Active Recombinant Human KDM6A protein, FLAG-tagged

• Cat.No.: KDM6A-84H
• Product Overview: Recombinant Human KDM6A (a.a: 1-1401) fussed with FLAG tag at N-terminal was expressed in Insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Flag
• Protein Length: 1-1401 a.a.
• Description: This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene.
• Form: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween20, 20% glycerol, 80 μg/ml FLAG peptide.
• Bio-activity: 0.6 pmol/min/μg
• Molecular Mass: 155 kDa
• Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Stability: At least 6 months at –80 centigrade. Storing diluted enzyme is not recommended, if necessary, use carrier protein (BSA 0.1 – 0.5%). Avoid freeze/thaw cycles.

Gene Information

• Gene Name: KDM6A lysine (K)-specific demethylase 6A [ Homo sapiens ]
• Official Symbol: KDM6A
• Synonyms: UTX; KABUK2; bA386N14.2; lysine-specific demethylase 6A; bA386N14.2 (ubiquitously transcribed X chromosome tetratricopeptide repeat protein (UTX)); histone demethylase UTX; ubiquitously transcribed tetratricopeptide repeat protein X-linked; ubiquitously-transcribed TPR gene on the X chromosome
• Gene ID: 7403
• mRNA Refseq: NM_021140
• Protein Refseq: NP_066963
• MIM: 300128
• UniProt ID: O15550
• Chromosome Location: Xp11.2
• Pathway: Chromatin modifying enzymes, organism-specific biosystem; Chromatin organization, organism-specific biosystem; HDMs demethylate histones, organism-specific biosystem
• Function: RNA polymerase II core promoter proximal region sequence-specific DNA binding; dioxygenase activity; histone demethylase activity (H3-K27 specific)