Active Recombinant Human IL1A

• Cat.No.: IL1A-337H
• Product Overview: Human IL1A (P01583, 113 a.a.-271 a.a.) partial recombinant protein expressed in Escherichia coli.

Specification

• Species: Human
• Source: Human
• Tag: Non
• Description: Interleukin-1 alpha (IL-1μ) is a protein that in humans is encoded by the IL1A gene. The protein encoded by this gene is a cytokine of the interleukin-1 family. Interleukin-1 alpha possesses a wide spectrum of metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor.
• Sequence: SAPFSFLS NVKYNFMRII KYEFILNDAL NQSIIRANDQ YLTAAALHNL DEAVKFDMGA YKSSKDDAKI TVILRISKTQ LYVTAQDEDQ PVLLKEMPEI PKTITGSETN LLFFWETHGT KNYFTSVAHP NLFIATKQDY WVCLAGGPPS ITDFQILENQ A
• Theoretical MW (kDa): 18
• Form: Lyophilized
• Preparation Method: Escherichia coli expression system
• Purity: > 97% by SDS-PAGE and HPLC
• Endotoxin Level: < 0.1 ng/ug (1 EU/ug)
• Activity: The ED50 was determined by the dose-dependent stimulation of murine D10S cells is μ 0.002 ng/mL, corresponding to a specific activity of μ 2 x 109 units/mg
• Application: SDS-PAGE
• Storage Buffer: Lyophilized from PBS, pH 7.0
• Storage: Store at -20°C on dry atmosphere for 2 years. After reconstitution with deionized water, store at 4°C for 1 month or store at -20°C for 6 months. Aliquot to avoid repeated freezing and thawing.
• Unitprot ID: P01583
• Pathways: Apoptosis; Cytokine-cytokine receptor interaction; Graft-versus-host disease; Hematopoietic cell lineage; MAPK signaling pathway; Prion diseases; Type I diabetes mellitus

Gene Information

• Gene Name: IL1A interleukin 1, alpha [ Homo sapiens ]
• Official Symbol: IL1A
• Synonyms: IL1A; interleukin 1, alpha; IL1; IL-1A; IL1F1; IL1-ALPHA; preinterleukin 1 alpha; hematopoietin-1; pro-interleukin-1-alpha; Interleukin-1 alpha; IL-1 alpha; Hematopoietin-1; IL1A (IL1F1)
• Gene ID: 3552
• mRNA Refseq: NM_000573
• Protein Refseq: NP_000566
• MIM: 147760
• Chromosome Location: 2q14
• Function: cytokine activity; interleukin-1 receptor binding; protein binding