Active Recombinant Human CDH10 protein, Fc-tagged

• Cat.No.: CDH10-41H
• Product Overview: Recombinant Human CDH10(Glu23-Ala613) fused with Fc tag at C-terminal was expressed in CHO.

Specification

• Species: Human
• Source: CHO
• Tag: Fc
• Protein Length: Glu23-Ala613
• Predicted N Terminal: Glu23 & Gly55
• Form: Lyophilized from a 0.2 μm filtered solution in PBS.
• Bio-activity: Measured by the ability of the immobilized protein to support the adhesion of BCE C/D‑1b bovine corneal endothelial cells. The ED50 for this effect is typically 0.1-0.4 μg/mL.Optimal dilutions should be determined by each laboratory for each application.
• Molecular Mass: Predicted Molecular Mass: 92.7 (monomer) kDa;SDS-PAGE: 100-120 kDa, reducing conditions.
• Endotoxin: <0.01 EU per 1 mug of the protein by the LAL method.
• Purity: >90%, by SDS-PAGE under reducing conditions and visualized by silver stain
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 centigrade as supplied.1 month, 2 to 8 centigrade under sterile conditions after reconstitution.3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
• Reconstitution: Reconstitute at 100 μg/mL in PBS.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
• Publications:
  Raludotatug Deruxtecan, a CDH6-Targeting Antibody–Drug Conjugate with a DNA Topoisomerase I Inhibitor DXd, Is Efficacious in Human Ovarian and Kidney Cancer Models (2024)

Gene Information

• Gene Name: CDH10 cadherin 10, type 2 (T2-cadherin) [ Homo sapiens ]
• Official Symbol: CDH10
• Synonyms: CDH10; cadherin 10, type 2 (T2-cadherin); cadherin-10; T2-cadherin
• Gene ID: 1008
• mRNA Refseq: NM_006727
• Protein Refseq: NP_006718
• MIM: 604555
• UniProt ID: Q9Y6N8
• Chromosome Location: 5p14.2
• Pathway: Adherens junctions interactions, organism-specific biosystem; Cell junction organization, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem; Cell-cell junction organization, organism-specific biosystem
• Function: calcium ion binding