Il1a

  • Official Full Name

    interleukin 1, alpha

  • Overview

    The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.
  • Synonyms

    BAF; FAF; Hematopoietin 1; Hematopoietin-1; IL 1 alpha; IL 1; IL 1A; IL-1 alpha; Il-1a; IL1 ALPHA; IL1; IL1A; IL1A_HUMAN; IL1F1; ilia; Interleukin 1 alpha precursor; Interleukin-1 alpha; Interleukin1 alpha; LAF; LEM; Preinterleukin 1 alpha; Pro interleukin 1 alpha; Prointerleukin 1 alpha; IL1-ALPHA;

  • Recombinant Proteins
  • GMP Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Caprine
  • Caprine (Goat)
  • Cattle
  • Cotton Rat
  • Cynomolgus monkey
  • Dog
  • Equine
  • Guinea pig
  • Horse
  • Human
  • Mouse
  • Pig
  • Porcine
  • Rabbit
  • Rat
  • Rhesus
  • Rhesus macaque
  • Rhesus Macaque
  • CHO
  • CHO-K1
  • E.coli
  • HEK293
  • Human
  • Human Cell
  • Insect cells
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • Avi
  • C
  • His
  • Myc
  • Fc
  • GST
  • His (Fc)
  • His(C
  • ter)
  • His|S
  • His|SUMO
  • His|T7
  • MBP
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL1A-501H Active Recombinant Human IL1A protein HEK293 N/A Ser113-Ala271
Human Il1A-26382H Active Recombinant Human Il1A, HIgG1 Fc-tagged, mutant CHO Fc
Human Il1A-26682H Active Recombinant Human Il1A, HIgG1 Fc-tagged CHO Fc
Human IL1A-36682H Active Recombinant Human IL1A, MIgG2a Fc-tagged CHO Fc
Human IL1A-131H Active Recombinant Human IL1A protein E.coli N/A
Human IL1A-337H Active Recombinant Human IL1A Human N/A
Human IL1A-1298H Acitve Recombinant Human IL1A protein(Ser113-Ala271) E.coli N/A Ser113-Ala271
Human IL1A-101HG Active GMP Recombinant Human IL1A protein E.coli N/A
Human IL1A-102HG Active GMP Recombinant Human IL1A Protein HEK293 N/A
Human IL1A-01HG Active GMP Recombinant Human IL1A Protein CHO-K1
Human IL1A-01H Recombinant Human IL1A protein E.coli N/A 159
Human IL1A-14166H Recombinant Human IL1A, GST-tagged E.coli GST 1-271a.a.
Human IL1A-109H Recombinant Human Interleukin 1, Alpha, Fc Chimera HEK293 Fc
Human IL1A-625H Recombinant Human IL1A protein, His & T7-tagged E.coli His/T7 Ser113~Ala271 (Accession # Q53QF9)
Human IL1A-134H Recombinant Human Interleukin 1, Alpha, His-tagged E.coli His
Human IL1A-2911HCL Recombinant Human IL1A cell lysate Human Cell N/A
Human IL1A-05H Recombinant Human IL1A(Ser113-Ala271) Protein, C-Avi-tagged, Biotinylated E.coli Avi
Human IL1A-85H Human Interleukin-1 alpha (rDNA derived) Reference standard N/A
Human IL1A-14167H Recombinant Human IL1A protein, GST-tagged E.coli GST 159
Human IL1A-2036H Recombinant Human IL1A protein, His-tagged HEK293 His Ser113-Ala271
Human IL1A-3095H Recombinant Human IL1A protein, His-tagged E.coli His 113-271aa
Human IL1A-1018H Recombinant Human IL1A Protein, His-tagged E.coli N-His Met1-Ala271
Human IL1A-1017H Recombinant Human IL1A Protein, His-tagged E.coli N-His Glu98-Ala271
Human IL1A-5443H Recombinant Human IL1A protein, His-tagged Yeast His 113-271aa
