Active Recombinant Human DPP4 Protein (29-766aa), C-hIgG-tagged

Cat.No. : DPP4-10H
Product Overview : Recombinant human DPPIV/CD26 (29-766aa), fused to hIgG-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.
Availability November 13, 2024
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Description : DPP4, dipeptidyl peptidase-4 is a complex enzyme expressed on the surface of most cell types and is a serine exopeptidase that cleaves x-proline dipeptides from the N-terminus of polypeptides. DPP4 protein is associated with intracellular signal transduction, apoptosis and plays an important role in tumor biology. There are at least 63 substrates which can bind specifically to DPP4 enzyme including growth factors, chemokines, neuro peptides. Furthermore, DPP4 plays a major role in glucose metabolism by cleaving incretins such as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). Middle East respiratory syndrome coronavirus has been found to bind to DPP4. It is found on the surface of cells in the airways and kidneys.
Source : HEK293
Species : Human
Tag : Fc
Form : Liquid
Bio-activity : 1.Measured by its binding ability in a functional ELISA with MERS-CoV Spike S1 Subunit. The ED50 range ≤250 ng/mL.
2.Measured by its binding ability in a functional ELISA with MERS-CoV Spike RBD. The ED50 range ≤200 ng/mL.
3.Measured by its binding ability in a functional ELISA with MERS-CoV Spike. The ED50 range ≤120 ng/mL.
4.Specific activity is > 15,000 pmol/min/μg in which one unit defined as the amount of enzyme that hydrolyze 1pmole of H-Gly-Pro-AMC.HBr to H-Gly-Pro and AMC per minute at pH 8.0 at 37 centigrade.
Molecular Mass : 112.1 kDa (977 aa)
Protein length : 29-766 aa
AA Sequence : NKGTDDATADSRKTYTLTDYLKNTY RLKLYSLRWISDHEYLYKQENNILV FNAEYGNSSVFLENSTFDEFGHSIN DYSISPDGQFILLEYNYVKQWRHSY TASYDIYDLNKRQLITEERIPNNTQ WVTWSPVGHKLAYVWNNDIYVKIEP NLPSYRITWTGKEDIIYNGITDWVY EEEVFSAYSALWWSPNGTFLAYAQF NDTEVPLIEYSFYSDESLQYPKTVR VPYPKAGAVNPTVKFFVVNTDSLSS VTNATSIQITAPASMLIGDHYLCDV TWATQERISLQWLRRIQNYSVMDIC DYDESSGRWNCLVARQHIEMSTTGW VGRFRPSEPHFTLDGNSFYKIISNE EGYRHICYFQIDKKDCTFITKGTWE VIGIEALTSDYLYYISNEYKGMPGG RNLYKIQLSDYTKVTCLSCELNPER CQYYSVSFSKEAKYYQLRCSGPGLP LYTLHSSVNDKGLRVLEDNSALDKM LQNVQMPSKKLDFIILNETKFWYQM ILPPHFDKSKKYPLLLDVYAGPCSQ KADTVFRLNWATYLASTENIIVASF DGRGSGYQGDKIMHAINRRLGTFEV EDQIEAARQFSKMGFVDNKRIAIWG WSYGGYVTSMVLGSGSGVFKCGIAV APVSRWEYYDSVYTERYMGLPTPED NLDHYRNSTVMSRAENFKQVEYLLI HGTADDNVHFQQSAQISKALVDVGV DFQAMWYTDEDHGIASSTAHQHIYT HMSHFIKQCFSLP
Endotoxin : < 1 EU/μg of protein (determined by LAL method)
Purity : > 95% by SDS-PAGE
Applications : SDS-PAGE, Enzyme Activity, Bioactivity
Notes : For research use only. This product is not intended or approved for human, diagnostics or veterinary use.
Storage : Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 0.25 mg/mL (determined by Absorbance at 280 nm)
Storage Buffer : Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Gene Name : DPP4 dipeptidyl-peptidase 4 [ Homo sapiens (human) ]
Official Symbol : DPP4
Synonyms : DPP4; dipeptidyl-peptidase 4; ADCP2, adenosine deaminase complexing protein 2 , CD26, dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); dipeptidyl peptidase 4; DPPIV; ADCP-2; DPP IV; dipeptidylpeptidase 4; dipeptidyl peptidase IV; T-cell activation antigen CD26; adenosine deaminase complexing protein 2; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); CD26; ADABP; ADCP2; TP103
Gene ID : 1803
mRNA Refseq : NM_001935
Protein Refseq : NP_001926
MIM : 102720
UniProt ID : P27487

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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09/13/2019

    Its purity and efficacy make it an ideal choice for precise and accurate analysis, allowing me to generate reliable results.

    01/27/2019

      By incorporating the DPP4 Protein into their studies, scientists can confidently conduct their research, ushering in groundbreaking discoveries and novel insights within their respective domains.

      12/14/2016

        Its exceptional purity and functionality make it an ideal choice for accurate and precise analysis, ensuring reliable and reproducible results.

        Q&As (5)

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        How does DPP4 relate to diabetes? 04/17/2023

        DPP4 plays a crucial role in glucose homeostasis by cleaving incretin hormones. In diabetes, inhibiting DPP4 can enhance the action of these hormones, promoting insulin release and lowering blood sugar levels.

        Are there any side effects associated with DPP4 inhibitors? 01/11/2022

        Common side effects of DPP4 inhibitors include respiratory and urinary tract infections, headache, and nasopharyngitis. However, they are generally well-tolerated.

        What clinical applications does DPP4 have in managing type 2 diabetes? 06/12/2020

        Inhibitors of DPP4 are used in the treatment of type 2 diabetes to improve glycemic control. They work by prolonging the activity of incretin hormones, such as GLP-1, which stimulate insulin secretion.

        Can DPP4 inhibitors be used as a monotherapy for diabetes? 03/10/2020

        DPP4 inhibitors are often used as monotherapy or in combination with other antidiabetic medications to achieve optimal glycemic control.

        How do DPP4 inhibitors differ from other diabetes medications? 06/11/2016

        DPP4 inhibitors work by enhancing the effects of incretin hormones, while other diabetes medications may act on insulin sensitivity, insulin release, or glucose absorption.

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