Active Recombinant Human IL1B, MIgG2a Fc-tagged
| Cat.No. : | IL1B-465H |
| Product Overview : | The extracellular domain of human IL-1b (NP_000567.1)(Ala117-Ser269) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell. |
- Specification
- Gene Information
- Related Products
| Description : | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced byactivated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1(CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety ofcellular activities, including cell proliferation, differentiation, and apoptosis. The induction ofcyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute toinflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine genecluster on chromosome 2. |
| Source : | CHO cell |
| Species : | Human |
| Tag : | MIgG2a Fc-tagged |
| Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
| Bio-activity : | cytokine activity; interleukin-1 receptor binding; protein binding |
| Molecular Mass : | 43KDa (monomer) |
| AA Sequence : | Ala117-Ser269 |
| Endotoxin : | <0.06 eu/μg as determined by lal> |
| Purity : | >98%, by SDS-PAGE under reducing conditions. |
| Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
| Warning : | Avoid freeze/thaw cycles. |
| Gene Name : | IL1B interleukin 1, beta [ Homo sapiens ] |
| Official Symbol : | IL1B |
| Synonyms : | IL1B; interleukin 1, beta; interleukin-1 beta; IL 1B; IL1 BETA; IL1F2; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; IL-1; IL1-BETA; |
| Gene ID : | 3553 |
| mRNA Refseq : | NM_000576 |
| Protein Refseq : | NP_000567 |
| MIM : | 147720 |
| UniProt ID : | P01584 |
| Chromosome Location : | 2q14 |
| Pathway : | African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Apoptosis, organism-specific biosystem; |
| Function : | cytokine activity; cytokine activity; growth factor activity; interleukin-1 receptor binding; protein domain specific binding; |
Products Types
| ◆ Recombinant Protein | ||
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| Il1b-161M | Recombinant Active Mouse IL1B Protein, His-tagged(C-ter) | +Inquiry |
| Il1b-363I | Active Recombinant Rat Il1b Protein (152 aa) | +Inquiry |
| IL1B-163H | Active Recombinant Human IL1B Protein (Ala117-Ser269), C-His tagged, Animal-free, Carrier-free | +Inquiry |
| Il1b-180I | Active Recombinant Rat Il1b Protein | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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