Active Recombinant Full Length Human ROR1 Protein, C-Flag-tagged

• Cat.No.: ROR1-140HFL
• Product Overview: Recombinant Full Length Human ROR1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Bio-activity: ELISA capture for autoantibodies
  WB positive control
  Affinity purification chromatography
• Molecular Mass: 104.1 kDa
• AA Sequence: MHRPRRRGTRPPLLALLAALLLAAR GAAAQETELSVSAELVPTSSWNISS ELNKDSYLTLDEPMNNITTS LGQTAELHCKVSGNPPPTIRWFKND APVVQEPRRLSFRSTIYGSRLRIRN LDTTDTGYFQCVATNGKEVV SSTGVLFVKFGPPPTASPGYSDEYE EDGFCQPYRGIACARFIGNRTVYME SLHMQGEIENQITAAFTMIG TSSHLSDKCSQFAIPSLCHYAFPYC DETSSVPKPRDLCRDECEILENVLC QTEYIFARSNPMILMRLKLP NCEDLPQPESPEAANCIRIGIPMAD PINKNHKCYNSTGVDYRGTVSVTKS GRQCQPWNSQYPHTHTFTAL RFPELNGGHSYCRNPGNQKEAPWCF TLDENFKSDLCDIPACDSKDSKEKN KMEILYILVPSVAIPLAIAL LFFFICVCRNNQKSSSAPVQRQPKH VRGQNVEMSMLNAYKPKSKAKELPL SAVRFMEELGECAFGKIYKG HLYLPGMDHAQLVAIKTLKDYNNPQ QWMEFQQEASLMAELHHPNIVCLLG AVTQEQPVCMLFEYINQGDL HEFLIMRSPHSDVGCSSDEDGTVKS SLDHGDFLHIAIQIAAGMEYLSSHF FVHKDLAARNILIGEQLHVK ISDLGLSREIYSADYYRVQSKSLLP IRWMPPEAIMYGKFSSDSDIWSFGV VLWEIFSFGLQPYYGFSNQE VIEMVRKRQLLPCSEDCPPRMYSLM TECWNEIPSRRPRFKDIHVRLRSWE GLSSHTSSTTPSGGNATTQT TSLSASPVSNLSNPRYPNYMFPSQG ITPQGQIAGFIGPPIPQNQRFIPIN GYPIPPGYAAFPAAHYQPTG PPRVIQHCPPPKSRSPSSASGSTST GHVTSLPSSGSNQEANIPLLPHMSI PNHPGGMGITVFGNKSQKPY
  KIDSKQASLLGDANIHGHTESMISA ELTRTRPLEQKLISEEDLAANDILD YKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protein Kinase, Transmembrane

Gene Information

• Gene Name: ROR1 receptor tyrosine kinase like orphan receptor 1 [ Homo sapiens (human) ]
• Official Symbol: ROR1
• Synonyms: NTRKR1; dJ537F10.1
• Gene ID: 4919
• mRNA Refseq: NM_005012.4
• Protein Refseq: NP_005003.2
• MIM: 602336
• UniProt ID: Q01973