Active Recombinant Human CXCL12, His-tagged
Cat.No. : | CXCL12-21H |
Product Overview : | Human N-his-tag SDF-1 β produced in E. coli is non-glycosylated polypeptide chain containing 100 amino acids (28-100 a.a; predicted MW=11.67kDa). The SDF-1 β is fused to 28 amino acid His-tag at N-terminal. The recombinant protein was purified by Ni-NTA affinity column and followed by gel filtration chromatography. |
- Specification
- Gene Information
- Related Products
Description : | SDF-1 (stromal cell-derived factor-1), also called CXCL12, is small cytokine belonging to the chemokine family. The two forms, SDF-1 alpha/CXCL12a and SDF-1 β/CXCL12b, are produced in cells by alternate splicing of the same gene. SDF-1 signal through its receptor CXCR4, and have been shown to chemoattract B and T cells, induce migration of CD34+ stem cells. Additionally, SDF-1 and its receptor CXCR4 are involved in human disease states (e.g. HIV/AIDS) and cancer metastasis. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Lyophilized from a 0.22μm filtered solution at a concentration of 1mg/ml in PBS. |
Bio-activity : | The protein was active in ELISA assay with an EC50 of about 160nM. |
Molecular Mass : | The measure MW in LC-MS was 11548 Dalton, in agreement with its theoretic molecular weight. |
AA Sequence : | MGSSHHHHHHSSGLVPRGSHMENLY FQGKPVSLSYRCPCRFFESHVARAN VKHLKILNTPNCALNNRQVCIDPKL KWIQEYLEKALNKRFKM |
Purity : | Purity was greater than 95% by Coomassie blue staining SDS-PAGE |
Storage : | Upon reconstitution, the preparation is stable for up to 1 month at 2-8°C. For long term storage, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles. |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water to a concentration of 1.0 mg/ml. |
Gene Name : | CXCL12 chemokine (C-X-C motif) ligand 12 [ Homo sapiens ] |
Official Symbol : | CXCL12 |
Synonyms : | CXCL12; chemokine (C-X-C motif) ligand 12; SDF1, SDF1A, SDF1B, stromal cell derived factor 1; stromal cell-derived factor 1; PBSF; SCYB12; SDF 1a; SDF 1b; TLSF a; TLSF b; TPAR1; intercrine reduced in hepatomas; pre-B cell growth-stimulating factor; IRH; SDF1; TLSF; SDF1A; SDF1B; |
Gene ID : | 6387 |
mRNA Refseq : | NM_000609 |
Protein Refseq : | NP_000600 |
MIM : | 600835 |
UniProt ID : | P48061 |
Chromosome Location : | 10q11.1 |
Pathway : | Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; |
Function : | CXCR chemokine receptor binding; chemokine activity; growth factor activity; receptor binding; |
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◆ Lysates | ||
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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