Active Recombinant Human NGF protein
Cat.No. : | NGF-05H |
Product Overview : | Recombinant Human NGF protein(NP_002497.2)(Ser122-Arg239) was expressed in CHO. |
Availability | February 16, 2025 |
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Source : | CHO |
Species : | Human |
Tag : | Non |
Form : | Lyophilized from sterile 40mM His, 40mM Arg, 150mM NaCl, pH 5.5Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA. |
Bio-activity : | Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is typically 0.2-2 ng/ml. |
Molecular Mass : | The mature recombinant human β-NGF consists of 118 amino acids and has a predicted molecular mass of 13.2 kDa. β-NGF exists as a non-disulfide linked homodimer in solution. |
Protein length : | Ser122-Arg239 |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Purity : | > 95 % as determined by SDS-PAGE |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Publication : |
Development of novel HDL-mimicking α-tocopherol-coated nanoparticles to encapsulate nerve growth factor and evaluation of biodistribution. (2016)
Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor. (2015)
Preparation and Characterization of Novel HDL-mimicking Nanoparticles for Nerve Growth Factor Encapsulation (2017)
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Gene Name : | NGF nerve growth factor (beta polypeptide) [ Homo sapiens ] |
Official Symbol : | NGF |
Synonyms : | NGF; nerve growth factor (beta polypeptide); NGFB; beta-nerve growth factor; nerve growth factor, beta subunit; HSAN5; Beta-NGF; MGC161426; MGC161428; |
Gene ID : | 4803 |
mRNA Refseq : | NM_002506 |
Protein Refseq : | NP_002497 |
MIM : | 162030 |
UniProt ID : | P01138 |
Products Types
◆ Native Protein | ||
Ngf-182M | Active Native Mouse Ngf Protein | +Inquiry |
Ngf-298M | Active Native Mouse Nerve Growth Factor | +Inquiry |
Ngf-51M | Native Mouse Nerve Growth Factor 2.5S | +Inquiry |
◆ Lysates | ||
NGF-001MCL | Recombinant Mouse NGF cell lysate | +Inquiry |
NGF-001HCL | Recombinant Human NGF cell lysate | +Inquiry |
Related Gene
Not For Human Consumption!
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Customer Reviews (3)
Write a reviewHigh catalytic efficiency, high safety and high expression level of the protein make it perform well in many experiments.
The short half-life and high clearance of NGF make it possible to better control the concentration and action time of drugs in the body, so as to better control the therapeutic effect.
This production process of NGF pays attention to the recycling of resources and minimizes waste, which is very consistent with the principle of green production.
Q&As (6)
Ask a questionStudies have shown that NGF protein plays a role in the occurrence and development of pain. It stimulates the growth and survival of sensory neurons and enhances their ability to transmit signals, thereby increasing pain sensation. In addition, NGF can interact with other pain-related molecules to modulate pain perception and tolerance.
There are a variety of drug development treatments that target NGF proteins and their related signaling pathways, including direct administration of NGF proteins, use of their analogues, or drugs that inhibit its degradation. These treatments are in clinical trials and are expected to provide new options for the treatment of neurological disorders.
NGF proteins interact with target cells by binding to their receptors. It binds to TrkA receptors on the surface of target cells, triggering a series of signal transduction mechanisms that ultimately influence the biological behavior of target cells.
In addition to its important role in the nervous system, NGF proteins can also affect the function of other systems. For example, NGF proteins can affect the function of the immune system, involved in inflammatory responses and the development of autoimmune diseases.
The function of NGF protein in glial cells is mainly to regulate its proliferation, differentiation and apoptosis. In addition, NGF promotes the repair and regeneration of damaged neurons by glial cells.
NGF proteins have a variety of biological activities, including promoting neuronal growth, differentiation, survival, and repair of damage, regulating connections and signaling between neurons, and influencing the function of other systems.
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