Active Recombinant Human FASTK, GST-tagged

• Cat.No.: FASTK-1402H
• Product Overview: Recombinant full-length human FASTK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: Full length
• Description: FASTK or Fas-Activated Serine/Threonine Kinase is a member of the serine/threonine protein kinase family that becomes rapidly activated during Fas-mediated apoptosis in Jurkat cells and in response to Fas receptor ligation. FASTK interacts with and phosphorylates TIA1 which is an apoptosis-promoting nuclear RNA-binding protein. FAST K influences alternative pre-mRNA splicing by affecting the activity of TIA-1/TIAR. FASTK is a strong inducer of lymphocyte apoptosis. FASTK is the component of the molecular cascade that involved in FAS-mediated apoptosis. FASTK is highly expreesed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas.
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 1.0 nmol/min/mg
• Molecular Mass: ~84 kDa
• Purity: >70%
• Applications: Kinase Assay, Western Blot
• Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: FASTK Fas-activated serine/threonine kinase [ Homo sapiens ]
• Official Symbol: FASTK
• Synonyms: FASTK; Fas-activated serine/threonine kinase; fas-activated serine/threonine kinase; FAST; FAST kinase
• Gene ID: 10922
• mRNA Refseq: NM_006712
• Protein Refseq: NP_006703
• MIM: 606965
• UniProt ID: Q14296
• Chromosome Location: 7q35
• Function: ATP binding; Fas-activated serine/threonine kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity