| Cat. No. : |
IL2-255E |
| Description : |
Interleukin-2 (IL-2) is an interleukin, a type of cytokine immune system signaling molecule, which is a leukocytotrophic hormone that is instrumental in the body"s natural response to microbial infection and in discriminating between foreign (non-self) and self. IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes, the cells that are responsible for immunity. |
| Source : |
Yeast. |
| Formulation/ Reconstitution : |
Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein. |
| Purification : |
Ion-exchange chromatography. |
| Purity : |
>95% as visualized by SDS-PAGE analysis. |
| Amino Acid Sequence : |
APTSSSKRET QQQLKQLQMD LKLLLEGVNN NKNPKLSKML TFKINMPKKA TELKHLQCLE EELKPLEEML KNFLSKDIKE LMSNINVTVL GLKGSETRFT CEYDDETGTI VEFLNKWITF CQSIFSTMT. |
| Bioactivity : |
The biological activity of equine IL-2 was measured in a cell proliferation assay using carboxyfluoresein diacetate succinimidyl ester-loaded equine PBMC. The ED50 for this effect is typically 0.5 – 1.0 ng/mL. |
| Stability And Storage : |
Stable for up to twelve months from date of receipt at -20°C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles. |
| Pathways : |
Allograft rejection; Autoimmune thyroid disease; Cytokine-cytokine receptor interaction; Graft-versus-host disease; Intestinal immune network for IgA production; Jak-STAT signaling pathway; T cell receptor signaling pathway; Type I diabetes mellitus |
