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Active Recombinant Human BMP2

Cat.No. : BMP2-23H
Product Overview : Recombinant, human bone morphogenetic protein-2(BMP-2) expressed in CHO cell and purified byproprietary chromatographic methods.
  • Specification
  • Gene Information
  • Related Products
Description : BMP-2 is a homodimeric protein that belongs to the transforming growth factor β (TGF-β) superfamily. BMP-2 is known to regulate diverse fundamental processes during embryonic development. BMP-2 have also been shown to regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells.
Source : CHO Cells
Species : Human
Form : Lyophilized from a 0.2 μm filtered solution in 0.2% sucrose, 2.5% Glycine, 0.01% polysorbate 80, 0.01%sodium chloride, 3% mannitol per 1 μg of BMP-2.
Bio-activity : The ED50 as determined by cytolysis of ATDC-5 cell is less than 50 ng/ml.
Molecular Mass : The molecule has a calculated molecular mass of approximately 26 kDa. Due to glycosylation, rhBMP-2migrates as an approximately 36 kDa protein under non-reducing conditions and as a 17 - 18 kDa proteinunder reducing conditions in SDS-PAGE.
Endotoxin : <0.5 eu per 1 μg of bmp-2 as determined by the lal</0.5
Purity : >95% as determined by SEC-HPLC and SDS-PAGE.
Storage : Lyophilized samples are stable for up to six months at -20° C to -70° C.
Reconstitution : Reconstitute to 100 μg/mL with sterile distilled water. Further dilutions can be made in aqueous buffersjust prior to use.
Gene Name : BMP2 bone morphogenetic protein 2 [ Homo sapiens ]
Official Symbol : BMP2
Synonyms : BMP2; bone morphogenetic protein 2; BMP2A; BMP-2A; bone morphogenetic protein 2A; BDA2;
Gene ID : 650
mRNA Refseq : NM_001200
Protein Refseq : NP_001191
MIM : 112261
UniProt ID : P12643
Chromosome Location : 20p12
Pathway : Adipogenesis, organism-specific biosystem; BMP Signalling Pathway, organism-specific biosystem; Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Heart Development, organism-specific biosystem;
Function : BMP receptor binding; SMAD binding; activin receptor activity, type II; cytokine activity; growth factor activity; phosphatase activator activity; protein binding; protein domain specific binding; protein heterodimerization activity; protein homodimerization activity; receptor binding; retinol dehydrogenase activity; transmembrane receptor protein serine/threonine kinase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.



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