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Official Full Name interleukin 1, alpha
Background The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease.
Synonyms BAF; FAF; Hematopoietin 1; Hematopoietin-1; IL 1 alpha; IL 1; IL 1A; IL-1 alpha; Il-1a; IL1 ALPHA; IL1; IL1A; IL1A_HUMAN; IL1F1; ilia; Interleukin 1 alpha precursor; Interleukin-1 alpha; Interleukin1 alpha; LAF; LEM; Preinterleukin 1 alpha; Pro interleukin 1 alpha; Prointerleukin 1 alpha; IL1-ALPHA
    • Species :
    • Canine
    • Caprine
    • Caprine (Goat)
    • Cattle
    • Cotton Rat
    • Dog
    • Equine
    • Guinea pig
    • Horse
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Source :
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • Human
    • Human Cell
    • Insect cells
    • Mammalian Cell
    • Yeast
    • Tag :
    • Avi
    • Fc
    • GST
    • His
    • S
    • SUMO
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL1A-05H Recombinant Human IL1A(Ser113-Ala271) Protein, C-Avi-tagged, Biotinylated E.coli Avi
    Human IL1A-01H Recombinant Human IL1A protein E.coli N/A
    Human IL1A-02H Recombinant Human IL1A Protein E. coli
    Human IL1A-109H Recombinant Human Interleukin 1, Alpha, Fc Chimera HEK293 Fc
    Human IL1A-131H Recombinant Human IL1A protein E.coli N/A
    Human IL1A-134H Recombinant Human Interleukin 1, Alpha, His-tagged E.coli His
    Human IL1A-14166H Recombinant Human IL1A, GST-tagged E.coli GST
    Human IL1A-14167H Recombinant Human IL1A protein, GST-tagged E.coli GST
    Human IL1A-2036H Recombinant Human IL1A Protein, His-tagged HEK293 His
    Human Il1A-26382H Recombinant Human Il1A, HIgG1 Fc-tagged, mutant CHO Fc
    Human Il1A-26682H Recombinant Human Il1A, HIgG1 Fc-tagged CHO Fc
    Human IL1A-2911HCL Recombinant Human IL1A cell lysate Human Cell N/A
    Human IL1A-337H Recombinant Human IL1A Human N/A
    Human IL1A-36682H Recombinant Human IL1A, MIgG2a Fc-tagged CHO Fc
    Human IL1A-4315HG GMP Recombinant Human IL1A protein E.coli N/A
    Human IL1A-501H Recombinant human IL1A HEK293 N/A
    Human IL1A-625H Recombinant Human IL1A protein, His & T7-tagged E.coli His/T7
    Human IL1A-85H Human Interleukin-1 alpha (rDNA derived) Reference standard N/A
    Mouse Il1a-03M Recombinant Mouse Interleukin-1 Alpha E.coli N/A
    Mouse Il1a-097M Recombinant Mouse Il1a Protein E.coli
    Mouse Il1a-098M Recombinant Mouse Il1a Protein E.coli
    Mouse Il1a-099M Recombinant Mouse Il1a Protein E.coli
    Mouse Il1a-134M Mouse Interleukin-1 alpha (rDNA derived) Reference standard N/A
    Mouse Il1a-306M Recombinant Mouse Il1a, None tagged E.coli N/A
    Mouse Il1a-545M Recombinant Mouse Il1a protein E.coli N/A
    Mouse Il1a-627M Recombinant Mouse Il1a protein, His & T7-tagged E.coli His/T7
    Mouse IL1a-640M Recombinant Mouse interleukin 1, alpha, His-tagged E.coli His
    Mouse Il1a-7236M Recombinant Mouse Il1a Protein, His-tagged E.coli His
    Mouse IL1A-8134M Recombinant Mouse IL1A Protein Mammalian Cell His
    Mouse IL1a-92M Recombinant Mouse IL-1 alpha Yeast N/A
    Rat IL1A-3032R Recombinant Rat IL1A Protein Mammalian Cell His
    Rat Il1a-573R Recombinant Rat Il1a protein E.coli N/A
    Rat Il1a-630R Recombinant Rat Il1a protein, His & T7-tagged E.coli His/T7
    Rat Il1a-75R Recombinant Rat Il1a protein, His-tagged E.coli His
    Rat Il1a-92R Recombinant Rat Interleukin 1 Alpha E.coli N/A
    Rhesus Macaque IL1A-2238R Recombinant Rhesus monkey IL1A Protein, His-tagged Mammalian Cell His
    Rhesus Macaque IL1A-577R Recombinant Rhesus Macaque IL1A Protein (113-271 aa), His-SUMO-tagged E.coli His/SUMO
    Rhesus IL1A-83R Recombinant Rhesus IL1A protein E.coli N/A
    Dog IL1A-011D Recombinant Dog IL1A Protein, His-tagged Insect cells His
    Canine IL1a-46C Recombinant Canine IL-1 alpha Yeast N/A
    Dog IL1A-620D Recombinant Dog IL1A protein, His-tagged E.coli His
    Dog IL1A-621D Recombinant Dog IL1A protein, His & T7-tagged E.coli His/T7
    Rabbit IL1A-631R Recombinant Rabbit IL1A protein, His-tagged E.coli His
    Equine IL1A-207E Recombinant Equine IL1A Yeast N/A
    Cotton Rat Il1a-380C Recombinant Cotton Rat Il1a E.coli N/A
    Caprine IL1A-4318C Recombinant Caprine IL1A Protein Yeast N/A
    Pig IL1A-5432P Recombinant Pig Interleukin 1, Alpha E.coli N/A
    Cattle IL1A-619C Recombinant Cattle IL1A protein, His-tagged E.coli His
    Caprine (Goat) IL1A-622C Recombinant Caprine (Goat) IL1A protein, His-tagged E.coli His
    Horse IL1A-623H Recombinant Horse IL1A protein, His-tagged E.coli His
    Guinea pig Il1a-624G Recombinant Guinea pig Il1a protein, His & S-tagged E.coli His/S
    Pig IL1A-629P Recombinant Pig IL1A protein, His-tagged E.coli His
    Pig IL1α-81P Recombinant Porcine Interleukin-1 alpha E.coli N/A

