Active Recombinant Human Il23A, HIgG1 Fc-tagged Il23A-003H

Active Recombinant Human Il23A, HIgG1 Fc-tagged

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Active Recombinant Human Il23A, HIgG1 Fc-tagged

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Cat.No. : Il23A-003H Optional Service: Optional requirements on this protein
Product Overview : The human IL-23 complex composed of the IL23a subunit(NP_057668.1) (Met1-Pro189) and the IL12b subunit(NP_002178.2)(Ile23-Ser328) is fused through a polypeptide linker to the Fc region of human IgG1was expressed in CHO cell.
Description : This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this proteinand the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12(IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4,and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) Tcells, IL23 preferentially acts on memory CD4(+) T cells
Source : CHO cell
Species : Human
Tag : HIgG1 Fc-tagged
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured by its binding ability in a functional ELISA.
Molecular Mass : 81KDa (monomer)
AA Sequence : The human IL-23 complex composed of the IL23a subunit(NP_057668.1) (Met1-Pro189) and the IL12b subunit(NP_002178.2)(Ile23-Ser328) is fused through a polypeptide linker to the Fc region of human IgG1.
Endotoxin : <0.06 eu/μg as determined by lal>
Purity : >98%, by SDS-PAGE under reducing conditions
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : IL23A interleukin 23, alpha subunit p19 [ Homo sapiens ]
Official Symbol : IL23A
Synonyms : IL23A; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; IL 23; IL 23A; IL23P19; interleukin six; G CSF related factor; P19; SGRF; IL-23-A; IL-23p19; IL-23 subunit alpha; interleukin 23 p19 subunit; interleukin-23 subunit p19; JKA3 induced upon T-cell activation; interleukin-six, G-CSF related factor; IL-23; IL-23A; MGC79388;
Gene ID : 51561
mRNA Refseq : NM_016584
Protein Refseq : NP_057668
MIM : 605580
UniProt ID : Q9NPF7
Chromosome Location : 12q13.13
Pathway : ATF-2 transcription factor network, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; IL23-mediated signaling events, organism-specific biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem; Pertussis, organism-specific biosystem;
Function : cytokine activity; contributes_to interleukin-23 receptor binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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