Active Recombinant Human GDF3 Protein

• Cat.No.: GDF3-048H
• Product Overview: The mature recombinant human GDF-3 protein (251-364aa) without tag was expressed in E. coli.

Specification

• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein plays a role ocular and skeletal development. Mutations in this gene are associated with microphthalmia, coloboma, and skeletal abnormalities in human patients.
• Source: E. coli
• Species: Human
• Bio-activity: Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 100-150 ng/mL.
• Molecular Mass: 12.9 kDa
• Product-Related Proteins: 251-364
• Endotoxin: < 0.1 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: GDF3 growth differentiation factor 3 [ Homo sapiens (human) ]
• Official Symbol: GDF3
• Synonyms: GDF3; growth differentiation factor 3; KFS3; MCOP7; MCOPCB6; growth/differentiation factor 3
• Gene ID: 9573
• mRNA Refseq: NM_020634
• Protein Refseq: NP_065685
• MIM: 606522
• UniProt ID: Q9NR23