    Il1a involved in several pathways and played different roles in them. We selected most pathways Il1a participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il1a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway PDGFB; HSC70; FGF6A; FGF2; PPP3R1B; C11orf52; PPM1AA; CACNG6A; FGF14; HSP70L
    Cytokine-cytokine receptor interaction IL5; CXCL11; CXCR3.1; IL11; PDGFRA; Flt3l; BMPR2B; IL6ST; IL22RA2; IL21
    Osteoclast differentiation FCGR3A; FYN; IL1A; MAPK8; IFNB1; LILRA4; MAP2K1; MAPK9; PIK3R1; AKT2
    Hematopoietic cell lineage FCER2; Itga10&Itgb1; CD4; IL9R; IL6R; IL1R1; CD37; CD3G; IL3; CD19
    Non-alcoholic fatty liver disease (NAFLD) COX6B2; ERN1; Il6ra; PRKAG2; PIK3CB; NDUFC2-KCTD14; UQCRH; COX7B2; PIK3CG; UQCRFS1
    Type I diabetes mellitus INS; PTPRN; HSPD1; FAS; IL1A; ICA1; GZMB; H2-Q10; CD80; CD86
    Prion diseases PRNP; STIP1; LAMC1; LOC100033925; MAP2K1; C7; PRKACG; MAPK3; C1QC; ELK1
    Salmonella infection ACTG1; MAPK8; NOS2A; CASPA; ACTB1; CDC42L2; TLR4BB; PFN3; PYCARD; CCL4L1
    Pertussis C4BP; NOS2; IRAK1; C3; CALM3; RELA; IL12A; Itgam&Itgb2; C4BPA; GNAI1
    Leishmaniasis HLA-DQB1; NCF2; MAPK11; ITGA4; STAT1; TAB2; TLR4; TLR2; NFKBIB; CYBA
    Tuberculosis PMAP-36; ATP6V0A4; CLEC4E; TGFB3; NFYA; EEA1; LAMP2; FCGR4; IFNA4; AKT1
    Influenza A Ifna15; NFKB1; IFNB1; EP300; BCL2L2-PABPN1; MAPK11; IL-8; STAT1; PABPN1L; CXCL8
    Inflammatory bowel disease (IBD) STAT4; H2-AB1; HLA-DMB; IFNGR2; TNF; IL12RB1; IL18; TBX21; HLA-DMA; RORA
    Rheumatoid arthritis ITGB2; H2-AB1; CD80; HLA-DPB1; ATP6V0B; ATP6V1A; TNFSF11; ATP6V1C1; ATP6V0E1; IFNG
    Graft-versus-host disease KIR3DL2; HLA-DRB4; KIR2DL3; HLA-DPA1; HLA-E; PRF1; GZMB; HLA-G; HLA-F; IL6

    Il1a has several biochemical functions, for example, copper ion binding, cytokine activity, interleukin-1 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il1a itself. We selected most functions Il1a had, and list some proteins which have the same functions with Il1a. You can find most of the proteins on our site.

    Function Related Protein
    copper ion binding F5; LOXL4; S100A13; ATP7B; HEPHL1; ANG; SERPINB1A; LOXL3B; SLC11A2; IL1A
    cytokine activity IL17C; IL18; IFNK; TNFSF15; INHBC; INHBAB; GDF9; IFNT2; IL19; IL1B
    interleukin-1 receptor binding IL36B; IRAK4; IL36A; IL1RN; IL1B; IL37; IL1RAP; TLR5; TLR9; Il1f6
    protein binding NCL; FAM114A1; LMO1; H3F3C; DOK3; NCAM1A; SIRPG; DERL2; ARPIN; LCK

    Il1a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il1a here. Most of them are supplied by our site. Hope this information will be useful for your research of Il1a.


    Caniattil, MCDL; Marchioro, AA; et al. Association of Cytokines in Individuals Sensitive and Insensitive to Dust Mites in a Brazilian Population. PLOS ONE 9:-(2014).
    Ramdasi, AY; Arya, RP; et al. Effect of Pregnancy on Anti-HEV Antibody Titres, Plasma Cytokines and the Corresponding Gene Expression Levels in the PBMCs of Patients Presenting with Self-Recovering Clinical and Subclinical Hepatitis E. PLOS ONE 9:-(2014).


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