Il1a
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Official Full Name
interleukin 1, alpha
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Background
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. -
Synonyms
BAF; FAF; Hematopoietin 1; Hematopoietin-1; IL 1 alpha; IL 1; IL 1A; IL-1 alpha; Il-1a; IL1 ALPHA; IL1; IL1A; IL1A_HUMAN; IL1F1; ilia; Interleukin 1 alpha precursor; Interleukin-1 alpha; Interleukin1 alpha; LAF; LEM; Preinterleukin 1 alpha; Pro interleukin 1 alpha; Prointerleukin 1 alpha; IL1-ALPHA;
- Involved Pathway
- Protein Function
- Interacting Protein
- Il1a Related Articles
- Il1a Related Gene Family
- Il1a Related Research Area
Il1a involved in several pathways and played different roles in them. We selected most pathways Il1a participated on our site, such as MAPK signaling pathway, Cytokine-cytokine receptor interaction, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il1a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | NLK;CACNB3;ACVR1C;MAP3K2;MAPT;GRB2A;Fasl;CACNB3A;MAP3K6 |
| Cytokine-cytokine receptor interaction | IFNA1;CCL3L3;CCL20A.3;FIGF;VEGFA;CXCL10;CXCR6;CCL13;IL21 |
| Apoptosis | IKBKG;NFKBIA;BNIP3L;CASP12;RNF8;Fasl;HIST1H1E;CASP9;BAXA |
| Osteoclast differentiation | LILRA4;NFKBIA;MAPK8;FCGR1;SOCS1;LILRA5;MAPK1;LILRB3;FHL2 |
| Hematopoietic cell lineage | CD36;HLA-DRB5;IL6;HLA-DRB4;TNF;CR2;IL6R;CD8B;MME |
| Non-alcoholic fatty liver disease (NAFLD) | NDUFB1;NDUFB2;NDUFB8;IKBKB;NDUFV3;NDUFA13;NDUFA1;BID;COX7B |
| Type I diabetes mellitus | H2-AA;HLA-C;IL12B;HLA-DMB;CPE;CD80;HLA-DOA;HLA-DRB3;HLA-G |
| Prion diseases | C1QB;C1QA;CASP12;PRKACG;C8A;STIP1;CCL5;LOC100033925;IL6 |
| Salmonella infection | ACTB;TLR5B;KLC4;ARPC5L;MAPK14B;FLNC;RHOGD;TLR4BA;KLC1 |
| Pertussis | TLR4;MAPK1;CALM1;TICAM2;MAPK11;CASP1;LY96;MAPK8;MAPK3 |
| Leishmaniasis | PTGS2;TGFB2;NFKB1;ITGB2L;NCF2;HLA-DOB;IRAK1;HLA-DQB1;IL1A |
| Tuberculosis | IFNA21;FCGR1;RAB5C;CAMP;CEBPG;SYK;PLK3;NFKB1;RIPK2 |
| Measles | MSN;AKT1;PIK3CB;IFNAR1;CCNE1;OAS1;IFNA12;HSPA2;PIK3R5 |
| Influenza A | HNRNPUL1;IRF7;IL12A;BLB2;CPSF4;MAPK13;TNFRSF1A;CASP9;IL8L2 |
| Inflammatory bowel disease (IBD) | IL5;IL18;TGFB3;IFNGR1;HLA-DMA;H2-AB1;IL12A;IL2RG;STAT6 |
| Rheumatoid arthritis | ATP6V0D1;CTLA4;CCL20;IL-8;H2-AB1;TNFSF13;HLA-DQA1;ANGPT1;ATP6V1B1 |
| Graft-versus-host disease | HLA-DRB1;IL6;FAS;IL1B;TNF;H2-AB1;HLA-G;Il2;KLRD1 |
Il1a has several biochemical functions, for example, copper ion binding, cytokine activity, interleukin-1 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Il1a itself. We selected most functions Il1a had, and list some proteins which have the same functions with Il1a. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| copper ion binding | S100A12;LOXL3;SERPINB1A;ATP7A;HAMP;LOXL2;POLR1B;COX17;AOC2 |
| cytokine activity | NAMPT;CSF1A;Il1f8;BMP1;Ccl12;IL20;GDF10B;CLCF1;MIF |
| interleukin-1 receptor binding | IL36RN;IL36A;IL36B;IRAK4;IL1RAP;IL1F10;IL37;Il1f6;IL1RN |
| protein binding | ST6GAL1;CIRBP;PAK1IP1;HIST3H3;TFIP11;HIST1H4A;DCLRE1B;PPM1F;YES1 |
Il1a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il1a here. Most of them are supplied by our site. Hope this information will be useful for your research of Il1a.
CASP1; IL1R2; CASP1; SHARPIN; HAX1
- Q&As
- Reviews
Q&As (10)
Ask a questionCross-talk between IL-1α's and other cytokines is dissected through methods such as co-immunoprecipitation, ELISA, and cytokine profiling arrays.
IL-1α's paradoxical roles are dissected using conditional knockout mice, 3D culture systems, and molecular analyses to delineate context-specific effects.
Single-cell RNA sequencing uncovers heterogeneity in IL-1α-responsive cell populations and their roles, revealing distinct molecular profiles and functions.
IL-1α's intricate pro-inflammatory signaling pathways are decoded using advanced techniques like mass spectrometry, phosphoproteomics, and bioinformatics.
Genetic editing tools like CRISPR-Cas9 unveil IL-1α's contributions to diseases by generating knockout models and studying resulting phenotypic changes.
In vitro co-culture systems are manipulated to study IL-1α-mediated responses, elucidating immune-stromal cell interactions via cytokine-specific neutralization.
Specific cellular receptors and effectors influenced by IL-1α are identified through techniques like co-immunoprecipitation, ChIP-seq, and siRNA knockdown.
Live-cell microscopy captures real-time IL-1α release dynamics and its impact on neighboring cells, facilitated by fluorescent tagging and high-resolution imaging.
Longitudinal studies and statistical modeling establish the quantitative relationship between IL-1α levels and disease progression, offering predictive insights.
Multi-omics analyses provide a holistic view of IL-1α signaling's impact, integrating transcriptomics, proteomics, and metabolomics data for comprehensive insights.
Customer Reviews (3)
Write a reviewHigh solubility. -
Good for intracellular staining. -
Effective in apoptosis assays. -
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