Human IL1A-5442H Recombinant Human IL1A protein, His-tagged Yeast His 113-271aa
Human IL1A-1399H Recombinant Human IL1A protein, MBP&His-Avi-tagged, Biotinylated E.coli MBP&His-Avi 113-271aa
Human IL1A-498H Recombinant Human IL1A Protein, Biotinylated 271
Human IL1A-4315HG GMP Recombinant Human IL1A protein E.coli N/A 159
Human IL1A-2631H Active Recombinant Human IL1A protein, His-tagged HEK293 His Ser113-Ala271
Human IL1A-159H Recombinant Active Human IL1A Protein, His-tagged(C-ter) E.coli His(C-ter)
Human IL1A-1577H Recombinant Human IL1A protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Ser113-Ala271
Human IL1A-2462H Recombinant Human IL1A Protein (Ser113-Ala271), C-His tagged E.coli C-His Ser113-Ala271
Human IL1A-162H Active Recombinant Human IL1A Protein (Ser113-Ala271), C-His tagged, Animal-free, Carrier-free E.coli C-His Ser113-Ala271
Human IL1A-148H Active Recombinant Human IL1A Protein E.coli
Human IL1A-2464H Recombinant Human IL1A Protein (Ser113-Ala271), C-His tagged Mammalian cells C-His Ser113-Ala271
Human IL1A-102I Active Recombinant Human IL1A Protein (159 aa) E.coli 159
Human IL1A-243H Active Recombinant Human IL1A Protein E.coli Tag Free
Human IL1A-02H Active Recombinant Human IL1A Protein E.coli 13-271
Mouse IL1a-01M Active Recombinant Mouse IL1a Protein, His-Tagged E.coli His
Mouse Il1a-627M Recombinant Mouse Il1a protein, His & T7-tagged E.coli His/T7 Ala116~Ser270 (Accession # P01582)
Mouse Il1a-306M Active Recombinant Mouse Il1a protein E.coli N/A Ser115-Ser270
Mouse Il1a-545M Recombinant Mouse Il1a protein E.coli N/A 156
Mouse IL1a-92M Recombinant Mouse IL-1 alpha Yeast N/A
Mouse IL1A-8134M Recombinant Mouse IL1A Protein Mammalian Cell His
Mouse IL1a-640M Recombinant Mouse interleukin 1, alpha, His-tagged E.coli His
Mouse Il1a-03M Recombinant Mouse Interleukin-1 Alpha E.coli N/A
Mouse IL1A-4502M Recombinant Mouse IL1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Il1a-044I Active Recombinant Mouse Il1a Protein (156 aa) E.coli 156
Mouse Il1a-098M Active Recombinant Mouse Il1a Protein E.coli
Mouse Il1a-134M Mouse Interleukin-1 alpha (rDNA derived) Reference standard N/A
Mouse IL1A-1576M Recombinant Mouse IL1A protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Ser115-Ser270
Mouse IL1A-4502M-B Recombinant Mouse IL1A Protein Pre-coupled Magnetic Beads HEK293
Mouse Il1a-099M Active Recombinant Mouse Il1a Protein E.coli
Mouse Il1a-6734M Recombinant Mouse Il1a Protein (Ser115-Ser270) E.coli Tag Free Ser115-Ser270
Mouse IL1A-1578M Recombinant Mouse IL1A protein, His-tagged HEK293 His Ser115-Ser270
Mouse Il1a-54M Active Recombinant Mouse Il1a Protein (Ser115-Ser270), C-His tagged, Animal-free, Carrier-free E.coli C-His Ser115-Ser270
Mouse Il1a-158M Recombinant Active Mouse IL1A Protein, His-tagged(C-ter) E.coli His(C-ter)
Mouse Il1a-097M Active Recombinant Mouse Il1a Protein E.coli
Mouse IL1A-149M Active Recombinant Mouse IL1A Protein E.coli
Mouse Il1a-7236M Recombinant Mouse Il1a Protein, His-tagged E.coli His 115-270
