Il1a Protein

Il1a

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Il1a

Official Full Name interleukin 1, alpha
Background The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.
Synonyms BAF; FAF; Hematopoietin 1; Hematopoietin-1; IL 1 alpha; IL 1; IL 1A; IL-1 alpha; Il-1a; IL1 ALPHA; IL1; IL1A; IL1A_HUMAN; IL1F1; ilia; Interleukin 1 alpha precursor; Interleukin-1 alpha; Interleukin1 alpha; LAF; LEM; Preinterleukin 1 alpha; Pro interleukin 1 alpha; Prointerleukin 1 alpha; IL1-ALPHA
    • Species :
    • Canine
    • Caprine
    • Caprine (Goat)
    • Cattle
    • Cotton Rat
    • Dog
    • Equine
    • Guinea pig
    • Horse
    • Human
    • Mouse
    • Pig
    • Porcine
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Source :
    • CHO
    • CHO-K1
    • E. coli
    • E.coli
    • HEK293
    • Human
    • Human Cell
    • Insect cells
    • Mammalian Cell
    • Yeast
    • Tag :
    • Avi
    • Fc
    • GST
    • His
    • His(C-ter)
    • S
    • SUMO
    • T7
    • MBP&His-Avi
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL1A-131H Active Recombinant Human IL1A protein E.coli N/A Inquiry
    Human Il1A-26382H Active Recombinant Human Il1A, HIgG1 Fc-tagged, mutant CHO Fc Inquiry
    Human Il1A-26682H Active Recombinant Human Il1A, HIgG1 Fc-tagged CHO Fc Inquiry
    Human IL1A-337H Active Recombinant Human IL1A Human N/A Inquiry
    Human IL1A-36682H Active Recombinant Human IL1A, MIgG2a Fc-tagged CHO Fc Inquiry
    Human IL1A-501H Active Recombinant human IL1A HEK293 N/A Inquiry
    Cotton Rat Il1a-380C Active Recombinant Cotton Rat Il1a E.coli N/A Inquiry
    Human IL1A-01HG Active GMP Recombinant Human IL1A Protein CHO-K1 Inquiry
    Mouse IL1a-01M Active Recombinant Mouse IL1a Protein, His-Tagged E.coli His Inquiry
    Porcine IL1A-01P Active GMP Recombinant Porcine IL1A Protein, His-Tagged E.coli His Inquiry
    Human IL1A-101HG Active GMP Recombinant Human IL1A protein E.coli N/A Inquiry
    Human IL1A-102HG Active GMP Recombinant Human IL1A Protein HEK293 N/A Inquiry
    Human IL1A-01H Recombinant Human IL1A protein E.coli N/A Inquiry
    Human IL1A-109H Recombinant Human Interleukin 1, Alpha, Fc Chimera HEK293 Fc Inquiry
    Human IL1A-134H Recombinant Human Interleukin 1, Alpha, His-tagged E.coli His Inquiry
    Human IL1A-14166H Recombinant Human IL1A, GST-tagged E.coli GST Inquiry
    Human IL1A-625H Recombinant Human IL1A protein, His & T7-tagged E.coli His/T7 Inquiry
    Mouse Il1a-03M Recombinant Mouse Interleukin-1 Alpha E.coli N/A Inquiry
    Mouse Il1a-306M Recombinant Mouse Il1a, None tagged E.coli N/A Inquiry
    Mouse Il1a-545M Recombinant Mouse Il1a protein E.coli N/A Inquiry
    Mouse Il1a-627M Recombinant Mouse Il1a protein, His & T7-tagged E.coli His/T7 Inquiry
    Mouse IL1a-640M Recombinant Mouse interleukin 1, alpha, His-tagged E.coli His Inquiry
    Mouse IL1A-8134M Recombinant Mouse IL1A Protein Mammalian Cell His Inquiry
    Mouse IL1a-92M Recombinant Mouse IL-1 alpha Yeast N/A Inquiry
    Rat IL1A-3032R Recombinant Rat IL1A Protein Mammalian Cell His Inquiry
    Rat Il1a-573R Recombinant Rat Il1a protein E.coli N/A Inquiry
    Rat Il1a-630R Recombinant Rat Il1a protein, His & T7-tagged E.coli His/T7 Inquiry
    Rat Il1a-75R Recombinant Rat Il1a protein, His-tagged E.coli His Inquiry
    Rat Il1a-92R Recombinant Rat Interleukin 1 Alpha E.coli N/A Inquiry
    Rhesus Macaque IL1A-2238R Recombinant Rhesus monkey IL1A Protein, His-tagged Mammalian Cell His Inquiry
    Canine IL1a-46C Recombinant Canine IL-1 alpha Yeast N/A Inquiry
