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Active Recombinant Human BMP2 Protein (Gln283-Arg396), GMP Grade

Cat.No. : BMP2-08HG
Product Overview : GMP recombinant human BMP-2 protein (Gln283-Arg396) without tag was expressed in Chinese Hamster Ovary cell line and manufactured and tested under current Good Manufacturing Practice (GMP) guidelines.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients.
Source : CHO
Species : Human
Form : Disulfide-linked homodimer
Bio-activity : Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 40-200 ng/mL.
The specific activity of recombinant human BMP-2 is >5.0 x 105 units/mg, which is calibrated against the human BMP-2 WHO Standard.
Molecular Mass : Predicted Molecular Mass: 13 kDa (monomer)
SDS-PAGE: 15-16, kDa, reducing conditions
Protein Length : Gln283-Arg396
N-terminal Sequence Analysis : Gln-Ala-Lys-His-Lys-Gln-Arg-Lys-Arg-Leu
Endotoxin : <0.10 EU/ μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE with silver staining, under reducing conditions.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
A minimum of 12 months when stored at ≤ -20 centigrade as supplied. Refer to lot specific COA for the Use by Date.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, ≤ -20 centigrade under sterile conditions after reconstitution.
Storage Buffer : Lyophilized from a 0.2 μm filtered solution in Glycine, Sucrose, Tween® 80 and Glutamic Acid.
Reconstitution : Reconstitute at 100 μg/mL in 4 mM HCl.
Shipping : The product is shipped with polar packs.
Gene Name : BMP2 bone morphogenetic protein 2 [ Homo sapiens ]
Official Symbol : BMP2
Synonyms : BMP2; bone morphogenetic protein 2; BMP2A; BMP-2A; bone morphogenetic protein 2A; BDA2;
Gene ID : 650
mRNA Refseq : NM_001200
Protein Refseq : NP_001191
MIM : 112261
UniProt ID : P12643

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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