Active Recombinant Full Length Human STAT3, His-tagged

Cat.No. : STAT3-29823TH
Product Overview : Recombinant full length Human STAT3 with His tag, Predicted MWt 89 kDa.
Availability July 21, 2024
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Description : The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Conjugation : HIS
Source : E. coli
Tissue specificity : Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Biological activity : 1 unit equals 1 nanogram of purified protein.
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 20% Glycerol, 20mM Tris HCl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 7.9
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the transcription factor STAT family.Contains 1 SH2 domain.
Publication :
TrkA Interacts with and Phosphorylates STAT3 to Enhance Gene Transcription and Promote Breast Cancer Stem Cells in Triple-Negative and HER2-Enriched Breast Cancers (2021)
An FDA-Approved Antifungal, Ketoconazole, and Its Novel Derivative Suppress tGLI1-Mediated Breast Cancer Brain Metastasis by Inhibiting the DNA-Binding Activity of Brain Metastasis-Promoting Transcription Factor tGLI1 (2021)
Gene Name : STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) [ Homo sapiens ]
Official Symbol : STAT3
Synonyms : STAT3; signal transducer and activator of transcription 3 (acute-phase response factor); signal transducer and activator of transcription 3; APRF;
Gene ID : 6774
mRNA Refseq : NM_003150
Protein Refseq : NP_003141
MIM : 102582
Uniprot ID : P40763
Chromosome Location : 17q21
Pathway : Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Adipogenesis, organism-specific biosystem;
Function : CCR5 chemokine receptor binding; DNA binding; calcium ion binding; glucocorticoid receptor binding; ligand-regulated transcription factor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
11/17/2022

    Protein worked well in assay.

    04/21/2021

      Fast shipping, great customer service.

      02/06/2018

        Excellent purity, highly recommend.

        Q&As (7)

        Ask a question
        Are there any known inhibitors targeting STAT3 for therapeutic purposes? 02/01/2022

        Yes, there are several inhibitors targeting STAT3, including Stattic, S3I-201, and OPB-31121, which are being explored for their therapeutic potential in cancer and other diseases.

        Can STAT3 activation influence cell proliferation and survival? 11/16/2021

        Yes, activated STAT3 can promote cell proliferation and survival by inducing the expression of genes like cyclin D1 and Bcl-xL.

        How does STAT3 contribute to oncogenesis and tumor progression? 04/12/2021

        STAT3 can contribute to oncogenesis by promoting cell proliferation, survival, angiogenesis, and immune evasion, and by suppressing apoptosis in various cancer types.

        How can the activation of STAT3 be detected in cells? 02/24/2021

        Activation of STAT3 can be detected using Western blotting with phospho-specific antibodies that recognize the tyrosine-phosphorylated form of STAT3.

        How does STAT3 interact with other signaling pathways in the cell? 08/25/2020

        STAT3 can interact with other signaling pathways such as the MAPK, PI3K/AKT, and NF-κB pathways, leading to integrated cellular responses.

        What are the primary upstream activators of STAT3? 01/02/2019

        The primary upstream activators of STAT3 are cytokines and growth factors, especially those that signal through the Janus kinase (JAK) family, such as IL-6 and EGF.

        What role does STAT3 play in immune cell differentiation and function? 04/16/2018

        STAT3 plays a crucial role in the differentiation of Th17 cells, a subset of CD4+ T cells, and is also involved in the function of myeloid-derived suppressor cells (MDSCs) and regulatory T cells, influencing immune responses.

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