Active Recombinant Human NCR1 protein, Fc-tagged

• Cat.No.: NCR1-0526H
• Product Overview: Recombinant Human NCR1 protein(Gln22-Asn254), fused with Fc tag, was expressed in HEK293.

Specification

• Source: HEK293
• Species: Human
• Tag: Fc
• Form: Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 10 mM NaCl, pH7.5 with trehalose as protectant.
• Bio-activity: Immobilized Human NKp46, Fc Tag, premium grade at 1 μg/mL (100 μL/well) can bind Anti-NKP46 Antibody, Human IgG1 with a linear range of 0.2-4 ng/mL.
• Molecular Mass: This protein carries a human IgG1 Fc tag at the C-terminusThe protein has a calculated MW of 53.0 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Proteinlength: Gln22-Asn254
• Endotoxin: Less than 0.01 EU per μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
• Protein length: Gln22-Asn254

Gene Information

• Gene Name: NCR1 natural cytotoxicity triggering receptor 1 [ Homo sapiens ]
• Official Symbol: NCR1
• Synonyms: NCR1; natural cytotoxicity triggering receptor 1; LY94, lymphocyte antigen 94 (mouse) homolog (activating NK receptor; NK p46); CD335; NK p46; NKP46; NK cell-activating receptor; natural killer cell p46-related protein; lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46); LY94; NK-p46; FLJ99094
• Gene ID: 9437
• mRNA Refseq: NM_001145457
• Protein Refseq: NP_001138929
• MIM: 604530
• UniProt ID: O76036

Reviews

09/28/2022

In drug screening experiments, it was found that it had good selectivity for specific disease-related targets.

03/28/2022

It has been observed in cell culture experiment that it can promote the growth and proliferation of cells.

03/04/2021

It has a wide range of applications and can be used in various biological experiments.

Q&As

What is the significance of the expression level of NCR1 protein in cancer immunotherapy?

In some cancer immunotherapies, the expression level of NCR1 protein may affect the efficacy of the treatment. High levels of NCR1 expression may predict a better prognosis.

What is the significance of gene knockout technology to inhibit NCR1 expression in the treatment of autoimmune diseases?

Inhibition of NCR1 expression by gene knockout technology can alleviate the symptoms of autoimmune diseases and provide new ideas and methods for the treatment of autoimmune diseases.

Is it possible to regulate the expression level of NCR1 protein through pharmacological intervention?

There are currently no drugs that directly target the NCR1 protein, but there are some drugs that can affect the activity of the immune system and thus indirectly affect the expression level of the NCR1 protein.

Are there polymorphisms in the NCR1 gene and are they involved in the development of certain diseases?

Yes, there are polymorphisms in the NCR1 gene, some of which may increase an individual's susceptibility to certain diseases such as inflammatory diseases and autoimmune diseases.

Are there antibodies or drugs against the NCR1 protein?

There are currently no specific antibodies or drugs against the NCR1 protein, but there are some studies that are exploring the development of therapies against the NCR1 protein.

How can the function and mechanism of NCR1 protein be studied?

The function and mechanism of action of NCR1 protein can be studied by gene knockout or knockdown techniques. In addition, techniques such as protein spectroscopy can be used to identify proteins that interact with NCR1 proteins and their sites of action.