Active Recombinant Human IL12, HIgG1 Fc-tagged

Cat.No. : IL12-001H
Product Overview : The human IL-12 complex composed of the p40 subunit (NP_002178.2) (ILe23-Ser328) and the p35 subunit (NP_000873.2)(Arg57-Ser253) is fused through a polypeptide linker to the Fc region of mouse IgG2a was expressed in CHO cell.
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  • Gene Information
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Source : CHO cell
Species : Human
Tag : HIgG1 Fc-tagged
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured in a cell proliferation assay.
Molecular Mass : 85KDa(monomer)
AA Sequence : The human IL-12 complex composed of the p40 subunit (NP_002178.2) (ILe23-Ser328) and the p35 subunit (NP_000873.2)(Arg57-Ser253) is fused through a polypeptide linker to the Fc region of mouse IgG2a.
Endotoxin : <0.06 eu/μg as determined by lal>
Purity : ≥98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : IL-12
Official Symbol : IL12
Synonyms : IL12; IL12B; IL-12B
Gene ID : 100860847
mRNA Refseq : NM_001285700
Protein Refseq : NP_001272629
UniProt ID : P68221
Pathway : African trypanosomiasis, organism-specific biosystem;Allograft rejection, organism-specific biosystem;Chagas disease (American trypanosomiasis), organism-specific biosystem

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Q&As (10)

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How does fluorescence microscopy track IL12 internalization and intracellular trafficking? 11/21/2022

Fluorescence microscopy tracks IL12 internalization and trafficking.

What techniques dissect IL12's signaling cascades and crosstalk with other cytokines? 11/13/2022

Phosphoproteomics and flow cytometry dissect IL12's signaling and crosstalk.

What strategies assess IL12's polarization of T cell subsets and cytokine profiles? 01/30/2022

Flow cytometry and ELISA assess IL12's T cell subset polarization and cytokine profiles.

How are reporter gene assays tailored to study IL12's promoter activity and response elements? 01/27/2022

Reporter gene assays analyze IL12's promoter activity and response elements.

What insights into IL12's cellular distribution and dynamics do super-resolution imaging methods provide? 09/02/2021

Super-resolution imaging details IL12's cellular distribution and dynamics.

What are the benefits of using 3D cell culture models to investigate IL12's effects on tissue microenvironments? 03/31/2021

3D cell culture models reveal IL12's effects on tissue microenvironments.

How do protein-protein interaction assays decipher IL12's binding partners in cellular context? 02/22/2021

Co-localization studies and co-IP assays identify IL12's binding partners.

What methods elucidate IL12's receptor complex formation and stoichiometry? 12/18/2020

Techniques like co-immunoprecipitation reveal IL12 receptor complex assembly.

Can you elaborate on the utility of ChIP-seq in understanding IL12-regulated gene expression networks? 10/10/2020

ChIP-seq helps map IL12-induced gene expression patterns and regulatory regions.

Could you explain how transgenic models help dissect IL12's roles in immune response modulation? 03/19/2020

Transgenic models elucidate IL12's roles in immune response regulation.

Customer Reviews (3)

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    Effective in Th1 cell differentiation. -


      High specificity in ELISA. -


        Stable under storage. -

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