Active Recombinant Full Length Human LACC1 Protein, C-Flag-tagged

• Cat.No.: LACC1-445HFL
• Product Overview: Recombinant Full Length Human LACC1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes an oxidoreductase that promotes fatty-acid oxidation, with concomitant inflammasome activation, mitochondrial and NADPH-oxidase-dependent reactive oxygen species production, and bactericidal activity of macrophages. The encoded protein forms a complex with fatty acid synthase on peroxisomes and is thought to be modulated by peroxisome proliferator-activated receptor signaling events. Naturally occurring mutations in this gene are associated with inflammatory bowel disease, Behcet's disease, leprosy, ulcerative colitis, early-onset Crohn's disease, and systemic juvenile idiopathic arthritis.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Bio-activity: Enzyme activity
• Molecular Mass: 47.6 kDa
• AA Sequence: MAEAVLIDLFGLKLNSQKNCHQTLL KTLNAVQYHHAAKAKFLCIMCCSNI SYERDGEQDNCEIETSNGLS ALLEEFEIVSCPSMAATLYTIKQKI DEKNLSSIKVIVPRHRKTLMKAFID QLFTDVYNFEFEDLQVTFRG GLFKQSIEINVITAQELRGIQNEIE TFLRSLPALRGKLTIITSSLIPDIF IHGFTTRTGGISYIPTLSSF NLFSSSKRRDPKVVVQENLRRLANA AGFNVEKFYRIKTHHSNDIWIMGRK EPDSYDGITTNQRGVTIAAL GADCIPIVFADPVKKACGVAHAGWK GTLLGVAMATVNAMIAEYGCSLEDI VVVLGPSVGPCCFTLPRESA EAFHNLHPACVQLFDSPNPCIDIRK ATRILLEQGGILPQNIQDQNQDLNL CTSCHPDKFFSHVRDGLNFG
  TQIGFISIKETRTRPLEQKLISEED LAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.

Gene Information

• Gene Name: LACC1 laccase domain containing 1 [ Homo sapiens (human) ]
• Official Symbol: LACC1
• Synonyms: FAMIN; JUVAR; C13orf31
• Gene ID: 144811
• mRNA Refseq: NM_153218.4
• Protein Refseq: NP_694950.2
• MIM: 613409
• UniProt ID: Q8IV20