Active Recombinant Human Leucine Rich Repeat Transmembrane Neuronal 1, His-tagged

• Cat.No.: LRRTM1-5682H
• Product Overview: Recombinant Human LRRTM1protein was expressed in Murine myeloma cell line with a C-terminal 6-Histag. Ala35-Ile425.

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: His
• Protein Length: 35-425 a.a.
• Description: Human LRRTM1 is a58-59 kDa type I transmembrane protein that belongs to the LRRTM family ofproteins within the leucine-rich repeat superfamily. It is synthesized as aprecursor with a 34 amino acid signal sequence, a 393 aa luminal region, a 21aa transmembrane region, and a 74 aa cytoplasmic region. The luminal portionof LRRTM1 contains three N-linked glycosylation sites and 10 LRRs flanked bycysteine-rich domains. The cytoplasmic region contains several tyrosine,serine, and threonine residues that have potential to be phosphorylated andthus to be involved in signal transduction.
• Form: Lyophilized from a0.2 μm filtered solution in PBS.
• N-terminalSequence: Ala35
• Molecular Weight: 44.4 kDa
• Activity: Measuredby its ability to enhance neurite outgrowth of E18 rat embryonic corticalneurons. Able to significantly enhance neurite outgrowth when immobilized at6-25 μg/mL on a nitrocellulose-coated microplate.
• Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
• SDS-PAGE: 70-85kDa, reducing conditions.
• Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: 100μg/mL in sterile PBS
• Storage: Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months fromdate of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterileconditions after reconstitution. 3 months, -20 to -70°C under sterileconditions after reconstitution.

Gene Information

• Gene Name: LRRTM1 leucine rich repeattransmembrane neuronal 1 [ Homo sapiens ]
• Official Symbol: LRRTM1
• Synonyms: LRRTM1; leucine richrepeat transmembrane neuronal 1; FLJ32082; leucine-rich repeat transmembraneneuronal protein 1; leucine-rich repeat transmembrane neuronal 1 protein;UNQ675/PRO1309; OTTHUMP00000194829; OTTHUMP00000202801; OTTHUMP00000203404
• Gene ID: 347730
• mRNA Refseq: NM_178839
• Protein Refseq: NP_849161
• MIM: 610867
• UniProt ID: Q86UE6
• Chromosome Location: 2p12
• Function: molecular function