Active Recombinant Human IL1A
Cat.No. : | IL1A-337H |
Product Overview : | Human IL1A (P01583, 113 a.a.-271 a.a.) partial recombinant protein expressed in Escherichia coli. |
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Cat. No. : | IL1A-337H |
Description : | Interleukin-1 alpha (IL-1μ) is a protein that in humans is encoded by the IL1A gene. The protein encoded by this gene is a cytokine of the interleukin-1 family. Interleukin-1 alpha possesses a wide spectrum of metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor. |
Sequence : | SAPFSFLS NVKYNFMRII KYEFILNDAL NQSIIRANDQ YLTAAALHNL DEAVKFDMGA YKSSKDDAKI TVILRISKTQ LYVTAQDEDQ PVLLKEMPEI PKTITGSETN LLFFWETHGT KNYFTSVAHP NLFIATKQDY WVCLAGGPPS ITDFQILENQ A |
Theoretical MW (kDa) : | 18 |
Form : | Lyophilized |
Preparation Method : | Escherichia coli expression system |
Purity : | > 97% by SDS-PAGE and HPLC |
Endotoxin Level : | < 0.1 ng/ug (1 EU/ug) |
Activity : | The ED50 was determined by the dose-dependent stimulation of murine D10S cells is μ 0.002 ng/mL, corresponding to a specific activity of μ 2 x 109 units/mg |
Application : | SDS-PAGE |
Storage Buffer : | Lyophilized from PBS, pH 7.0 |
Storage : | Store at -20°C on dry atmosphere for 2 years. After reconstitution with deionized water, store at 4°C for 1 month or store at -20°C for 6 months. Aliquot to avoid repeated freezing and thawing. |
Unitprot ID : | P01583 |
Pathways : | Apoptosis; Cytokine-cytokine receptor interaction; Graft-versus-host disease; Hematopoietic cell lineage; MAPK signaling pathway; Prion diseases; Type I diabetes mellitus |
Tag : | Non |
Gene Name : | IL1A interleukin 1, alpha [ Homo sapiens ] |
Official Symbol : | IL1A |
Synonyms : | IL1A; interleukin 1, alpha; IL1; IL-1A; IL1F1; IL1-ALPHA; preinterleukin 1 alpha; hematopoietin-1; pro-interleukin-1-alpha; Interleukin-1 alpha; IL-1 alpha; Hematopoietin-1; IL1A (IL1F1) |
Gene ID : | 3552 |
mRNA Refseq : | NM_000573 |
Protein Refseq : | NP_000566 |
MIM : | 147760 |
Chromosome Location : | 2q14 |
Function : | cytokine activity; interleukin-1 receptor binding; protein binding |
Products Types
◆ Lysates | ||
IL1A-2911HCL | Recombinant Human IL1A cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewHigh solubility.
Good for intracellular staining.
Effective in apoptosis assays.
Q&As (10)
Ask a questionCross-talk between IL-1α's and other cytokines is dissected through methods such as co-immunoprecipitation, ELISA, and cytokine profiling arrays.
IL-1α's paradoxical roles are dissected using conditional knockout mice, 3D culture systems, and molecular analyses to delineate context-specific effects.
Single-cell RNA sequencing uncovers heterogeneity in IL-1α-responsive cell populations and their roles, revealing distinct molecular profiles and functions.
IL-1α's intricate pro-inflammatory signaling pathways are decoded using advanced techniques like mass spectrometry, phosphoproteomics, and bioinformatics.
Genetic editing tools like CRISPR-Cas9 unveil IL-1α's contributions to diseases by generating knockout models and studying resulting phenotypic changes.
In vitro co-culture systems are manipulated to study IL-1α-mediated responses, elucidating immune-stromal cell interactions via cytokine-specific neutralization.
Specific cellular receptors and effectors influenced by IL-1α are identified through techniques like co-immunoprecipitation, ChIP-seq, and siRNA knockdown.
Live-cell microscopy captures real-time IL-1α release dynamics and its impact on neighboring cells, facilitated by fluorescent tagging and high-resolution imaging.
Longitudinal studies and statistical modeling establish the quantitative relationship between IL-1α levels and disease progression, offering predictive insights.
Multi-omics analyses provide a holistic view of IL-1α signaling's impact, integrating transcriptomics, proteomics, and metabolomics data for comprehensive insights.
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