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Active Recombinant Human Basic Fibroblast Growth Factor

Cat.No. : FGF2-5H
Product Overview : Human basic FGF is produced by genetically engineered yeast, and purified by heparin-Sepharose affinity chromatography.
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Description : Human Basic Fibroblast Growth Factor is a mitogen that stimulates cell growth for such cells as fibroblasts, endothelial cells, myoblasts, glial cells and smooth muscle cells. Basic FGF is composed of 146 amino acid residues (pro 1 to ser 146), and is 55% homologous with acidic FGF, including two conserved cysteine residues.
Source : yeast
Species : Human
Form : Lyophilized powder
Bio-activity : The mitogenic activity of human basic FGF is identical to natural bovine basic FGF, as measured by stimulation of 3H-thymidine incorporation into human foreskin fibroblast cells.
Molecular Mass : 17.5 KDa
Purity : Over 95% pure by N-terminal amino acid sequencing, amino acid composition, HPLC analysis, and SDS gel electrophoresis.
Stability : Several months, lyophilized or in solution, at pH 6-7 and +4°C.
Storage : Store at +4°C. Reconstitution is best in water or buffer near neutral pH, since it is unstable in acidic solutions. After reconstitution, storage in aliquots at -80°C is recommended.
Gene Name : FGF2 fibroblast growth factor 2 (basic) [ Homo sapiens (human) ]
Official Symbol : FGF2
Synonyms : FGF2; fibroblast growth factor 2 (basic); BFGF; FGFB; HBGF-2; fibroblast growth factor 2; prostatropin; heparin-binding growth factor 2; basic fibroblast growth factor Bfgf; Basic fibroblast growth factor
Gene ID : 2247
mRNA Refseq : NM_002006
Protein Refseq : NP_001997
MIM : 134920
UniProt ID : P09038
Chromosome Location : 4q26
Pathway : Activated point mutants of FGFR2; Adaptive Immune System; Angiopoietin receptor Tie2-mediated signaling
Function : chemoattractant activity; cytokine activity; fibroblast growth factor receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the biological function of FGF2? 11/10/2022

FGF2 promotes cell migration and angiogenesis and regulates bone homeostatic balance.

Where is FGF2 mainly expressed? 10/22/2022

FGF2 is widely expressed in the nervous system.

In which tissues of sheep is FGF2 primarily expressed? 01/01/2022

FGF2 is mainly expressed in tissues such as mammary glands and ovaries of sheep.

What protein does FGF2 share high homology with? 03/08/2021

FGF1 has a high degree of homology with FGF2.

What diseases is FGF2 involved in? 02/12/2021

FGF2 is involved in diseases such as cardiovascular disease, breast disease and bone homeostasis.

How does FGF2 regulate bone homeostasis? 11/21/2020

FGF2 negatively regulates bone homeostasis.

Customer Reviews (2)

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Reviews
07/14/2022

    The technical expert communicated with me in time to understand the progress of my experiment and gave me suggestions for improvement.

    02/04/2022

      The purchased protein is suitable for WB experiments and I am satisfied with the results.

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