Active Recombinant Human CD86 protein, Fc-tagged

Cat.No. : CD86-2903H
Product Overview : Recombinant Human CD86 protein(Leu 26-Pro 247), fused with Fc tag, was expressed in HEK293.
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Source : HEK293
Species : Human
Tag : Fc
Form : Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 10 mM NaCl, pH7.5 with trehalose as protectant.
Bio-activity : Immobilized Human B7-2, Fc Tag, premium grade at 5 μg/mL (100 μL/well) can bind Biotinylated Human CTLA-4, Fc,Avitag with a linear range of 0.6-10 ng/mL.Immobilized Biotinylated Mouse CD28, His,Avitag at 1 μg/mL (100 μL/well) on Streptavidin precoated (0.5 μg/well) plate, can bind Human B7-2, Fc Tag, premium grade with a linear range of 5-78 ng/mL.Immobilized Biotinylated Human / Cynomolgus / Rhesus macaque CD28, His,Avitag at 1 μg/mL (100 μL/well) on Streptavidin precoated (0.5 μg/well) plate, can bind Human B7-2, Fc Tag, premium grade with a linear range of 2-78 ng/mL.
Molecular Mass : This protein carries a human IgG1 Fc tag at the C-terminusThe protein has a calculated MW of 51.5 kDa. The protein migrates as 66-100 kDa under reducing (R) condition, and 120-140 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Protein Length : Leu 26-Pro 247
Endotoxin : Less than 0.01 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Storage : For long term storage, the product should be stored at lyophilized state at-20°C or lower.Please avoid repeated freeze-thaw cycles. This product is stable after storage at:-20°C to-70°C for 12 months in lyophilized state;-70°C for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : CD86 CD86 molecule [ Homo sapiens ]
Official Symbol : CD86
Synonyms : CD86; CD86 molecule; CD28LG2, CD86 antigen (CD28 antigen ligand 2, B7 2 antigen); T-lymphocyte activation antigen CD86; B lymphocyte antigen B7 2; B7 2; B7.2; BU63; FUN-1; CTLA-4 counter-receptor B7.2; B-lymphocyte activation antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); B70; B7-2; LAB72; CD28LG2; MGC34413;
Gene ID : 942
mRNA Refseq : NM_001206924
Protein Refseq : NP_001193853
MIM : 601020
UniProt ID : P42081

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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01/09/2022

    With the CD86 protein's high-quality composition and reliability, researchers can confidently proceed with their studies, knowing that they have access to a protein that consistently delivers accurate results.

    05/30/2021

      Its high purity and stability ensure reliable and reproducible results, which are paramount for achieving meaningful scientific outcomes.

      12/08/2017

        The CD86 protein is renowned for its outstanding quality, making it an optimal choice to fulfill the requirements of my experimental investigations.

        Q&As (5)

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        Are there any ongoing clinical trials involving CD86 inhibitors? 02/18/2023

        Yes, several clinical trials are investigating the efficacy of CD86 inhibitors in various diseases, including autoimmune disorders and certain cancers.

        How does CD86 contribute to transplant medicine? 02/03/2021

        In transplantation, CD86 blockade is investigated as a potential strategy to modulate the immune response and prevent graft rejection by inhibiting excessive T cell activation.

        How does CD86 influence the balance between Th1 and Th2 immune responses? 08/26/2019

        CD86 signaling is involved in the differentiation of T helper cells. Modulating CD86 levels may influence the balance between Th1 and Th2 responses, which is relevant in various immune-mediated diseases.

        Can CD86 be used as a prognostic marker in certain diseases? 12/29/2018

        There is emerging evidence suggesting that CD86 expression levels may have prognostic value in certain diseases, guiding clinicians in predicting disease outcomes.

        How does CD86 influence the development of regulatory T cells (Tregs)? 10/02/2016

        CD86 signaling is involved in the development and function of regulatory T cells, which play a crucial role in maintaining immune tolerance and preventing autoimmune reactions.

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