Rat Il1a-630R Recombinant Rat Il1a protein, His & T7-tagged E.coli His/T7 Ser115~Ser270 (Accession # P16598)
Rat Il1a-75R Recombinant Rat Il1a protein, His-tagged E.coli His
Rat Il1a-92R Recombinant Rat Interleukin 1 Alpha E.coli N/A
Rat IL1A-3032R Recombinant Rat IL1A Protein Mammalian Cell His
Rat Il1a-573R Recombinant Rat Il1a protein E.coli N/A 156
Rat IL1A-2687R Recombinant Rat IL1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Il1a-251I Active Recombinant Rat Il1a Protein CHO
Rat IL1A-2687R-B Recombinant Rat IL1A Protein Pre-coupled Magnetic Beads HEK293
Rabbit IL1A-631R Recombinant Rabbit IL1A protein, His-tagged E.coli His Gln132~Ser267 (Accession # P04822)
Dog IL1A-621D Recombinant Dog IL1A protein, His & T7-tagged E.coli His/T7 Glu94~Glu262 (Accession # O46612)
Dog IL1A-620D Recombinant Dog IL1A protein, His-tagged E.coli His Leu132~Pro265 (Accession # O46612)
Dog IL1A-011D Active Recombinant Dog IL1A Protein, His-tagged Insect cells His
Canine IL1a-46C Recombinant Canine IL-1 alpha Yeast N/A
Caprine IL1A-4318C Recombinant Caprine IL1A Protein Yeast N/A 156aa
Caprine (Goat) IL1A-622C Recombinant Caprine (Goat) IL1A protein, His-tagged E.coli His Gln90~Lys268 (Accession # P79161)
Cattle IL1A-619C Recombinant Cattle IL1A protein, His-tagged E.coli His Ile109~Val251
Cotton Rat Il1a-380C Active Recombinant Cotton Rat Il1a E.coli N/A
Cynomolgus monkey IL1A-3982C Recombinant Cynomolgus monkey IL1A protein(113-271aa), His-Myc-tagged Yeast C-His-Myc 113-271aa
Equine IL1A-207E Active Recombinant Equine IL1A Yeast N/A
Guinea pig Il1a-624G Recombinant Guinea pig Il1a protein, His & S-tagged E.coli His/S Ser111~Glu204 (Accession # Q60480)
Horse IL1A-623H Recombinant Horse IL1A protein, His-tagged E.coli His Asp95~Gln269 (Accession # Q28385)
Porcine IL1A-01P Active GMP Recombinant Porcine IL1A Protein, His-Tagged E.coli His
Rhesus IL1A-83R Recombinant Rhesus IL1A protein E.coli N/A 159
Rhesus Macaque IL1A-2238R Recombinant Rhesus monkey IL1A Protein, His-tagged Mammalian Cell His
Rhesus Macaque IL1A-577R Recombinant Rhesus Macaque IL1A Protein (113-271 aa), His-SUMO-tagged E.coli His/SUMO 113-271 aa
Rhesus macaque IL1A-5444R Recombinant Rhesus macaque IL1A protein, His-tagged Yeast His 113-271aa
Rhesus Macaque IL1A-2059R-B Recombinant Rhesus Macaque IL1A Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque IL1A-2059R Recombinant Rhesus Macaque IL1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Pig IL1A-5432P Recombinant Pig Interleukin 1, Alpha E.coli N/A
Pig IL1A-629P Recombinant Pig IL1A protein, His-tagged E.coli His Glu98~Leu266 (Accession # P18430)
Pig IL1α-81P Recombinant Porcine Interleukin-1 alpha E.coli N/A
Pig IL1A-160P Recombinant Active Pig IL1A Protein, His-tagged(C-ter) E.coli His(C-ter)
Pig IL1A-203P Active Recombinant Pig IL1A Protein (Ser113-Ser270), C-His tagged, Animal-free, Carrier-free E.coli C-His Ser113-Ser270
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

