Active Recombinant Human GHR Homodimer Protein, His&Avi tagged

• Cat.No.: GHR-42H
• Product Overview: GHR protein dimer contains a GHR extracellular domain (UniProt# P10912) fused with a proprietary dimer motif followed by a tandem His-Avi tag at the C-terminus was expressed in HEK293T.

Specification

• Species: Human
• Source: HEK293T
• Tag: Avi&His
• Protein Length: 19-264 aa
• Description: Human growth hormone receptor (GHR) is the transmembrane protein receptor for growth hormone and a member of the Type I cytokine receptor family of receptors. GHR is also known as GH binding protein (GHBP) and GHIP. GHR contains an extracellular domain with two fibronectin type III β domains followed by a single-pass transmembrane domain and a cytoplasmic intracellular domain. GHR can form dimers as preformed dimer and growth hormone induced dimer. GHR dimerization is crucial for growth hormone signaling to activate an intracellular enzyme Janus kinase 2 (JAK2). GHR is widely distributed in the body, and the preformed GHR homodimer is expressed across a wide range of cellular types in different tissues. Mutations in the GHR gene have been associated with growth hormone insensitivity syndrome (GHIS) and growth hormone plays a significant role in cancer development. A recombinant protein mimicking the GHR dimer conformation can be crucial for therapeutic innovation.
• Molecular Mass: 76 kDa
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for GHR-specific antibodies and ELISA and SPR for growth hormone ligand protein binding assays. Suggested Applications: SPR and BLI for GHR-specific antibodies and BLI for growth hormone protein binding assays. Animal immunization, RUO.
• Storage: Store at -80 centigrade.
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name: GHR growth hormone receptor [ Homo sapiens (human) ]
• Official Symbol: GHR
• Synonyms: GHR; growth hormone receptor; GH receptor; serum binding protein; somatotropin receptor; growth hormone binding protein; GHBP
• Gene ID: 2690
• mRNA Refseq: NM_000163
• Protein Refseq: NP_000154
• MIM: 600946
• UniProt ID: P10912