Active Recombinant Human LAMA3 & LAMB3 & LAMC2 protein

• Cat.No.: LAMA3/LAMB3/LAMC2-512H
• Product Overview: Recombinant Human LAMA3 & LAMB3 & LAMC2 was purified from 184A1 human mammary epithelial cell conditioned media. Filter Sterile, both processed and unprocessed forms are present.

Specification

• Description: Laminin 332 (formerly laminin 5) is a heterotrimeric basement membrane protein composed of the alpha3, beta3 and gamma2 chains of laminin. It is expressed in skin, breast and other tissues, where it is involved in formation of hemidesmosomes and wound healing. Laminin 332 has been implicated in cancer progression. In breast cancer, laminin 332 has been identified as a microenvironmental protein which can act as a motility factor.
• Source: 184A1 human mammary epithelial cell conditioned media
• Species: Human
• Form: 150 mM NaCl, 10 mM Tris, pH 7.4
• Bio-activity: 10 ug/mL will induce scattering of 50% of MCF-7 cells after 24 hour incubation.
• Molecular Mass: 450 kDa, unprocessed
• Purity: Approximately 90%, Assessed by SDS PAGE.
• Storage: Storage Temperature: -20 centigrade or lower (Thawed protein retains activity for 1 month if stored at 4 centigrade).

Gene Information

• Gene Name: LAMA3 laminin subunit alpha 3 [ Homo sapiens ]
• Official Symbol: LAMA3
• Synonyms: E170; LOCS; BM600; LAMNA; BM600 150kD subunit; LAM3, alpha-3 subunit; epiligrin 170 kda subunit; epiligrin alpha 3 subunit; kalinin 165kD subunit; kalinin subunit alpha; laminin 5, alpha-3 subunit; laminin A3; laminin, alpha 3 (nicein (150kD), kalinin (165kD), BM600 (150kD), epilegrin); laminin-5 alpha 3 chain; laminin-5 subunit alpha; laminin-6 subunit alpha; laminin-7 subunit alpha; nicein 150kD subunit; nicein subunit alpha
• Gene ID: 3909
• mRNA Refseq: NM_198129
• Protein Refseq: NP_937762
• UniProt ID: Q16787
• Chromosome Location: 18q11.2
• Pathway: Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Anchoring fibril formation, organism-specific biosystem; Cell-Cell communication, organism-specific biosystem
• Function: receptor binding; structural molecule activity