Active Recombinant Human ERBB2 Protein, Fc Chimera
Cat.No. : | ERBB2-552H |
Product Overview : | Recombinant Human ERBB2 (Accession # NP_004439), fused with , was produced in Mouse myeloma cell line, NS0-derived. |
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Species : | Human |
Source : | Mammalian Cells |
Tag : | Fc |
Predicted N Terminal : | Thr23 |
Form : | Lyophilized from a 0.2 µm filtered solution in PBS. |
Bio-activity : | Measured by its ability to block anti-ErbB2 mediated inhibition of SK-BR-3 human breast cancer cell proliferation. Brodowicz, T. et al. (1997) Int. J. Cancer 73:875.The ED50 for this effect is typically 20-80 ng/mL in the presence of 0.6 µg/mL goat anti-hErbB2. |
Molecular Mass : | Recombinant Human ERBB2, Fc Chimera has a calculated MW of 96.8 kDa (monomer). In SDS-PAGE migrates as 125-130 kDa, reducing conditions220-250 kDa, non-reducing conditions. |
Purity : | >90%, by SDS-PAGE with silver staining. |
Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC). |
Gene Name | ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) [ Homo sapiens ] |
Official Symbol | ERBB2 |
Synonyms | ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); NGL, v erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); receptor tyrosine-protein kinase erbB-2; CD340; HER 2; HER2; NEU; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 19 protein; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastoma derived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); NGL; TKR1; HER-2; MLN 19; HER-2/neu; |
Gene ID | 2064 |
mRNA Refseq | NM_001005862 |
Protein Refseq | NP_001005862 |
MIM | 164870 |
UniProt ID | P04626 |
Chromosome Location | 17q11.2-q12 |
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Not For Human Consumption!
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