my experiments, consistently meeting my needs and providing valuable insights.
The CTLA4 protein is a top-quality product that is sure to fulfill my experimental requirements.
the ease of use and compatibility of the CTLA4 protein with various techniques further enhances its appeal.
Ask a Question for All CTLA4 Products
Required fields are marked with *
My Review for All CTLA4 Products
Required fields are marked with *
Inquiry Basket