Active Recombinant Human KDR, Fc-tagged, Biotinylated
Cat.No. : | KDR-631H |
Product Overview : | The recombinant human KDR/VEGFR2/CD309 extracellular or ecto-domain (ECD) Fc-fusion protein is expressed as a 756 amino acid protein consisting of Ala20 - Glu764 region of KDR and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions. |
- Specification
- Gene Information
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Source : | Human cells |
Species : | Human |
Tag : | Fc |
Form : | Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule). |
Bio-activity : | Binds VEGF and inhibits VEGF-dependent proliferation of human umbilical vein endothelial cells (HUVEC). |
Molecular Mass : | Calculated molecular mass (kDa): 108.9; Estimated by SDS-PAGE under reducing condition (kDa): 130-140. |
AA Sequence : | ASVGLPSVSLDLPRLSIQKDILTIK ANTTLQITCRGQRDLDWLWPNNQSG SEQRVEVTECSDGLFCKTLTIPKVI GNDTGAYKCFYRETDLASVIYVYVQ DYRSPFIASVSDQHGVVYITENKNK TVVIPCLGSISNLNVSLCARYPEK RFVPDGNRISWDSKKGFTIPSYMIS YAGMVFCEAKINDESYQSIMYIVVV VGYRIYDVVLSPSHGIELSVGEKL VLNCTARTELNVGIDFNWEYPSSKH QHKKLVNRDLKTQSGSEMKKFLSTL TIDGITRSDQGLYTCAASSGLMTK KNSTFVRVHEKPFVAFGSGMESLVE ATVGERVRIPAKYLGYPPPEIKWYK NGIPLESNHTIKAGHVLTIMEVSE RDTGNYTVILTNPISKEKQSHVVSL VVYVPPQIGEKSLISPVDSYQYGTT QTLTCTVYAIPPPHHIHWYWQLEE ECANEPSHAVSVTNPYPCEEWRSVE DFQGGNKIEVNKNQFALIEGKNKTV STLVIQAANVSALYKCEAVNKVGR GERVISFHVTRGPEITLQPDMQPTE QESVSLWCTADRSTFENLTWYKLGP QPLPIHVGELPTPVCKNLDTLWKL NATMFSNSTNDILIMELKNASLQDQ GDYVCLAQDRKTKKRHCVVRQLTVL ERVAPTITGNLENQTTSIGESIEV SCTASGNPPPQIMWFKDNETLVEDS GIVLKDGNRNLTIRRVRKEDEGLYT CQACSVLGCAKVEAFFIIEGAQEK TNLESTGTHTCPPCPAPELLGGPSV FLFPPKPKDTLMISRTPEVTCVVVD VSHEDPEVKFNWYVDGVEVHNAKT KPREEQYNSTYRVVSVLTVLHQDWL NGKEYKCKVSNKALPAPIEKTISKA KGQPREPQVYTLPPSREEMTKNQV SLTCLVKGFYPSDIAVEWESNGQPE NNYKTTPPVLDSDGSFFLYSKLTVD KSRWQQGNVFSCSVMHEALHNHYT QKSLSLSPGK |
Endotoxin : | <0.1 eu per 1 μg of purified recombinant protein determined by the lal>0.1> |
Purity : | >95% judged by SDS-PAGE under reducing condition |
Storage : | The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles. |
Gene Name : | KDR kinase insert domain receptor (a type III receptor tyrosine kinase) [ Homo sapiens ] |
Official Symbol : | KDR |
Synonyms : | KDR; kinase insert domain receptor (a type III receptor tyrosine kinase); vascular endothelial growth factor receptor 2; CD309; FLK1; VEGFR; VEGFR2; soluble VEGFR2; fetal liver kinase 1; fetal liver kinase-1; protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factor receptor; |
Gene ID : | 3791 |
mRNA Refseq : | NM_002253 |
Protein Refseq : | NP_002244 |
MIM : | 191306 |
UniProt ID : | P35968 |
Chromosome Location : | 4q11-q12 |
Pathway : | Angiogenesis, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Focal Adhesion, organism-specific biosystem; Focal adhesion, organism-specific biosystem; |
Function : | ATP binding; Hsp90 protein binding; growth factor binding; integrin binding; nucleotide binding; protein binding; protein tyrosine kinase activity; receptor activity; receptor signaling protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor-activated receptor activity; |
Products Types
◆ Lysates | ||
KDR-1520MCL | Recombinant Mouse KDR cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1609 | KDR Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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