    Dog IL1A-620D Recombinant Dog IL1A protein, His-tagged E.coli His Inquiry
    Dog IL1A-621D Recombinant Dog IL1A protein, His & T7-tagged E.coli His/T7 Inquiry
    Rabbit IL1A-631R Recombinant Rabbit IL1A protein, His-tagged E.coli His Inquiry
    Equine IL1A-207E Recombinant Equine IL1A Yeast N/A Inquiry
    Pig IL1A-5432P Recombinant Pig Interleukin 1, Alpha E.coli N/A Inquiry
    Cattle IL1A-619C Recombinant Cattle IL1A protein, His-tagged E.coli His Inquiry
    Caprine (Goat) IL1A-622C Recombinant Caprine (Goat) IL1A protein, His-tagged E.coli His Inquiry
    Horse IL1A-623H Recombinant Horse IL1A protein, His-tagged E.coli His Inquiry
    Guinea pig Il1a-624G Recombinant Guinea pig Il1a protein, His & S-tagged E.coli His/S Inquiry
    Pig IL1A-629P Recombinant Pig IL1A protein, His-tagged E.coli His Inquiry
    Pig IL1α-81P Recombinant Porcine Interleukin-1 alpha E.coli N/A Inquiry
    Human IL1A-2911HCL Recombinant Human IL1A cell lysate Human Cell N/A Inquiry
    Mouse Il1a-044I Recombinant Mouse Il1a Protein (156 aa) E.coli Inquiry
    Human IL1A-05H Recombinant Human IL1A(Ser113-Ala271) Protein, C-Avi-tagged, Biotinylated E.coli Avi Inquiry
    Human IL1A-1017H Recombinant Human IL1A Protein, His-tagged E.coli N-His Inquiry
    Human IL1A-1018H Recombinant Human IL1A Protein, His-tagged E.coli N-His Inquiry
    Human IL1A-102I Recombinant Human IL1A Protein (159 aa) E.coli Inquiry
    Human IL1A-1399H Recombinant Human IL1A protein, MBP&His-Avi-tagged, Biotinylated E.coli MBP&His-Avi Inquiry
    Human IL1A-148H Recombinant Human IL1A Protein E.coli Inquiry
    Mouse IL1A-149M Recombinant Mouse IL1A Protein E.coli Inquiry
    Mouse Il1a-158M Recombinant Active Mouse IL1A Protein, His-tagged(C-ter) E.coli His(C-ter) Inquiry
    Human IL1A-159H Recombinant Active Human IL1A Protein, His-tagged(C-ter) E.coli His(C-ter) Inquiry
    Pig IL1A-160P Recombinant Active Pig IL1A Protein, His-tagged(C-ter) E.coli His(C-ter) Inquiry
    Rat Il1a-251I Recombinant Rat Il1a Protein CHO Inquiry
    Human IL1A-3095H Recombinant Human IL1A protein, His-tagged E.coli His Inquiry
    Human IL1A-5442H Recombinant Human IL1A protein, His-tagged Yeast His Inquiry
    Human IL1A-5443H Recombinant Human IL1A protein, His-tagged Yeast His Inquiry
    Rhesus macaque IL1A-5444R Recombinant Rhesus macaque IL1A protein, His-tagged Yeast His Inquiry
    Human IL1A-02H Recombinant Human IL1A Protein E. coli Inquiry
    Human IL1A-14167H Recombinant Human IL1A protein, GST-tagged E.coli GST Inquiry
    Human IL1A-2036H Recombinant Human IL1A Protein, His-tagged HEK293 His Inquiry
    Human IL1A-4315HG GMP Recombinant Human IL1A protein E.coli N/A Inquiry
    Human IL1A-85H Human Interleukin-1 alpha (rDNA derived) Reference standard N/A Inquiry
    Mouse Il1a-097M Recombinant Mouse Il1a Protein E.coli Inquiry
    Mouse Il1a-098M Recombinant Mouse Il1a Protein E.coli Inquiry
    Mouse Il1a-099M Recombinant Mouse Il1a Protein E.coli Inquiry
    Mouse Il1a-134M Mouse Interleukin-1 alpha (rDNA derived) Reference standard N/A Inquiry
    Mouse Il1a-7236M Recombinant Mouse Il1a Protein, His-tagged E.coli His Inquiry
    Rhesus Macaque IL1A-577R Recombinant Rhesus Macaque IL1A Protein (113-271 aa), His-SUMO-tagged E.coli His/SUMO Inquiry
    Rhesus IL1A-83R Recombinant Rhesus IL1A protein E.coli N/A Inquiry
    Dog IL1A-011D Recombinant Dog IL1A Protein, His-tagged Insect cells His Inquiry
    Caprine IL1A-4318C Recombinant Caprine IL1A Protein Yeast N/A Inquiry