Il1a involved in several pathways and played different roles in them. We selected most pathways Il1a participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il1a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayTAB2;PPM1BB;MEF2CA;FGF6B;MAPK12A;HRASB;RPS6KA3A;FGF22;TGFB1
Cytokine-cytokine receptor interactionBMP2;VEGFB;CSF2RA;FAS;IFNA17;OSMR;IFNA8;PPBP;CCL17
ApoptosisNMT1;NFKB1;BIRC3;Fasl;IKBKG;TNFRSF10A;NFKBIA;RELA;JUN
Osteoclast differentiationLILRA1;CAMK4;NFKB1;LILRB5;IKBKB;RELB;STAT1;LILRB2;SPI1
Hematopoietic cell lineageGM-CSF;IL1B;FLT3LG;CD3G;IL11RA;CD37;CSF3R;CD1B;IL6R
Non-alcoholic fatty liver disease (NAFLD)NDUFA12;FAS;ITCH;LEP;NDUFB8;ERN1;MAPK10;BID;PRKAG3
Type I diabetes mellitusHLA-B;HLA-DQB1;CPE;PTPRN2;HLA-DQA1;IL12B;Fasl;FASLG;CD86
Prion diseasesELK1;FYN;C9;Hc;MAPK1;C8A;C1QB;C5;NCAM2
Salmonella infectionRHOGB;ARPC5B;DYNC1I2A;MAPK8;MYH10;CXCL8B.3;RILP;PKN3;MAPK3
PertussisGNAI1;IL23;MAPK9;IRAK4;CFL2;IL12A;IRF8;Hc;IL6
LeishmaniasisITGA4;IL12A;MAPK13;NOS2;IRAK4;IFNGR2;FCGR4;H2-AA;HLA-DPA1
TuberculosisITGAM;IRAK4;IFNA5;IFNA1;CD209B;TRAF6;EEA1;BAD;HLA-DMA
MeaslesIFNGR1;FASLG;CD209C;TLR9;IFNA12;HSPA8;CCNE1;CD28;CD3G
Influenza AAGFG1;NFKB1;PYCARD;CCL5;PRKCA;OAS3;OAS1A;DNAJB1;PIK3R3
Inflammatory bowel disease (IBD)TGFB2;HLA-DPA1;Il4ra;HLA-DOA;HLA-DOB;IL6;IL1A;RELA;TBX21
Rheumatoid arthritisCCL3L3;CXCL1;TGFB3;ATP6V1B1;IFNG;ITGB2L;ATP6V1C1;H2-AA;Il23a; Il12b
Graft-versus-host diseaseKIR3DL1;PRF1;IL1B;HLA-DRB1;KIR2DL3;HLA-DMB;HLA-DRA;HLA-DQA2;HLA-A

