Active Recombinant Human DPP4 Protein, His-tagged
Cat.No. : | DPP4-608H |
Product Overview : | Recombinant human DPP4 (29-766) Protein was expressed in CHO cells using a C-terminal His tag. |
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Description : | The DPP4 gene encodes dipeptidyl peptidase 4, which is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Dipeptidyl peptidase 4 is highly involved in glucose and insulin metabolism, as well as in immune regulation. This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and protein modeling suggests that it may play a similar role with SARS-CoV-2, the virus responsible for COVID-19. |
Source : | CHO |
Species : | Human |
Tag : | His |
Bio-activity : | Binding ability measured in a functional ELISA. MERS Spike Protein RBD can bind to immobilized DPP4(29-766) protein. |
Molecular Mass : | ~84 kDa |
Protein length : | 29-766 |
Purity : | >90 % |
Stability : | One year at -70 centigrade from date of shipment. |
Storage : | Store product at –70 centigrade. For optimal storage, aliquot targets into smaller quantities after centrifugation and store at the recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Concentration : | 0.2 μg/μL |
Storage Buffer : | Recombinant protein stored in 50mM sodium phosphate, pH 7.5, 300mM NaCl, 150mM imidazole. |
Shipping : | On dry ice. |
Gene Name : | DPP4 dipeptidyl peptidase 4 [ Homo sapiens (human) ] |
Official Symbol : | DPP4 |
Synonyms : | DPP4; dipeptidyl peptidase 4; CD26; ADABP; ADCP2; DPPIV; TP103; dipeptidyl peptidase 4; ADCP-2; DPP IV; Gly-Pro naphthylamidase; Post-proline dipeptidyl aminopeptidase IV; T-cell activation antigen CD26; Xaa-Pro-dipeptidylaminopeptidase; adenosine deaminase complexing protein 2; dipeptidyl peptidase IV; dipeptidylpeptidase 4; dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); EC 3.4.14.5 |
Gene ID : | 1803 |
mRNA Refseq : | NM_001935 |
Protein Refseq : | NP_001926 |
MIM : | 102720 |
UniProt ID : | P27487 |
Products Types
◆ Recombinant Protein | ||
DPP4-7872H | Recombinant Human DPP4 protein(Ser484~Val728), His-tagged | +Inquiry |
DPP4-040H | Recombinant Human DPP4 Protein, His-tagged | +Inquiry |
Dpp4-2641M | Recombinant Mouse Dpp4 Protein, Myc/DDK-tagged | +Inquiry |
DPP4-2845H | Recombinant Human DPP4 Protein, GST-tagged | +Inquiry |
DPP4-675H | Recombinant Human DPP4 protein(29-766aa), His-tagged | +Inquiry |
◆ Native Protein | ||
DPP4-31H | Active Native Human Dipeptidyl Peptidase-IV | +Inquiry |
DPP4-197H | Native Human Dipeptidyl Peptidase IV | +Inquiry |
◆ Lysates | ||
DPP4-733CCL | Recombinant Cynomolgus DPP4 cell lysate | +Inquiry |
DPP4-2979HCL | Recombinant Human DPP4 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0313 | DPP IV Immunocapture Activity Assay Kit | +Inquiry |
Kit-0317 | DPPIV/CD26 Assay Kit | +Inquiry |
Kit-0314 | DPP4 Activity Fluorometric Assay Kit | +Inquiry |
Kit-0312 | Dipeptidyl peptidase IV Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewIts purity and efficacy make it an ideal choice for precise and accurate analysis, allowing me to generate reliable results.
By incorporating the DPP4 Protein into their studies, scientists can confidently conduct their research, ushering in groundbreaking discoveries and novel insights within their respective domains.
Its exceptional purity and functionality make it an ideal choice for accurate and precise analysis, ensuring reliable and reproducible results.
Q&As (5)
Ask a questionDPP4 plays a crucial role in glucose homeostasis by cleaving incretin hormones. In diabetes, inhibiting DPP4 can enhance the action of these hormones, promoting insulin release and lowering blood sugar levels.
Common side effects of DPP4 inhibitors include respiratory and urinary tract infections, headache, and nasopharyngitis. However, they are generally well-tolerated.
Inhibitors of DPP4 are used in the treatment of type 2 diabetes to improve glycemic control. They work by prolonging the activity of incretin hormones, such as GLP-1, which stimulate insulin secretion.
DPP4 inhibitors are often used as monotherapy or in combination with other antidiabetic medications to achieve optimal glycemic control.
DPP4 inhibitors work by enhancing the effects of incretin hormones, while other diabetes medications may act on insulin sensitivity, insulin release, or glucose absorption.
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