    Il1a involved in several pathways and played different roles in them. We selected most pathways Il1a participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il1a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway CACNB3; MAP4K2; HSP70L; MAP2K1; PPM1A; LAMTOR3; CASP3A; PDGFA; PPM1AA; PLA2G4D
    Cytokine-cytokine receptor interaction Flt3l; CCL25; GM2002; IL23; CCL21B; IL1B; TGFB1A; LTB; TNFSF18; XCR1
    Apoptosis AKT1; MAP3K14; BCL2L11; ATM; HIST1H1B; HIST1H1C; ENDOG; TRP53; BIDA; IRF4A
    Osteoclast differentiation MAPK3; SIRPG; NCF2; PPP3R2; SIRPA; IL1A; TNF; PPP3CC; MAP2K7; PPP3CA
    Hematopoietic cell lineage CD1d1; CD1E, B2M; TNF; GP1BA; IL1R1; IL2RA; CD8A; CSF3; MME; CD3E
    Non-alcoholic fatty liver disease (NAFLD) NDUFS5; COX7A2; IL1A; NDUFA7; LEP; PRKAG3; NDUFA4L2; MAPK8; NDUFA10; NR1H3
    Type I diabetes mellitus PTPRN; IL1A; HLA-DRB4; HLA-DRB3; GAD1; H2-AA; IL1B; HLA-DQB1; TNF; CD28
    Prion diseases STIP1; C5; C9; LOC100033925; MAP2K1; C1QC; C1QB; PRNP; PRKACB; IL1A
    Salmonella infection ROCK2B; PKN1; KLC2; CDC42; FLNB; MAPK14B; MAPK13; IL6; WASF1; MAPK8A
    Pertussis MAPK9; TICAM2; C4BPB; CASP1; Il23a; Il12b; ITGA5; CXCL6; IL-8; Casp3; TRAF6
    Leishmaniasis HLA-DRB3; HLA-DRB5; HLA-DRA; FCGR2C; IL12A; Itgam&Itgb2; ELK1; TGFB1; ITGB2; FCGR1
    Tuberculosis TLR2; CD209C; H2-AB1; MAPK11; BAX; CLEC7A; IL12B; IFNA5; TNF; IL10RB
    Measles FAS; STAT5B; IRF3; CD3D; Il2; TLR9; IL6; IKBKE; NFKBIB; PIK3CA
    Influenza A NXF2; CASP9; RNASEL; DNAJB1; CPSF4; EIF2AK3; LOC780933; NLRP3; CYCS; BMA2
    Inflammatory bowel disease (IBD) IL21; IL23; HLA-DMB; Il4ra; TNF; HLA-DRA; HLA-DOA; IL4; Il2; HLA-DPA1
    Rheumatoid arthritis ATP6V0D2; CCL5; ATP6V1F; TLR2; ATP6V0E; ATP6V1D; TNFRSF11A; IL11; CD28; TGFB3
    Graft-versus-host disease IL1B; GZMB; H2-AB1; HLA-DOA; CD28; PRF1; FAS; HLA-DRB5; KLRD1; IL6

    Il1a has several biochemical functions, for example, copper ion binding, cytokine activity, interleukin-1 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il1a itself. We selected most functions Il1a had, and list some proteins which have the same functions with Il1a. You can find most of the proteins on our site.

    Function Related Protein
    copper ion binding COMMD1; PRND; LOXL3A; DBH; LOX; SNAI3; HEPHL1; ABHD1; ANG; LOXL5A
    cytokine activity INHBB; IL36B; NDR2; TGFB1A; INHBAA; INHBE; BMP6; WNT5A; FASLG; KITLG
    interleukin-1 receptor binding IL36RN; IL36G; Il1f6; IL1RAP; IRAK1; IL36A; IL1A; TRIP6; IL1F10; TLR9
    protein binding BDKRB1; SLC30A2; XPA; ARMCX5; PRRG2; ZNF259; FYCO1; BARHL2; RPGR; PAGE1

    Il1a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il1a here. Most of them are supplied by our site. Hope this information will be useful for your research of Il1a.

    CASP1; IL1R2; CASP1; SHARPIN; HAX1

    Caniattil, MCDL; Marchioro, AA; et al. Association of Cytokines in Individuals Sensitive and Insensitive to Dust Mites in a Brazilian Population. PLOS ONE 9:-(2014).
    Ramdasi, AY; Arya, RP; et al. Effect of Pregnancy on Anti-HEV Antibody Titres, Plasma Cytokines and the Corresponding Gene Expression Levels in the PBMCs of Patients Presenting with Self-Recovering Clinical and Subclinical Hepatitis E. PLOS ONE 9:-(2014).

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