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Active Recombinant Human FLT3 Protein, GST-tagged

Cat.No. : FLT3-4370H
Product Overview : Human PDK3 (NP_004110.2, 546 a.a. - 993 a.a.) partial recombinant protein with GST tag expressed in Baculovirus infected Sf21 cells.
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Description : This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq
Source : Insect Cell
Species : Human
Tag : GST
Form : Liquid
Bio-activity : The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorescence-labeled substrate and Mg (or Mn)/ATP. The phosphorylated and unphosphorylated substrates were separated and detected by LabChip™3000.
Substrate: Srctide.
ATP: 100 μM.
Molecular Mass : 77 kDa
Purity : 98% by SDS-PAGE/CBB staining
Applications : Functional Study
SDS-PAGE
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.05% Brij35, 1 mM DTT, 10% glycerol)
Protein length : 546-993
Gene Name : FLT3 fms-related tyrosine kinase 3 [ Homo sapiens ]
Official Symbol : FLT3
Synonyms : FLT3; fms-related tyrosine kinase 3; receptor-type tyrosine-protein kinase FLT3; CD135; FLK2; STK1; STK-1; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; fms-like tyrosine kinase 3; stem cell tyrosine kinase 1; growth factor receptor tyrosine kinase type III; FLK-2;
Gene ID : 2322
mRNA Refseq : NM_004119
Protein Refseq : NP_004110
MIM : 136351
UniProt ID : P36888

Not For Human Consumption!

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Reviews
08/01/2021

    Excellent product, great price.

    12/22/2020

      Satisfied, will order again.

      09/14/2020

        Quick response, helpful service.

        Q&As (7)

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        How is FLT3 implicated in acute myeloid leukemia (AML)? 12/24/2021

        FLT3 is frequently mutated in AML, contributing to uncontrolled cell growth and poor prognosis.

        In which cells or tissues is FLT3 predominantly expressed? 07/08/2021

        FLT3 is predominantly expressed in hematopoietic stem cells and progenitor cells.

        How does FLT3 contribute to hematopoiesis? 03/15/2021

        It is essential for hematopoiesis, particularly in the proliferation of early progenitor cells.

        Are there therapeutic strategies targeting FLT3 for disease treatment? 08/01/2020

        Therapeutic strategies include FLT3 inhibitors, showing effectiveness in treating AML patients with FLT3 mutations.

        What is the primary biological function of FLT3 in cells? 06/27/2020

        FLT3 is a receptor tyrosine kinase that plays a crucial role in cell survival, proliferation, and differentiation.

        What role does FLT3 play in the proliferation and differentiation of hematopoietic stem cells? 07/14/2019

        It stimulates the proliferation and differentiation of hematopoietic stem cells, guiding their development into various blood cell types.

        What are the common mutations found in FLT3 associated with diseases? 04/05/2019

        Common mutations include internal tandem duplications (ITD) and tyrosine kinase domain (TKD) mutations, leading to constitutive activation of FLT3.

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