Active Recombinant Human HAVCR1 protein, Fc-tagged
Cat.No. : | HAVCR1-227H |
Product Overview : | Recombinant Human HAVCR1(Ser21-Thr288) fused with Fc region of Human IgG1 at C-terminal was expressed in HEK293. |
- Specification
- Gene Information
- Related Products
Description : | T cell immunoglobulin and mucin domain 1 (TIM-1), also known as KIM-1 and HAVcr1, is a member of the TIM family which is involved in the regulation of innate and adaptive immune responses. TIM-1 is a type I transmembrane protein that contains an N-terminal immunoglobulin-like domain, a mucin domain with O- and N-linked carbohydrates, a transmembrane segment, and a cytoplasmic signaling domain. Multiple TIM-1 variants can be produced due to polymorphisms or alternative splicing resulting in deletions in the mucin domain. Within the extracellular domain, human TIM-1 shares 41% aa sequence identity with mouse and rat TIM-1. TIM-1 is expressed on splenic B cells, IL-10+ regulatory B cells, CD4+ T cells, mast cells, invariant NKT (iNKT) cells, dendritic cells, kidney epithelium and a broad range of mucosal epithelium. It is upregulated on activated Th2 cells, after dendritic cell maturation, and on kidney tubular epithelial cells after injury. Metalloproteinase-mediated cleavage of TIM-1 at the membrane-proximal region results in the release of a soluble form of TIM-1 which is detectable in the urine and in circulation. TIM-1 serves as a receptor for phosphatidylserine, LMIR5/CD300b, TIM-1 (homophilic), TIM-4, IgA, and the glycoproteins of a number of enveloped viruses. Its interaction with phosphatidylserine enables TIM-1 to mediate the phagocytosis of apoptotic cells and iNKT cell activation. TIM-1 binding induces the activation of LMIR5-expressing myeloid cells, contributing to tissue homeostasis as well as damage following kidney injury. TIM-1 ligation co-stimulates T cell activation and enhances Th2 cytokine production. In humans, TIM-1 serves as a cellular entry receptor for various viruses, including hepatitis A virus, Ebolavirus and Marburgvirus. |
Source : | HEK293 |
Species : | Human |
Tag : | Fc |
Predicted N Terminal : | Ser21 |
Form : | Lyophilized from a 0.2 μm filtered solution in PBS. |
Bio-activity : | Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells. The ED50 for this effect is typically 0.6-3.6 μg/mL. |
Molecular Mass : | Predicted Molecular Mass: 55 kDa SDS-PAGE: 112-129 kDa, reducing conditions |
Endotoxin : | <0.1 EU per 1 μg of the protein by the LAL method. |
Purity : | >85%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | Reconstitute at 500 μg/mL in PBS. |
Gene Name : | HAVCR1 hepatitis A virus cellular receptor 1 [ Homo sapiens ] |
Official Symbol : | HAVCR1 |
Synonyms : | HAVCR1; hepatitis A virus cellular receptor 1; HAVCR; HAVCR 1; TIM 1; TIM1; TIMD1; kidney injury molecule 1; T-cell membrane protein 1; T cell immunoglobin domain and mucin domain protein 1; TIM; KIM1; KIM-1; TIM-1; TIMD-1; HAVCR-1; |
Gene ID : | 26762 |
mRNA Refseq : | NM_001099414 |
Protein Refseq : | NP_001092884 |
MIM : | 606518 |
UniProt ID : | Q96D42 |
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Havcr1-2298M | Recombinant Mouse Havcr1 protein(Tyr22-Thr212), His&hFc-tagged | +Inquiry |
◆ Lysates | ||
HAVCR1-2486CCL | Recombinant Canine HAVCR1 cell lysate | +Inquiry |
HAVCR1-2141HCL | Recombinant Human HAVCR1 cell lysate | +Inquiry |
HAVCR1-2003CCL | Recombinant Cynomolgus HAVCR1 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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