Il1a has several biochemical functions, for example, copper ion binding, cytokine activity, interleukin-1 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il1a itself. We selected most functions Il1a had, and list some proteins which have the same functions with Il1a. You can find most of the proteins on our site.

Function Related Protein
copper ion bindingAOC3;S100U;LOXL5A;TYR;COX11;LOXL4;P2RX4;SCO1;LOX
cytokine activityCCL38A.5;LTA;FAM3D;BMP7;GDF10;IFNA5;Ifnl2;Ccl27a;GPI1
interleukin-1 receptor bindingIL1RN;IL36B;Il1f6;TLR9;IL36RN;TRIP6;IRAK1;IL1F10;IL36G
protein bindingSIPA1L2;VSIG4;IRF9;KRTAP8-1;OSTC;NAP1L1;FLT1;RPL28;IRF2BP1

Il1a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il1a here. Most of them are supplied by our site. Hope this information will be useful for your research of Il1a.

CASP1; IL1R2; CASP1; SHARPIN; HAX1

Gene Family

IL

Research Area

Related articles

Caniattil, MCDL; Marchioro, AA; et al. Association of Cytokines in Individuals Sensitive and Insensitive to Dust Mites in a Brazilian Population. PLOS ONE 9:-(2014).
Ramdasi, AY; Arya, RP; et al. Effect of Pregnancy on Anti-HEV Antibody Titres, Plasma Cytokines and the Corresponding Gene Expression Levels in the PBMCs of Patients Presenting with Self-Recovering Clinical and Subclinical Hepatitis E. PLOS ONE 9:-(2014).
  • Reviews
  • Q&As

Customer Reviews (3)

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Reviews
04/08/2021

    High solubility.

    07/02/2020

      Good for intracellular staining.

      03/13/2019

        Effective in apoptosis assays.

        Q&As (10)

        Ask a question
        What methods are employed to dissect the intricate cross-talk between IL-1α and other cytokines, shedding light on its role in immune modulation? 11/02/2021

        Cross-talk between IL-1α's and other cytokines is dissected through methods such as co-immunoprecipitation, ELISA, and cytokine profiling arrays.

        What experimental approaches allow researchers to dissect the paradoxical roles of IL-1α as both a pro-inflammatory and tissue repair mediator in distinct contexts? 09/22/2021

        IL-1α's paradoxical roles are dissected using conditional knockout mice, 3D culture systems, and molecular analyses to delineate context-specific effects.

        How are cutting-edge techniques like single-cell RNA sequencing utilized to unravel the heterogeneity in IL-1α-responsive cell populations and their functional implications? 06/07/2021

        Single-cell RNA sequencing uncovers heterogeneity in IL-1α-responsive cell populations and their roles, revealing distinct molecular profiles and functions.

        How is the intricate web of IL-1α's pro-inflammatory signaling pathways decoded using advanced experimental techniques? 05/26/2021

        IL-1α's intricate pro-inflammatory signaling pathways are decoded using advanced techniques like mass spectrometry, phosphoproteomics, and bioinformatics.

        How are state-of-the-art genetic editing tools such as CRISPR-Cas9 applied to unravel IL-1α's precise contributions to inflammatory diseases? 04/06/2021

        Genetic editing tools like CRISPR-Cas9 unveil IL-1α's contributions to diseases by generating knockout models and studying resulting phenotypic changes.

        How do researchers manipulate in vitro co-culture systems to dissect the dynamic interplay between immune cells and stromal cells in IL-1α-mediated responses? 06/18/2020

        In vitro co-culture systems are manipulated to study IL-1α-mediated responses, elucidating immune-stromal cell interactions via cytokine-specific neutralization.

        What experimental strategies enable the identification of specific cellular receptors and downstream effectors responsible for IL-1α's diverse physiological effects? 03/19/2020

        Specific cellular receptors and effectors influenced by IL-1α are identified through techniques like co-immunoprecipitation, ChIP-seq, and siRNA knockdown.

        How are sophisticated imaging techniques like live-cell microscopy harnessed to capture the real-time dynamics of IL-1α release and its impact on neighboring cells? 12/02/2019

        Live-cell microscopy captures real-time IL-1α release dynamics and its impact on neighboring cells, facilitated by fluorescent tagging and high-resolution imaging.

        How is the quantitative relationship between IL-1α levels and disease progression established through longitudinal studies and statistical modeling? 07/15/2018

        Longitudinal studies and statistical modeling establish the quantitative relationship between IL-1α levels and disease progression, offering predictive insights.

        How do multi-omics analyses, including transcriptomics and proteomics, provide a holistic view of the network of molecules influenced by IL-1α signaling? 06/04/2018

        Multi-omics analyses provide a holistic view of IL-1α signaling's impact, integrating transcriptomics, proteomics, and metabolomics data for comprehensive insights.

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